专利号:RU-1589598-C 优先权日:1987-12-01 标题 :4-hydroxy-2,6-dihydroxyiminocyclohexanone as a parent product for synthesis of 4-hydroxybenzofurazan, and a method of 4-hydroxybenzofurazan synthesis
专利号:US-9751874-B2 优先权日:2014-12-17 标题:Hydroxy containing FXR (NR1H4) modulating compounds 发明人:GEGE CHRISTIAN; KINZEL OLAF; KREMOSER CLAUS; SCHMITT AARON C 权利人:GILEAD SCIENCES INC 摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.
专利号:US-5374766-A 优先权日:1991-02-28 标题 :Ester and method for production thereof as well as hydrolysis process and determination of optical purity using this ester 发明人:SENDA SHUJI; FUKUZAKI EIICHIRO; NAKAZONO YUTAKA; OMATA TETSUO 权利人:NITTO DENKO CORP 摘要:This invention relates to a novel ester which presents as (CF 1) and a method for the production of the same as well as a process for hydrolysis and a method for the determination of an optical purity using this ester, and the object thereof is to provide an intermediate for the synthesis or various natural products, which has high stability, and the optical purity of which can readily be determined, according to the esterification of 1-oxo-5-hydroxymethyl-2-cyclohexene which is unstable to acids and alkalis. (CF1)
专利号:CN-116515782-A 优先权日:2022-01-24 标题:A mutant of amine dehydrogenase and its application in the synthesis of chiral aminoalcohol compounds
专利号:EP-3138831-A1 优先权日:2004-05-21 标 题 :Synthesis of tetracyclines and analogues thereof
专利号:US-4460604-A 优先权日:1976-06-03 标 题 :4-Amino-4-aryl-cyclohexanones 发明人:LEDNICER DANIEL 权利人:UPJOHN CO 摘要:A class of 4-amine-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts. Processes for synthesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.
参考文献:10.1038/ncomms14190 摘要:Meng Q, Hou M, Liu H, Song J, Han B. Synthesis of ketones from biomass-derived feedstock. Nature Communications. 2017 Jan 31;8(1):14190. doi: 10.1038/ncomms14190.