CAS: 65145-13-3; 2-Fluoro-4-Hydroxybenzoic Acid

上下游产品

2-氟-4-甲氧基苯甲酸 2-Fluoro-4-Methoxy-Benzoic Acid 394-42-3
2-氟-4-羟基苯甲酸乙酯 Ethyl-2-Fluoro-4-Hydroxy-Benzoate 217978-01-3
2-氟-4-丙氧基苯甲酸 2-Fluoro-4-Propoxybenzoic Acid 203115-96-2
2-氟-4-甲氧基苯甲醛 2-Fluoro-4-Methoxy-Benzaldehyde 331-64-6
3-Chloro-2-Fluoro-4-Hydroxybenzoic Acid 860296-15-7
2,4-二氟苯甲酸 2,4-Difluoro-Benzoic Acid 1583-58-0

3-氟苯酚置于咪唑,五甲基二乙烯三胺,仲丁基锂体系中,用 四氢呋喃,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 22.0H,反应生成 2-氟-4-羟基苯甲酸
参考文献:将核心化合物转化为积木:区域化学穷举功能化的概念
标题:将核心化合物转化为积木:区域化学穷举功能化的概念
摘要:在模型研究中,3-氟苯酚和 3-氟吡啶通过相应的有机金属中间体转化为相应羧酸的所有可能的区域异构体.正如对调查结果进行概括的尝试所揭示的那样,一套有限的原则和方法足以应对所有性病.场景.用于区域化学的最有价值和通用的工具.多种底物模式的详尽功能化是可选的位点选择性金属化(通过试剂/底物匹配或外围配位控制),使用激活或拥塞保护基团和碱性梯度驱动的重卤素迁移(随后是卤素/金属排列).[在 Scifinder (R) 上]
DOI:10.1002/ejoc.200400895

专利信息

专利号:WO-0120995-A9
优先权日:1999-09-23
标题:Compounds directed against pilus biogenesis and activity in pathogenic bacteria; methods and compositions for synthesis thereof
发明人：KIHLBERG JAN; LARSSON ANDREAS; SVENSSON ANETTE; FEX TOMAS; HULTGREN SCOTT J; PINKNER JERRY
权利人:UNIV WASHINGTON; KIHLBERG JAN; LARSSON ANDREAS; SVENSSON ANETTE; FEX TOMAS; HULTGREN SCOTT J; PINKNER JERRY
摘要:Many Gram-negative pathogens assemble adhesive structures on their surfaces that allow them to colonize host tissues and cause disease. Novel compositions which inhibit or prevent the formation of a pilus chaperone-subunit complex are disclosed. Interfering with the function of the pili chaperone negatively affects the chaperone/usher pathway which is one molecular mechanism by which Gram-negative bacteria assemble adhesive pili structures and thus prevent or inhibit pilus assembly. Also provided are methods for the treatment or prevention of diseases caused by tissue-adhering pilus-forming bacteria by inhibiting the function of pilus chaperones. Also provided are pharmaceutical preparations capable of inhibiting or preventing the formation of a pilus chaperone-subunit complex. Also provided are methods of synthesizing the N-substituted amino acid compounds and compounds useful for the synthesis thereof. In particular, novel fluorinated linker compounds and methods of synthesis are provided. Methods for using the fluorinated linker compounds in methods of solid-phase synthesis of the N-substituted amino acid compounds are also disclosed.

专利号:US-6639023-B1
优先权日:1998-06-24
标题:Fluorophenyl resin compounds
发明人：SALVINO JOSEPH M; GRONEBERG ROBERT D; AIREY JOHN E; POLI GREGORY B; MCGEEHAN GERARD M; LABAUDINIERE RICHARD F; CLERC FRANCOIS-FREDERIC; BEZARD DANIEL NOEL ANDRE
权利人:AVENTIS PHARMA INC
摘要:This invention is directed to a fluorophenyl resin compound, to methods of its preparation; and to its use in the solid phase synthesis of amides, peptides, hydroxamic acids, amines, urethanes, carbonates carbamates, sulfonamides and α-substituted carbonyl compounds.

专利号:CN-1754899-A
优先权日:1998-06-24
标题:Solid phase synthesis of aldehydes, ketones, oximes, amines, hydroxamic acids and α, β-unsaturated carboxylic acids and aldehyde compounds

专利号:CN-100360580-C
优先权日:1998-06-24
标题 :Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha, beta-unsaturated carboxylic acid and aldehyde compounds

专利号:CN-1769318-A
优先权日:1998-06-24
标题 :Solid phase synthesis of aldehydes, ketones, oximes, amines, hydroxamic acids and α, β-unsaturated carboxylic acids and aldehyde compounds

专利号:CN-1307553-A
优先权日:1998-06-24
标题 :Solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha, beta-unsaturated carboxylic acid and aldehyde compounds