CAS: 581-96-4; 2-(Naphthalen-2-yl)Acetic Acid

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7498-57-9 1485-07-0 2876-71-3

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CAS号201230-82-2 carbon monoxide | CAS号2506-41-4 2-(氯甲基)萘 | CAS号2876-70-2 2-萘乙酸乙酯 | CAS号1592-38-7 2-萘甲醇 | CAS号77495-23-9 2,2,2-trichloro... | CAS号939-26-4 2-(溴甲基)萘 | CAS号124-38-9 二氧化碳 | CAS号35480-23-0 2-(乙酰氧基甲基)萘 | CAS号7498-57-9 2-萘乙腈 | CAS号37859-25-9 2-(2-萘基)乙酰氯 | CAS号147702-15-6 S-2,2'-二苯基-3,3'... | CAS号19029-00-6 2-naphthalen-2-... | CAS号2086-62-6 2-(2-溴乙基)萘 | CAS号2086-65-9 N-甲基-2-萘-2-基-乙酰胺 | CAS号21969-45-9 1,2-Bis(2-napht... | CAS号91-57-6 2-甲基萘 | CAS号827-54-3 2-乙烯基萘 | CAS号66-99-9 2-萘甲醛 | CAS号2876-69-9 propyl 2-naphth...

2-甲基萘置于盐酸,N-溴代丁二酰亚胺(Nbs),Sodium Carbonate,过氧化苯甲酰体系中,用 四氯化碳,乙醇,水 作为反应溶剂,化学反应 21.0H,反应生成 2-萘乙酸
参考文献:N-酰氧基-N-烷氧基酰胺的 致突变性,作为dna嵌入的指示剂第1部分:萘作为dna嵌入剂的证据†
标题:N-酰氧基-N-烷氧基酰胺的 致突变性,作为dna嵌入的指示剂第1部分:萘作为dna嵌入剂的证据†
摘要:N-酰氧基-N-烷氧基酰胺是鼠伤寒沙门氏菌ta100中的直接作用诱变剂,对log P具有线性依赖性,在log P 0 = 6.4时最大.已证明在三个侧链的任何一个上带有萘基且log P 0 <6.4的八种n-酰氧基-N-烷氧基酰胺(2-9) 对鼠伤寒沙门氏菌ta100的致突变性均比50个诱变剂均匀得多.没有萘.2-9的活动增强可能是由于萘与细菌dna的插入结合,因为ta98是鼠伤寒沙门氏菌的移码菌株,也被插入剂修饰,在ta98中也有许多活性.带有萘的诱变剂的dna损伤特征证实了掺入萘后与dna的反应性增强,并且与不含萘的诱变剂相比具有不同的结合方式.该效果与萘是否连接至供电子的烷基或吸电子的酰基,烷基系链长度或(在6和7的情况下)萘的连接点无关.已为所有58个同类物构建了新的定量结构活性关系,其中包括对数 P和指标变量,I,对于萘的存在(i = 1)或不存在(i = 0),从中可以量化出萘的活性增强作用在三个和四个log
DOI:10.1039/c6Ob00162A

专利信息

专利号:US-11161827-B2
优先权日:2019-04-05
标 题 :Catalytic systems for stereoselective synthesis of chiral amines by enantiodivergent radical C—H amination
发明人：Zhang xiao-xiang; Lang kai
权利人:TRUSTEES BOSTON COLLEGE; THE TRUSTEES OF BOSTON COLLEGE
摘要:In one aspect, the disclosure relates to a mode of asymmetric induction in radical processes based on sequential combination of enantiodifferentiative H-atom abstraction and stereoretentive radical substitution. Also disclosed is an asymmetric system for stereoselective synthesis of strained 5-membered cyclic sulfamides via radical 1,5-C—H amination of sulfamoyl azides. The disclosed metalloradical system can control the degree and sense of asymmetric induction in the catalytic radical C—H amination in a systematic manner. The disclosed system is applicable to a broad scope of substrates with different types of C(sp 3 )—H bonds and exhibits reactivity and selectivity, providing access to both enantiomers of useful 5-membered cyclic sulfamides in a highly enantioenriched form. Also disclosed are catalysts useful in these processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-2003083352-A1
优先权日:2000-07-31
标 题 :Synthesis of imidazole intermediates
发明人：HELAL CHRISTOPHER J
权利人:PFIZER
摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.

专利号:US-6245937-B1
优先权日:1996-11-29
标题 :Liquid phase parallel synthesis of chemical libraries
发明人：CHENG SOAN; SAUNDERS JOHN
权利人:DUPONT PHARMACEUTICALS RES LAB
摘要:This invention features methods of biphasic synthesis for synthesizing combinatorial libraries and combinatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this invention.

专利号:US-9181292-B2
优先权日:2011-01-05
标题 :Methods for preparation of glycosphingolipids and uses thereof
发明人：LIANG PI-HUI
权利人:LIANG PI-HUI
摘要:Methods for synthesis and preparation of alpha-glycosphingolipids are provided. Methods for synthesis of α-galactosyl ceramide, and pharmaceutically active analogs and variants thereof are provided. Novel alpha-glycosphingolipids are provided, wherein the compounds are immunogenic compounds which serve as ligands for NKT (natural killer T) cells.

专利号:US-7846714-B2
优先权日:1998-09-17
标 题 :Synthesis of chemical tags
发明人：SARAF RAVI F
权利人:IBM
摘要:A method for forming a biological chemical tag. At least one double stranded DNA molecule is provided. At least a portion of the at least one double stranded DNA molecule is denatured. At least one chemical moiety that prohibits recrystallization of the at least one denatured portion to which the at least one chemical moiety is attached is attached to at least one nucleotide in the at least one denatured portion of the at least one double stranded DNA molecule.

专利号:EP-0946499-B1
优先权日:1996-11-22
标 题 :N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：WU JING; TUNG JAY S; NISSEN JEFFREY S; MABRY THOMAS E; LATIMER LEE H; EID CLARK NORMAN; AUDIA JAMES E
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions. Said compounds are represented by formula (I), wherein R<1> is selected from the group consisting of: a) alkyl, alkenyl, alkaryl, alkcycloalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocyclic; b) a substituted phenyl group of formula (II), wherein R is alkylene of from 1 to 8 carbon atoms, m is an integer equal to 0 or 1, and c) 1- or 2-naphthyl substituted at the 5, 6, 7 and/or 8 positions, R<2> is selected from the group consisting of hydrogen, alkyl of from 1 to 4 carbon atoms, alkylalkoxy of from 1 to 4 carbon atoms, alkylthioalkoxy of from 1 to 4 carbon atoms; and R<3> and R<3'> are independently selected from the group consisting of: (a) hydrogen, (b) alkyl, (c) -(R<7>)n(W)p, wherein R<7> is an alkylene group, W is selected from the group consisting of (i) formula (A); (ii) heteroaryl; and (iii) N-heterocyclic, and n is an integer equal to 0 or 1, and p is an integer equal to 1 to 3; (d) -CH( phi )CH2C(O)O-Q where Q is selected from the group consisting of alkyl, aryl, heteroaryl and heterocyclic; X' is hydrogen, hydroxy or fluoro; X'' is hydrogen, hydroxy or fluoro, or X' and X'' together form an oxo group, Z is selected from the group consisting of a bond covalently linking R<1> to -CX'X''-, oxygen and sulfur.