CAS: 64125-60-6; (E)-3-Methoxy-4-(3-Methylbut-2-En-1-yl)-5-Styrylphenol

上下游产品

2-methyl-3-buten-2-ol 3-methoxy-5-[(E)-2-phenylvinyl]phenol (E)-2,4-dimethoxy-6-styrylbenzoic acid methyl ester benzaldehyde

📜Methyl 2,4-Dimethoxy-6-[(E)-Styryl]Benzoate置于四(三苯基膦)钯,溴,三氯化硼,Potassium Hydroxide体系中,用 甲醇,乙醇,二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,-78.0~110.0 °C,344.75 Kpa 条件下,反应 14.5H,反应生成 Longistylin C; 3-甲氧基-4-(3-甲基-2-丁烯基)-5-[(1E)-2-苯基乙烯基]苯酚
参考文献:通过下调宿主硫酸软骨素n-乙酰半乳糖胺基转移酶1设计和合成抗丙型肝炎病毒的大麻素类似物.
标题:通过下调宿主硫酸软骨素n-乙酰半乳糖胺基转移酶1设计和合成抗丙型肝炎病毒的大麻素类似物.
摘要:由于对直接作用抗病毒剂(daa)产生抗性,仍然需要开发具有独特作用机理(moa)的新抗hcv剂.在这项工作中,通过表型筛选,卡那宁(一种从卡贾努斯.卡扬l.分离出来的斯蒂尔苯成分)被鉴定为有效的hcv抑制剂(ec 50 = 3.17+/-0.75μm).密集的结构优化为结构与活动之间的关系提供了重要的见识.此外,Moa研究表明,卡因碱通过下调细胞蛋白硫酸软骨素n抑制hcv复制-乙酰半乳糖胺基转移酶1.与这种靶向宿主的机制一致,卡贾宁对耐药性和野生型hcv表现出相似的抑制活性,并通过批准的daa协同抑制hcv复制.综上所述,我们的研究不仅提出了将卡贾宁衍生物作为一类新型的抗hcv药物,而且还发现了一种有前途的抗hcv靶标,可以抗药性.
DOI:10.1021/acs.Jmedchem.6B01301

专利信息

专利号:US-9359298-B2
优先权日:2011-12-23
标题:Cajanine structure analogous compound, preparation method and use
发明人：LI ZHUORONG; JI XINGYUE; Xue situ; ZHENG GUANGHUI; LI YUHUAN; TAO PEIZHEN; JIANG JIANDONG
权利人:INST MED BIOTECHNOLOGY CAMS
摘要:Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided are pharmaceutical compositions containing the compounds as active ingredient, and uses thereof; the compounds of the present invention having the pharmacological activities such as anti-virus, anti-virus-infection, nerve protection, anti-metabolic-diseases and the like. Also provided is a chemical total synthesis preparation method of the natural products cajanine, cajanine A and cajanine C. The present invention lays a foundation for the in-depth study and development of the compounds as clinical drugs in the future.