CAS: 766-39-2; 3,4-Dimethylfuran-2,5-Dione

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CAS号40274-33-7 3,4-dimethyl-N-... | CAS号108-31-6 顺酐 | CAS号6631-37-4 2-苯基氨基吡啶 | CAS号89068-54-2 3,4-dimethyl-1-... | CAS号875655-28-0 N-benzyl-5,5-di... | CAS号44873-88-3 dimethyl-fumaro... | CAS号110-16-7 马来酸 | CAS号504-29-0 2-氨基吡啶 | CAS号64-17-5 乙醇 | CAS号4282-33-1 3,4-呋喃二羧酸二甲酯 | CAS号21788-49-8 2-Butenedioic a... | CAS号27697-13-8 methylitaconic acid | CAS号123-56-8 丁二酰亚胺 | CAS号34584-69-5 3,6-二氯-4,5-二甲基哒嗪 | CAS号25060-18-8 2,3-二甲基奎札因 | CAS号30614-77-8 3,4-呋喃二甲酸二乙酯 | CAS号608-40-2 (2R,3S)-2,3-二甲基琥珀酸 | CAS号631-64-1 二溴乙酸 | CAS号5754-17-6 4,5-二甲基哒嗪-3,6-二酮

Cantharidin 反应生成 2,3-二甲基马来酸酐
参考文献:V. Bruchhausen; Bersch,Archiv Der Pharmazie,1928,P. 701
标题:V. Bruchhausen; Bersch,Archiv Der Pharmazie,1928,P. 701

专利信息

专利号:US-7094805-B2
优先权日:2001-12-14
标 题 :Total synthesis of merrilactone A
发明人：DANISHEFSKY SAMUEL J; BIRMAN VLADIMIR B
权利人:UNIV COLUMBIA
摘要:This invention provides a total synthesis of Merrillactone and Merrilactone analogues for use as neurotrophic agents in the treatment of neurodegenerative diseases. The invention also provides intermediates for use in the synthesis of Merrilactone and its analogues.

专利号:US-12221452-B2
优先权日:2017-10-04
标题:Synthesis of cantharidin
发明人：DAVIDSON MATTHEW GENE; EKLOV BRIAN MATTHEW; WUTS PETER; LOERTSCHER BRAD MELVIN; SCHOW STEVEN R
权利人:VERRICA PHARMACEUTICALS INC
摘要:The invention provides synthetic methods for the preparation of cantharidin and analogs thereof. In one aspect, the invention provides an improved Diels-Alder cycloaddition to generate a key intermediate en route to cantharidin and analogs thereof. In certain embodiments, the new Diels-Alder reaction involves reacting Compound (2) in the presence of furan, and in the absence of acid or increased pressure, in an aprotic polar solvent with slight warming, to yield Compound (1) in favorable yield and exo-endo ratio. In another aspect, the invention also provides a new Diels-Alder reaction between compounds of Formula (III) and furan to yield compounds of Formula (IV), which can then be transformed into cantharidin or analogs thereof. In yet another aspect, the invention describes a new palladium-mediated carbonylation providing another key intermediate en route to cantharidin and analogs thereof. In addition to synthetic methods, present invention also provides compounds (i.e., intermediates) useful in the synthesis of cantharidin and analogs thereof. Compounds provided herein may have biological activity, and therefore may be used in the treatment of diseases or conditions (e.g., infectious diseases and skin conditions).

专利号:US-2021220331-A1
优先权日:2016-05-03
标题:Inhibitors of ires-mediated protein synthesis
发明人：GERA JOSEPH F; LICHTENSTEIN ALAN; JUNG MICHAEL E; LEE JIHYE; HOLMES BRENT; BENAVIDES-SERRATO ANGELICA
权利人:UNIV CALIFORNIA; THE UNITED STATE GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
摘要:This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors.

专利号:US-2009131498-A1
优先权日:2005-01-18
标题 :Enantioselective Synthesis of Merrilactone and Its Analogs
发明人：DANISHEFSKY SAMUEL J; MENG ZHAOYANG; BIRMAN VLADIMIR
权利人:DANISHEFSKY SAMUEL J; MENG ZHAOYANG; BIRMAN VLADIMIR
摘要:This invention provides a method of synthesizing enantioenriched merrilactone A and enantiopure merrilactone A, as well as an improved method of synthesizing racemic merrilactone. This invention also provides intermediate compounds and methods of treating peripheral neuropathies

专利号:US-4298752-A
优先权日:1980-09-19
标题:Cycloadduct precursors of cantharidin and method
发明人：DAUBEN WILLIAM G; KESSEL CARL R; TAKEMURA KAZUO H
权利人:UNIV CALIFORNIA
摘要:Novel cycloadducts are provided which may be formed between furan and 2,5-dihydrothiophene-3,4-dicarboxylic anhydride at elevated pressure. One of these cycloadducts is useful in a synthesis of cantharidin. Another yields a novel isomeric cantharidin.

专利号:WO-2025124564-A1
优先权日:2023-12-15
标题:Polyester synthesis based on aspartic acid modification
发明人：ZHANG KECHUN; CHEN XI; LEI TENGFEI; LIU SHENGYANG
权利人:MINT BIOTECHNOLOGIES CO LTD
摘要:Provided in the present invention is polyester synthesis based on aspartic acid modification. A monomer of a unique structure of an imide ring is obtained based on aspartic acid and a dibasic acid likely to be cyclized, the monomer is based on the aspartic acid, can be derived from biomass, is low in cost and renewable, meets the requirement of sustainable development, and the unique structure of the monomer can regulate and control various properties of polyester materials, such as the mechanics, temperature resistance, hydrophilicity and hydrophobicity, and crystallization.