CAS: 6100-60-3; 4-Methoxybenzene-1,3-Diol

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CAS号621-59-0 异香兰素； 3-羟基-4-甲氧... | CAS号1324054-65-0 4-(formyloxy)-2... | CAS号1083312-69-9 1,3-bis(ethoxym... | CAS号99179-72-3 (5-hydroxy-2-me... | CAS号19009-24-6 Ameisensaeure-3... | CAS号6383-02-4 2,4-bis(benzylo... | CAS号881-57-2 3-乙酰氧基-4-甲氧基苯甲醛 | CAS号121-33-5 香草醛 | CAS号881-68-5 乙酰香兰素 | CAS号18113-18-3 2,5-二甲氧基苯酚 | CAS号40957-83-3 黄豆黄素 | CAS号92-61-5 东莨菪内酯； 莨菪亭 | CAS号3374-03-6 2H-1-Benzopyran... | CAS号1481-93-2 4-二乙酰醇 | CAS号145523-70-2 6-hydroxy-1,7-d... | CAS号7298-21-7 1-(2,4-二羟基-5-甲氧苯基)乙酮 | CAS号91401-25-1 acetic acid,4-m... | CAS号51061-83-7 2,4-二羟基-5-甲氧基苯甲醛

📜异香兰素置于magnesium Bis(Monoperoxyphthalate)Hexahydrate体系中,用 甲醇,水 作为反应溶剂,化学反应 24.0H,以79%的收率获得产物4-甲氧基间苯二酚
参考文献:阿尔特努伊醇结构与全合成的修订
标题:阿尔特努伊醇结构与全合成的修订
摘要:描述了所报道的阿替尼醇结构的全合成.合成化合物和天然产物的 1H NMR 谱的比较表明最初提出的结构不正确.因此,合成了两种结构异构体.其中一种化合物的光谱--一种最初被提议为交替烯醇结构的结构--与天然产物的光谱完美匹配.因此,以间苯二酚和原儿茶醛为起始原料,以 10 步和 23% 的产率实现了阿替尼醇的全合成,其中最长的线性序列由 6 步组成.关键步骤是伴随内酯环形成的 Suzuki 偶联.交替性与交替性是否相同尚不能确定.
DOI:10.1002/ejoc.201200506

专利信息

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:WO-03018819-A1
优先权日:2001-08-31
标题:Method for obtaining transformed corn plants with improved properties of digestibility, resulting corn plants and uses
发明人：PICHON MAGALIE; BECKERT MICHEL; NADAUD ISABELLE; GOFFNER DEBORAH
权利人:GENOPLANTE VALOR; PICHON MAGALIE; BECKERT MICHEL; NADAUD ISABELLE; GOFFNER DEBORAH
摘要:The invention concerns the use of a polynucleotide modulating the synthesis of COMT methyltransferase of corn encoded by the nucleotide sequence SEQ ID No. 1, in a method for obtaining corn plants with improved properties of digestibility having a modified ratio between the S and G units of lignin and having a modified lignin content which remains compatible with the normal development of the plant. The invention is useful for improving digestibility of corn.

专利号:US-7723498-B2
优先权日:2004-06-04
标题:Directed evolution of recombinant monooxygenase nucleic acids and related polypeptides and methods of use
发明人：WOOD THOMAS K; VARDAR GONUL
权利人:UNIV CONNECTICUT
摘要:The present invention relates to novel monooxygenase nucleic acids and polypeptides created using mutagenesis, DNA shuffling, or both, in a single iteration or multiple iterations, and methods for their creation and use. The monooxygenase enzymes of the present disclosure have particular utility as biocatalysts in industrial chemical redox reactions, such as the oxidation of aromatic hydrocarbons, for example, toluene, benzene, or nitrobenzene, into industrially desirable products. The systems and processes of the present invention are especially useful for the coupled synthesis and recovery of catechols, methylcatechols, resorcinols, methylresorcinols, hydroquinones, methylhydroquinones, hydroxybenzenes, cresols, nitrobenzenes, and nitrohydroxyquinones.

专利号:US-6610908-B1
优先权日:1996-07-19
标 题 :Manipulation of lignin composition in plants using a tissue-specific promoter
发明人：CHAPPLE CLINTON C S
权利人:PURDUE RESEARCH FOUNDATION
摘要:The present invention relates to methods and materials in the field of molecular biology, the manipulation of the phenylpropanoid pathway and the regulation of proteins synthesis through plant genetic engineering. More particularly, the invention relates to the introduction of a foreign nucleotide sequence into a plant genome, wherein the introduction of the nucleotide sequence effects an increase in the syringyl content of the plant's lignin. In one specific aspect, the invention relates to methods for modifying the plant lignin composition in a plant cell by the introduction there into of a foreign nucleotide sequence comprising at issue specific plant promoter sequence and a sequence encoding an active ferulate- 5 -hydroxylase (F 5 H) enzyme. Plant transformants harboring an inventive promoter-F 5 H construct demonstrate increased levels of syringyl monomer residues in their lignin, rendering the polymer more readily delignified and, thereby, rendering the plant more readily pulped or digested.

专利号:US-3651151-A
优先权日:1964-12-04
标 题 :Preparation of polyphenyl ether from dihydric phenols
发明人：BRIDGER ROBERT F; KINNEY ROBERT E; WILILAMS ALBERT L
权利人:MOBIL OIL CORP
摘要:DIHYDRIC PHENOIS CAN BE USED DIRECTLY IN THE ULLMANN ETHER SYNTHESIS BY USING A COPPER SALT CATALYST AND AN AMINE SOLVENT THAT DISSOLVES THE CATALYST BY FORMING COORDINATE COVALENT BONDS WITH COPPER IONS.

专利号:CN-105884733-B
优先权日:2016-05-17
标题 :A kind of stable isotope-labeled scopolamine and its synthesis method