CAS: 13039-56-0; 5-Deoxy-L-Arabinose

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CAS号54253-49-5 L-鼠李糖双(乙砜) | CAS号6748-70-5 L-鼠李糖缩二乙硫醇 | CAS号3615-41-6 α-鼠李糖 | CAS号1352707-53-9 1',3'-propanedi... | CAS号13039-79-7 O5-(toluene-4-s... | CAS号82970-19-2 (2S,3S,4S)-6,6-... | CAS号13039-82-2 2-amino-6-[(1S,... | CAS号22150-76-1 L-生物喋呤 | CAS号2636-52-4 L-普利普林汀

📜L-阿拉伯糖置于吡啶,四氯化硅,硫酸,Palladium 10% On Activated Carbon,氢气,溶剂黄146,三乙胺,Sodium Iodide体系中,用 甲醇,二氯甲烷,水,丁酮 用作溶剂,化学反应 28.5H,反应生成5-脱氧-L-阿拉伯糖
参考文献:一种四氢生物蝶呤关键中间体的制备方法
标题:一种四氢生物蝶呤关键中间体的制备方法
摘要:本发明公开了一种四氢生物蝶呤关键中间体的制备方法.它包括如下步骤:1)缩醛的制备:戊糖与醇混合,进行关环反应,得到缩醛;缩醛与氯化硅混合,进行酯化反应,得到酯;酯与卤化剂进行反应,得到卤代糖;卤代糖进行氢化反应,得到脱氧戊糖;脱氧戊糖与乙酸混合进行开环反应,得到5‑脱氧‑戊糖醛;在惰性气氛中,将苯肼加入5‑脱氧戊糖醛中进行反应,即得到式i所示四氢生物蝶呤关键中间体.本发明反应过程中所用溶剂及试剂价廉易得,原料为天然来源,保证产物的光学纯度.该方法操作简单,成本低廉,有利于工业化生产.

专利信息

专利号:US-8809553-B2
优先权日:2010-06-15
标题:Process for the preparation of pteridine derivatives
发明人：ATTOLINO EMANUELE; MICHIELETTI MARIO; ROSSI DAVIDE; ALLEGRINI PIETRO
权利人:ATTOLINO EMANUELE; MICHIELETTI MARIO; ROSSI DAVIDE; ALLEGRINI PIETRO; DIPHARMA FRANCIS SRL
摘要:The application discloses a process for the preparation of 5-deoxy-L-arabinose of formula (VI); comprising the conversion of a compound of formula (XII); wherein n is 0, 1 or 2; which can be used as intermediate for the synthesis of sapropterin.

专利号:US-3505329-A
优先权日:1968-02-06
标题 :Process for the synthesis of biopterin
发明人：WEINSTOCK JOSEPH
权利人:SMITHKLINE CORP

专利号:US-9365573-B2
优先权日:2012-04-10
标题:Method for synthesizing sapropterin dihydrochloride
发明人：HONG HAO; GAGE JAMES; CHEN CHAOYONG; LU JIANGPING; ZHOU YAN; LIU SHUANGYONG
权利人:ASYMCHEM LAB TIANJIN CO LTD; ASYMCHEM LIFE SCIENCE TIANJIN CO LTD; TIANJIN ASYMCHEM PHARMACEUTICAL CO LTD; ASYMCHEM LAB FUXIN CO LTD; JILIN ASYMCHEM LAB CO LTD; TIANJIN ASYMCHEM PHARMACEUTICAL CO LTD
摘要:Disclosed is a method for synthesizing sapropterin dihydrochloride. The present disclosure reduces a synthesis route of the sapropterin dihydrochloride, introduces a chiral center in an asymmetric synthesis manner, in which a tetrahydrofuran solution containing a samarium catalyst is adopted as a catalyst, and obtains a target compound having a high antimer isomerism value by means of selective catalysis. The yield is improved, raw materials are cheap and readily available, and the cost is significantly reduced, hence providing an effective scheme for mass industrial production of the sapropterin dihydrochloride.

专利号:US-9371326-B2
优先权日:2012-04-10
标题 :Method for synthesizing sapropterin dihydrochloride
发明人：HONG HAO; GAGE JAMES; CHEN CHAOYONG; LU JIANGPING; ZHOU YAN; LIU SHUANGYONG
权利人:ASYMCHEM LAB TIANJIN CO LTD; ASYMCHEM LIFE SCIENCE TIANJIN CO LTD; TIANJIN ASYMCHEM PHARMACEUTICAL CO LTD; ASYMCHEM LAB FUXIN CO LTD; JILIN ASYMCHEM LAB CO LTD; JILIN ASYMCHEM LAB CO LTD
摘要:Disclosed is a method for synthesizing sapropterin dihydrochloride. The present disclosure reduces a synthesis route of the sapropterin dihydrochloride, and resolves a racemate intermediate or an intermediate having a low antimer isomerism value by using a chiral resolving reagent, thereby obtaining an intermediate having a high antimer isomerism value. Raw materials are cheap and readily available, and the cost is significantly reduced, hence providing an effective scheme for mass industrial production of the sapropterin dihydrochloride.