CAS: 74378-10-2; 2,6-Dimethyl-4-(2-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylic Acid

上下游产品

nifedipine Bis(tert-butyl)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridin-3,5-dicarboxylat

📜硝苯地平置于三氯化硼体系中,用 二氯甲烷 作为反应溶剂,化学反应 1.5H,以100 Mg的收率获得产物2,6-二甲基-4-(2-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸
参考文献:Quantitative Determination Of Nifedipine And Its Metabolite In Hamster Plasma By Radio-Gas Chromatography.
标题:Quantitative Determination Of Nifedipine And Its Metabolite In Hamster Plasma By Radio-Gas Chromatography.
摘要:描述了定量分析仓鼠血浆中[14C]硝苯地平及其代谢物的特定放射气相色谱方法.使用 1.5% Ov-1 的柱填料可以精确分析纳克量的硝苯地平,而无需任何热分解.通过追踪仓鼠静脉内给药后硝苯地平及其吡啶代谢物的血浆浓度的时间过程,证明了该方法的有效性.使用本研究中合成的标记化合物可以测量低至 5 Ng/ml 的硝苯地平血浆水平.
DOI:10.1248/cpb.36.3000

专利信息

专利号:US-2010184989-A1
优先权日:2007-03-12
标 题 :De Novo Synthesis of Conjugates
发明人：RIGGS-SAUTHIER JENNIFER; DENG BO-LIANG; REN ZHONGXU; ZHANG WEN; GU XUYUAN; DUARTE FRANCO J
权利人:NEKTAR THERAPEUTICS
摘要:The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.

专利号:AU-2008226820-A1
优先权日:2007-03-12
标题 :De novo synthesis of conjugates

专利号:CA-2679473-A1
优先权日:2007-03-12
标题:De novo synthesis of conjugates

专利号:EP-1532110-B1
优先权日:2002-07-01
标题 :Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine)

专利号:JP-2010521465-A
优先权日:2007-03-12
标 题 :De novo synthesis of complex

专利号:JP-2013253104-A
优先权日:2007-03-12
标题:De novo synthesis of complex