CAS: 105827-91-6; 2-Chloro-5-(Chloromethyl)Thiazole

相似化合物

33342-65-3 131052-44-3 105315-40-0

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CAS号52829-72-8 5-METHYLENE-1,3... | CAS号14214-31-4 2-氯丙烯基异硫氰酸酯 | CAS号145015-15-2 2-氯-5-羟基甲基噻唑 | CAS号196406-44-7 3-chloro-1-isot... | CAS号764-28-3 azoisobutyric a... | CAS号57-06-7 异硫氰酸烯丙酯 | CAS号33342-65-3 2-氯-5-甲基噻唑 | CAS号188988-52-5 N-(2-chloroprop... | CAS号1074-82-4 邻苯二甲酰亚胺钾盐 | CAS号339018-41-6 4-((2-CHLOROTHI... | CAS号145015-15-2 2-氯-5-羟基甲基噻唑 | CAS号338393-48-9 4-[(2-CHLORO-1,... | CAS号120740-08-1 (2-氯噻唑-5-基)甲胺 | CAS号434902-57-5 bis{(2-chloroth... | CAS号153719-23-4 阿克泰

天然芥菜籽油置于n-氯代丁二酰亚胺,磺酰氯体系中,用 二氯甲烷 用作溶剂,以48%的收率获得2-氯-5-氯甲基噻唑
参考文献:Method For Producing 2-Chloro-5-Chloromethyl-1,3-Thiazole
标题:Method For Producing 2-Chloro-5-Chloromethyl-1,3-Thiazole
摘要:一种制备2-氯-5-氯甲基-1,3-噻唑的方法,其中式ch2=ch-ch2-Ncs的烯丙基异硫氰酸酯在-40oc至+30oc的温度下,在反应条件下为惰性的溶剂中,与每摩尔烯丙基异硫氰酸酯1至2摩尔的氯化剂反应;向所得反应混合物中,在0oc至所用溶剂的沸点的反应温度下,加入每摩尔烯丙基异硫氰酸酯1至5摩尔的氧化剂,然后从反应混合物中分离出2-氯-5-氯甲基-1,3-噻唑,并可选择通过结晶转化为高纯度的2-氯-5-氯甲基-1,3-噻唑.

专利信息

专利号:US-5811555-A
优先权日:1995-11-22
标题:Method for substitution of an amino group of a primary amine by a chlorine atom and a synthetic method by application thereof
发明人：WAKASUGI TAKASHI; MIYAKAWA TADASHI; TANONAKA TAKAYUKI
权利人:KUREHA CHEMICAL IND CO LTD
摘要:This invention relates to methods for substitution of an amino group of a heterocyclic primary amine by a chlorine atom and synthesis of 2-chloro-5-methylthiazole and its derivatives by application thereof. n Typically, a heterocyclic primary amine and sodium nitrite are caused to react in the presence of hydrochloric acid, followed by heating the formed diazonium base at 30°-100° C. in the presence of an equimolar or more of hydrochloric acid to substitute the amino group by the chlorine atom. Further, 2-amino-5-methylthiazole and sodium nitrite are caused to react in the presence of hydrochloric acid, followed by heating the formed diazonium base at 30°-100° C. in the presence of an equimolar or over of hydrochloric acid to give 2-chloro-5-methylthiazole. Then, the resultant 2-chloro-5-methylthiazole is caused to react with a chlorinating agent to give 2-chloro-5-chloro-methylthiazole.

专利号:RU-2202544-C2
优先权日:1997-08-18
标 题:Method of synthesis of derivatives of substituted 2-nitroguanidine and methods of synthesis of in- termediate compounds

专利号:US-2023010886-A1
优先权日:2019-09-23
标 题 :Shp2 inhibitors and uses thereof
发明人：XIE YINONG; BABISS LEE E
权利人:SUZHOU PUHE BIOPHARMA CO LTD
摘要:Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.

专利号:CN-217068793-U
优先权日:2022-03-23
标 题:A Novel Reactor for Synthesis of Thiamethoxam

专利号:US-11369113-B2
优先权日:2017-10-27
标题:Vector control compositions, methods and products utilizing same
发明人：HUETER OTTMAR FRANZ; HOPPE MARK; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; FEDOU NICOLAS; GODINEAU EDOUARD; WEGE PHILIP; MAIENFISCH PETER
权利人:SYNGENTA PARTICIPATIONS AG
摘要:The present inventions concerns use of a specific methoxyacrylate compound to control mosquitoes, and vector control products comprising that methoxyacrylate compound, in particular the invention relates to a substrate, to a composition, for controlling mosquitoes, and to a specific methoxyacrylate compound, processes for the synthesis of mosquitocidal methoxyacrylate compounds and new intermediates.

专利号:CN-213050626-U
优先权日:2020-06-11
标 题:Continuous Vertical Spiral Tube Reactor for Synthesis of 2-Chloro-5-Chloromethylthiazole