CAS: 95-95-4; 2,4,5-Trichlorophenol

该化合物是一种有机化合物,其特点是氯化酚结构;它对于在有机溶剂中可溶解但水溶性有限的黄色黄固体来说,是无色的;TCP以强烈的抗菌性和抗芬酸特性而著称,它历来使它作为农药和消毒剂有用;然而,由于对环境和健康的关注,它的使用受到限制,因为它被归类为潜在的致癌物,可能对水生生物有毒;该化合物的熔点一般属于特定范围,并表现出独特的气味;就再活动而言,TCP可以发生各种化学反应,包括核分裂替代和氧化;在许多国家,由于其在环境中的持久性和生物累积潜力,其生产和使用受到管制;在处理TCP时,安全防范是不可或缺的,因为接触可能会导致不良的健康影响,包括皮肤刺激和呼吸道问题.

结构式图片

欧盟法规

统一分类与标签ECHA物质工作场所安全标识要求ECHA物质C&L通报REACH预注册废弃物危险特性清单

上下游产品

CAS号583-78-8 2,5-二氯苯酚 | CAS号16965-08-5 碳酸叔丁基-2,4,5-三氯苯酯 | CAS号6130-75-2 2,4,5-三氯苯甲醚 | CAS号87-86-5 五氯苯酚 | CAS号40932-60-3 3,5,6-三氯水杨酸 | CAS号95-94-3 1,2,4,5-四氯苯 | CAS号320-72-9 3,5-二氯水杨酸 | CAS号121795-04-8 2-amino-4-(etho... | CAS号67-56-1 甲醇 | CAS号58286-60-5 methyl 2,4,5-tr... | CAS号40321-76-4 1,2,3,7,8-五氯二苯并对二恶英 | CAS号57653-85-7 1,2,3,6,7,8-六氯二... | CAS号39227-28-6 1,2,3,4,7,8-六氯二... | CAS号1746-01-6 硫丙磷 | CAS号39001-02-0 1,2,3,4,6,7,8,9... | CAS号4524-78-1 6-溴-2,4,5-三氯苯酚 | CAS号19408-74-3 1,2,3,7,8,9-六氯二... | CAS号51207-31-9 2,4,7,8-四氯二苯并呋喃 | CAS号35822-46-9 1,2,3,4,6,7,8-七... | CAS号3268-87-9 1,2,3,4,6,7,8,9...

合成工艺路线路线简述

  • 合成目标产物 2,4,5-Trichlorophenol 主要起始原料 2,4,5-Trichloroaniline
  • (文献来源)合成步骤主要原料 2,4,5-Trichloroaniline
五氯酚置于四乙基溴化铵体系中,用 甲醇 作为反应溶剂,化学反应生成 2,4,5-三氯苯酚
参考文献:Electroreduction Of Organic Compounds,34 [1]. Cathodic Dehalogenation Of Chloroarenes With Electron-Donating Substituents
标题:Electroreduction Of Organic Compounds,34 [1]. Cathodic Dehalogenation Of Chloroarenes With Electron-Donating Substituents
摘要:氯代芳烃的电化学还原与供电取代基(如氯甲苯,-苯甲醚和-酚)进行研究.在铅或碳阴极下,在各种溶剂支持电解质的电位静态和电流静态条件下进行制备电解.在适当条件下,可能对具有两个或更多氯取代基的化合物进行部分和主要区域选择性的去氯化.尤其是在对位,替换一个单独的氯取代基是困难的.因此,高度有毒和持久的寡氯衍生物可以转化为氯化程度较低的问题较少的化合物.通过电还原,也可以显着降低受氯化酚和nitrofen®污染的土壤提取物等实际材料的氯含量.
DOI:10.1515/znb-2003-1206

海关参考信息

专利信息


专利号:WO-0100609-A1
优先权日:1999-06-29
标题:Method for synthesis of n-homocysteine thiolactonyl retinamide
发明人:KAZIMIR MICHAEL; WILSON RAY E II
权利人:UNIV BAYLOR; KAZIMIR MICHAEL; WILSON RAY E II
摘要:The present invention describes methods of synthesis for N-homocysteine thiolactonyl retinamide (thioretinamide), a compound that has anticancer and antiatherogenic properties. The present invention further describes methods for the synthesis of N-homocysteine thiolactonyl retinamido cobalamin (thioretinaco), a compound that has potential anticancer, antineoplastic, antiviral, and antiatherogenic properties.

专利号:US-4242256-A
优先权日:1977-03-15
标 题 :Synthesis of peptide analogues
发明人:SHARPE ROBERT; SZELKE MICHAEL
权利人:SHARPE ROBERT; SZELKE MICHAEL
摘要:Compounds being analogues of a dipeptide in which the nitrogen atom of the linking amide group of the dipeptide is replaced by trivalent group ##STR1## and in which, optionally, the carbonyl function of this linking group is replaced by the divalent group --CH 2 -- are of value in the synthesis of isosterically modified peptides.

专利号:US-4939112-A
优先权日:1988-10-06
标 题:Catalyst for synthesis of vesicular phenoxy resins
发明人:BENNETT EVERETT W
权利人:JAMES RIVER PAPER CO
摘要:A catalyst for synthesis of vesicular phenoxy resins is disclosed. The catalyst includes a water-insoluble complex of a hydric phenol and a quaternary ammonium or phosphonium salt of the hydric phenol. Preferably, the hydric phenol is an intermediate of the phenoxy resin being produced. Dihydric phenols, such as sulfonyldiphenol are preferred. The invention further relates to a reaction medium for polymerization of phenoxy resins including the above-described catalyst and a solvent medium capable of dissolving the phenoxy resins and otherwise not interfering with the polymerization reaction. The solvent medium is advantageously free of toxic Methyl Cellosolve.

专利号:US-7696389-B2
优先权日:2006-03-24
标 题 :Method for reducing microcontaminants during synthesis of pentachlorophenol
发明人:SAVAGE PHILLIP E; YU JIANLI
权利人:UNIV MICHIGAN
摘要:A method for reducing contaminants during synthesis of pentachlorophenol includes providing a phenol-based starting material and a catalyst, which form a reaction mixture. A chlorine flow is introduced so that it is in contact with the reaction mixture, and the starting material and chlorine are reacted via a temperature-programmed reaction. The chlorine flow is terminated at a predetermined temperature prior to an end of the temperature-programmed reaction and/or at a point where the yield of pentachlorophenol is less than about 95%.

专利号:US-6287818-B1
优先权日:2000-04-25
标 题 :Method for synthesis of N-homocysteine thiolactonyl retinamido cobalamin and uses thereof
发明人:KAZIMIR MICHAL; WILSON II F RAY
权利人:UNIV BAYLOR
摘要:The present invention describes methods for the synthesis of N-homocysteine thiolactonyl retinamido cobalamin (thioretinaco), a compound that has potential anticancer, antineoplastic, antiviral, and antiatherogenic properties.

专利号:US-7189849-B2
优先权日:1997-02-10
标 题:Synthesis of acyclic nucleoside derivatives
发明人:LEANNA M ROBERT; RASMUSSEN MICHAEL; HANNICK STEVEN M; TIEN JIEN-HEH J; LUKIN KIRILL A; TIAN ZHENPING; CHANG SOU-JEN; CURTY CYNTHIA B; NARAYANAN BIKSHANDARKOIL A; BELLETTINI JOHN; SHELAT BHADRA; SPITZ TIFFANY
权利人:MEDIVIR AB
摘要:Novel processes towards the synthesis of the antiviral valomaciclovir stearate in which an esterified guanine acetal is reduced to the corresponding alcohol, reacted with an activated amino acid and N-deprotected. The esterified guanine acetal is prepared from a 9-guanine derivative bearing an acyclic hydroxymethylbutylacetal. The processes are amendable to one-pot reactions.
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主要参考文献

参考标题:1-Propanephosphonic Acid Cyclic Anhydride (T3P) As An Efficient Promoter For The Lossen Rearrangement: Application To The Synthesis Of Urea And Carbamate Derivatives
作者:Vommina Sureshbabu,Basavalingappa Vasantha,Hosahalli Hemantha |发布日期:2010.9
摘要:The Synthesis Of Hydroxamic Acids Starting From Carboxylic Acids Employing 1-Propanephosphonic Acid Cyclic Anhydride (T3P) Activation Is Described. Application Of Ultrasonication Accelerates This Conversion. Further, The T3P Has Also Been Employed To Activate The Hydroxamates, Leading To Isocyanates Via The Lossen Rearrangement. The Isocyanates Were Trapped With Suitable Nucleophiles To Afford The

合成参考文献


参考文献:10.1177/0734242x11411232
摘要:Yazici R, Sekman E, Top S, Varank G, Bilgili MS. Degradation of phenolic compounds in aerobic and anaerobic landfills: a pilot scale study. Waste Manag Res. 2012 May;30(5):542–50. doi: 10.1177/0734242x11411232.
参考文献:10.1002/cssc.201100108
摘要:Ren Q, Hou Z, Wang Y, Zhang H, Yang S. Noncovalent Interactions of Metalloporphyrins with Polyamidoamine Dendrimers Give Rise to Efficient Catalytic Systems for H2O2 Oxidation of Trichlorophenol in Water. ChemSusChem. 2011 Jul 12;4(8):1063–7. doi: 10.1002/cssc.201100108.
参考文献:10.1007/s00425-011-1474-0
摘要:Hall D, Kim KH, De Luca V. Molecular cloning and biochemical characterization of three Concord grape (Vitis labrusca) flavonol 7-O-glucosyltransferases. Planta. 2011 Dec;234(6):1201–14. doi: 10.1007/s00425-011-1474-0.
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