CAS: 656-32-6; 1-(2-Fluorophenyl)-2-Thiourea

该化合物是一种有机化合物,其特点是存在二氟苯基双氟苯乙烯功能组;其分子结构具有硫尿亚组(NH-C(=S)-NH)-HH-联苯环的特征,该组在正方形位置以氟原子替换.该化合物一般是白色到白色的固体,在极地有机溶剂中可溶解.它具有硫素的典型特性,包括能够参与各种化学反应,如核循环替代和凝聚反应.N-(2-氟联)硫尿拉也可能展示生物活动,使其对药物研究感兴趣.其化学文摘社编号为656-32-6,便于在化学数据库中识别.与许多硫尿素一样,必须谨慎处理该化合物,并注意潜在的毒性和环境关切.在实验室环境中与该物质打交道时,应注意适当的安全措施.

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CAS号38985-64-7 异硫氰酸(2-氟苯)酯 | CAS号73999-10-7 N-(o-fluorophen... | CAS号333-20-0 硫氰酸钾 | CAS号51085-49-5 2-氟苯胺盐酸盐 | CAS号348-54-9 邻氟苯胺 | CAS号71232-23-0 (2-fluorophenyl... | CAS号20358-06-9 2-氨基-4-氟苯并噻唑 | CAS号71232-23-0 (2-fluorophenyl... | CAS号82636-12-2 5-Pyrimidinecar...

合成工艺路线路线简述

    📜2-Fluorophenyl Dithiocarbamic Acid Triethylammonium置于ammonium Hydroxide,碳酸氢钠,Tetrapropylammonium Tribromide体系中,用 水,乙酸乙酯 作为反应溶剂,化学反应 0.17H,反应生成 1-(2-氟苯基)-2-硫脲
    参考文献:使用环境友好的试剂四丙基三溴化铵从二硫代氨基甲酸酯盐中新颖合成一锅法合成异硫氰酸酯和氰胺.
    标题:使用环境友好的试剂四丙基三溴化铵从二硫代氨基甲酸酯盐中新颖合成一锅法合成异硫氰酸酯和氰胺.
    摘要:描述了在温和,有效且无毒的三溴化四铵铵存在下,由它们各自的胺合成异硫氰酸酯和氰胺的高效简单方法.试剂的高环境可接受性,成本效益和高产率是该方法的重要属性.
    DOI:10.17344/acsi.2017.3342

    专利信息


    专利号:US-2008004415-A1
    优先权日:2004-05-03
    标题 :Non-linear optically active molecules, their synthesis, and use
    发明人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B
    权利人:OPTIMER PHOTONICS INC
    摘要:In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a Ï€-donor conjugated to a Ï€-acceptor through a Ï€-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.

    专利号:US-2012059163-A1
    优先权日:2005-04-28
    标题 :Non-linear opticaly active molecules, their synthesis, and use
    发明人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B
    权利人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B; OPTIMER PHOTONICS INC
    摘要:In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a Ï€-donor conjugated to a Ï€-acceptor through a Ï€-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.

    专利号:US-5998399-A
    优先权日:1993-03-23
    标题 :Guanidine derivatives useful in therapy as inhibitors of nitric oxide synthetase
    发明人:MACDONALD JAMES E; GENTILE ROBERT; MURRAY ROBERT J
    权利人:ASTRA AB
    摘要:Method of treating or reducing the risk of human disease or condition in which the synthesis or oversynthesis of nitric oxide forms a contributory part wherein a therapeutically effective amount of the compound of formula (I) as defined in the specification is administered to a person suffering from or susceptible to such disease or condition.

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    合成参考文献


    参考文献:10.1107/s010827019800242x
    摘要:Steiner T. N—H...S and N-H...Ph Hydrogen Bonding in 1-(2-Fluorophenyl)thiourea. Acta Crystallogr C Cryst Struct Commun. 1998 Aug 15;54(8):1121–3. doi: 10.1107/s010827019800242x.
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