CAS: 72093-04-0; 3-Chloro-4-Methylpyridine

该化合物是一种七环有机化合物,在三处有一个替代氯的替代品,在环的四处有一个甲基组别,由于反应性卤素和稳定的芳香结构,这种多用途中间体广泛用于制药和农用化学合成.其电排氯组会增强电益替代反应活动,而甲基组别则会有助于消毒和电子调节.该组别是开发活性成分,催化剂和特殊化学品的关键基石.高纯度可以满足严格的工业要求,确保合成应用的一贯性能.

英文名称3-Chloro-4-Methylpyridine
中文名称3-氯-4-甲基吡啶
IUPAC名称3-chloro-4-methylpyridine
其它别名Pyridine, 3-Chloro-4-Methyl-; Vlnxnjmhlzfecv-Uhfffaoysa-N; 3-Chloro-4-Methylpyridine; 3-Chloro-4-Methyl-Pyridine; 3-Chloro-4-Methylpyridin
CAS编号72093-04-0
MFCD编号:MFCD04114245
EINECS号:628-375-1
分子式:C6H6ClN
分子量:127.57
产品CID: 2488352
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: VLNXNJMHLZFECV-UHFFFAOYSA-N
InChI=1S/C6H6ClN/c1-5-2-3-8-4-6(5)7/h2-4H,1H3…
计算化学: 氢键受体数1.0氢键供体数0可旋转键数0

相似化合物

100868-46-0 1379109-40-6 68325-15-5

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼损伤类别1
易燃液体类别4
警示词Danger(危险)
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H318 |造成严重眼损伤.
H227 |可燃液体
防范说明P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501
危险等级3
UN编号1993.0
危险品标志Xi,Xn
包装等级Ⅲ
安全声明26-36/37/39-39
危险类别码36/37/38-41-37/38-22
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号108-89-4 4-甲基吡啶 | CAS号626-60-8 3-氯吡啶 | CAS号74-88-4 碘甲烷 | CAS号19352-29-5 3-苯基-4-甲基吡啶

合成工艺路线路线简述

3,4-二氢-4-甲基-2-甲氧基-2H-吡喃置于氯体系中,化学反应生成 3-氯-4-甲基吡啶,Alkaline Earth Salt Of/the/ Methylsulfuric Acid
参考文献:De946802
标题:De946802

海关参考信息

2933310010-吡啶
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-8853410-B2
优先权日:2009-04-30
标题:Process for preparing substituted isoxazoline compounds and their precursors
发明人：RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN
权利人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN; BASF SE
摘要:The present invention relates to a new method of preparing halogenated styrene compounds of formula (VIII) n nwhich are precursors in the process of synthesis of substituted isoxazoline compounds of formula (I)n n nwherein R 1 to R 5 , R 8 and R 9 are described as in the description.n n The present invention relates further to the synthesis of compounds of formula (I) starting from acetophenones. The desired styrenes of formula are prepared from the appropriate substituted acetophenone. Asides bromo anilines react with formoxime. Obtained oximes undergo a cycloaddition with the styrenes and give isoxazolines. Compounds of formula (I) can then be prepared in a palladium catalyzed carbonylative amination reaction of the isoxazolines.

专利号:WO-2024068976-A1
优先权日:2022-09-29
标题 :Azole derivatives as shp2 inhibitors
发明人：PETROCCHI ALESSIA; MONTALBETTI CHRISTIAN; DI FABIO ROMANO; CIAMMAICHELLA ALINA; ROSSETTI ILARIA
权利人:IRBM S P A; C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING
摘要:The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase. Compounds of the invention can be used for the treatment of disorders associated with SHP2 deregulation. The present invention also relates to pharmaceutical compositions containing said compounds and to their method of synthesis.