CAS: 703-12-8; 4-Bromo-N-Methylbenzenesulfonamide

上下游产品

methylamine hydr°Chloride 4-bromobenzenesulfonyl chloride 7H7BrN2O4SC7H7BrN2O4S 6H5BrNO2S(1-)*Na(1+)C6H5BrNO2S(1-)*Na(1+) N-Methyl-(α-carbomethoxybenzyl)-p-brombenzolsulfonamid N-Methyl-(α-phenyl-β-p-toluolsulfonoxyethyl)-p-brombenzolsulfonamid (4-[N-methylsulfamoyl]phenyl)boronic acid N-Methyl-N-(α-styryl)-p-brombenzolsulfonamid

📜Methyl N-(4-Bromobenzene)Sulfonyl-L-Serinate置于n-溴代丁二酰亚胺(Nbs),Pyridinium Polyhydrogenfluoride,Potassium Carbonate,三乙胺体系中,用 二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 46.0H,反应生成 N-甲基-4-溴苯磺酰胺
参考文献:的halofluorination N-保护的α,β脱氢α氨基酸酯-Aα氟-α-氨基酸衍生物的简便合成法
标题:的halofluorination N-保护的α,β脱氢α氨基酸酯-Aα氟-α-氨基酸衍生物的简便合成法
摘要:N-保护的脱氢氨基酸甲酯已在卤代氟化反应条件下转化为α-氟-β-卤代氨基酸衍生物.研究了底物的氮保护基和亲电子的卤化氢对反应结果和所得产物稳定性的影响.此外,在自由基条件下卤素取代基(cl或br)的还原提供了后续反应的可能性.然而,亲核取代反应失败.
DOI:10.1016/j.Jfluchem.2016.06.006

专利信息

专利号:US-2007275968-A1
优先权日:2004-09-07
标 题 :Substituted Biphenyl Derivative
发明人：KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
权利人:KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
摘要:The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: n nwherein n R 1 represents a C 6 -C 10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C 1 -C 6 alkyl)amino group, a di-(C 1 -C 6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C 1 -C 6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R 2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R 3 represents a C 1 -C 6 alkyl group, and so on; and R 4 represents a C 1 -C 6 alkyl group, and so on.