CAS: 875781-15-0; 5-Bromo-2-Fluoronicotinaldehyde

相似化合物

29241-66-5 1256821-83-6 931105-37-2

上下游产品

CAS号2591-86-8 1-甲酰哌啶 | CAS号766-11-0 5-溴-2-氟吡啶 | CAS号109-94-4 甲酸乙酯 | CAS号1111637-73-0 1-(5-溴-2-氟吡啶-3-基)乙醇 | CAS号875781-17-2 5-溴-1H-吡唑并[3,4-b]吡啶 | CAS号1111637-74-1 1-(5-溴-2-氟-3-吡啶)乙酮 | CAS号882670-89-5 6-溴吡啶并[2,3-d]嘧啶-2-胺

2-氟-5-溴吡啶置于正丁基锂,Lithium Diisopropyl Amide,哌啶-1-甲醛,柠檬酸体系中,用 四氢呋喃,正己烷,二氯甲烷,水 作为反应溶剂,化学反应 1.77H,以52%的收率获得产物2-氟-5-溴吡啶-3-甲醛
参考文献: Fused Ring Heterocycle Kinase Modulators[fr] Modulateurs Heterocycliques A Cycles Fusionnes Pour Les Kinases
标题: Fused Ring Heterocycle Kinase Modulators[fr] Modulateurs Heterocycliques A Cycles Fusionnes Pour Les Kinases

专利信息

专利号:EP-3070087-B1
优先权日:2011-08-05
标题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors

专利号:EP-3070087-A1
优先权日:2011-08-05
标 题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors

专利号:ES-2733096-T3
优先权日:2011-08-05
标题:Intermediaries for the synthesis of cyclic P1 linkers as XIA factor inhibitors

专利号:US-7772246-B2
优先权日:2007-08-01
标题:Pyrazole compounds as RAF inhibitors
发明人：CUI JINGRONG JEAN; DEAL JUDITH GAIL; GU DANLIN; GUO CHUANGXING; JOHNSON MARY CATHERINE; KANIA ROBERT STEVEN; KEPHART SUSAN ELIZABETH; LINTON MARIA ANGELICA; MCALPINE INDRAWAN JAMES; PAIRISH MASON ALAN; PALMER CYNTHIA LOUISE
权利人:PFIZER
摘要:The present invention is directed to compounds of Formula (I), n nand to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.