CAS: 67531-68-4; 3-(Ethoxycarbonyl)Phenylisocyanate

上下游产品

phosgene 3-aminobenzoic acid ethyl ester 3-{3-[1-(Isopropyl-phenyl-carbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-3-yl]-ureido}benzoic acid ethyl ester

📜3-氨基苯甲酸乙酯置于硫酸体系中,用 甲苯 作为反应溶剂,化学反应 0.5H,反应生成 3-(乙氧基羰基)苯异氰酸酯
参考文献:Organosilicon Synthesis Of Isocyanates: Iii. Synthesis Of Aliphatic,Carbocyclic,Aromatic,And Alkylaromatic Isocyanatocatboxylic Acid Esters
标题:Organosilicon Synthesis Of Isocyanates: Iii. Synthesis Of Aliphatic,Carbocyclic,Aromatic,And Alkylaromatic Isocyanatocatboxylic Acid Esters
摘要:A Series Of Aminoacid Esters Was Prepared By Treating The Aminoacid Suspensions In Ethanol With Thionyl Chloride. Best Conversion Of Aminoacid Esters To Corresponding Isocyanates Was Achieved In The Case Of Aromatic And Carbocyclic Aminoesters By Phosgeneation Of Their N-Silyl Derivatives,And In The Case Of Aliphatic And Alkylaromatic Aminoesters By Phosgeneation Of O-Silyl Or N,O-Bissilylurethanes On Their Basis. In The Last Case Additional Step Of Esterification Of The By-Products Isocyanatoalkylcarboxylic Acid Chlorides Is Reqired After Phosgeneation. Unusual Generation Of Cynnamates And Intramolecular N-> O-Migration Of Trimethylsilyl Group In The Solutions Of Silylated Alkylaromatic Beta-Aminoacid Esters Were Found.
DOI:10.1134/s1070363206070115

专利信息

专利号:RU-2124009-C1
优先权日:1992-01-21
标题 :Derivatives of 1,5-benzodiazepine, method of their synthesis, pharmaceutical composition