CAS: 14261-75-7; Ethyl N-[1-(4-Chlorophenyl)-2-Methylpropan-2-Yl]Carbamate

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      专利号:US-8598153-B2
      优先权日:2006-09-22
      标题 :Method of treatment using fatty acid synthesis inhibitors
      发明人：SINGH SHEO B; TOTA MICHAEL R; WANG JUN
      权利人:SINGH SHEO B; TOTA MICHAEL R; WANG JUN; MERCK SHARP & DOHME
      摘要:The present invention relates to natural products that possess fatty acid synthesis inhibitor activity and can be used to treat and prevent diseases such as obesity, cancer, diabetes, fungal infections, Mycobacterium tuberculosis infections, malarial infections and other apicomplexan protozoal diseases.

      专利号:US-10968192-B2
      优先权日:2018-09-26
      标题:Crystalline solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide and methods of their synthesis
      发明人：BEDNARZ MARK STEPHEN; Dai Kuangchu; ECKERT JEFFREY MANNING; LIM NGIAP-KIE; SIROIS LAUREN; WU WENXUE; ZHAO MATTHEW MANGZHU
      权利人:LEXICON PHARMACEUTICALS INC
      摘要:Methods of preparing, and solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide, and salts, solvates and cocrystals thereof, are disclosed.

      专利号:US-2020255394-A1
      优先权日:2018-09-26
      标题 :Crystalline solid forms of n-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2h-pyran-2-yl)benzyl)phenyl)butanamide and methods of their synthesis

      专利号:WO-2020068661-A1
      优先权日:2018-09-26
      标题:Crystalline forms of n-(1 -((2-(dimethylamino)ethyl)amino)-2-m ethyl-1 -oopropan-2-yl)-4-(4-(2-methyl-5- (2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2h-pyran-2-yl)benzyl) phenl)butanamide and methods of their synthesis

      专利号:CA-3113037-A1
      优先权日:2018-09-26
      标 题 :Crystalline forms of n-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oopropan-2-yl)-4-(4-(2-methyl-5-(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2h-pyran-2-yl)benzyl)phenl)butanamide and methods of their synthesis

      专利号:AU-2007300627-A1
      优先权日:2006-09-22
      标题:Method of treatment using fatty acid synthesis inhibitors

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      主要参考文献


      1: Oberex (Draco) cloforex [Oberex (Draco) cloforex]. Lakartidningen. 1968 Mar 18;65:Suppl I:26. Swedish. 146(1):79-88. 28(5):391-405. doi: 10.1111/j.1600-0773.1970.tb00565.x. 12(4):360-6. doi: 10.1007/BF02894012. 33(4):317-20. doi: 10.1111/j.1600-0773.1973.tb01532.x. 7(3-4):569-83. doi: 10.1080/15287398109530002. 21(1):86-93. German.

      合成参考文献


      参考文献:10.1080/15376510701857262
      摘要:Kruhlak NL, Choi SS, Contrera JF, Weaver JL, Willard JM, Hastings KL, Sancilio LF. Development of a Phospholipidosis Database and Predictive Quantitative Structure-Activity Relationship (QSAR) Models. Toxicology Mechanisms and Methods. 2008 Jan;18(2-3):217–27. doi: 10.1080/15376510701857262.
      参考文献:10.1007/bf02894012
      摘要:Flodh H, Magnusson G. Genesis of foam cells: study in rats after administration of Cloforex. Virchows Arch B Cell Pathol. 1973 Mar 30;12(4):360–6. doi: 10.1007/bf02894012.
      参考文献:10.1007/bf01851451
      摘要:Parwaresch R, Reil GH, Seiler KU. [Studies on animal and organ specificity of chlorphentermine induced morphological alterations (author's transl)]. Res Exp Med (Berl). 1973 Nov 23;161(4):272–88. doi: 10.1007/bf01851451.
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