CAS: 55739-58-7; 1,2-Bis((R)-(2-Methoxyphenyl)(Phenyl)Phosphino)Ethane

该化合物是一个手淫的双胞胎,广泛用于非对称氢化反应.它的硬性C2对称结构使得高对等选择性,特别是在合成药物和精细化学等光活化合物时. 螺旋形成稳定的复合体,与过渡金属如和形成,提高了催化效率和基底范围. (R, R) -灯泡因其可预见立体化学结果和各种反应条件下的稳健度而受到重视. 它在生产高对应性过剩(ee)方面的效力使得它成为工业和学术应用的首选,需要精确的手力控制. 绳索的可靠性和记录良好的性能凸显了它在非对称催化中的重要性.

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MSDS等安全信息

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上下游产品

(R,R)-1,2-Ethandiylbis-(o-methoxyphenyl)-phenylphosphinoxid p)-(2-methoxyphenyl)methylphenylphosphine oxide(Rp)-(2-methoxyphenyl)methylphenylphosphine oxide P,RP)-1,2-bis[(o-anisyl)(phenyl)phosphino]ethane(RP,RP)-1,2-bis[(o-anisyl)(phenyl)phosphino]ethane (1R,1R')-(-)-1,1'-(1,2-ethanediyl)bis[1-(2-methoxyphenyl)-1-phenyl]phosphine oxide N-(cyclohex-2-enyl)pyrrolidine 2(DIPAMP)2(μ2-Cl)2][Rh2(DIPAMP)2(μ2-Cl)2] [Rh(DIPAMP)(cod)]+ P,RP)-1,2-bis[(o-hydroxyphenyl)(phenyl)phosphino]ethane(RP,RP)-1,2-bis[(o-hydroxyphenyl)(phenyl)phosphino]ethane

合成工艺路线路线简述

  • 99396-68-6 = 55739-58-7 + 97858-62-3
    反应条件:1.1 Reagents: Butyllithium Catalysts: Cuprous Chloride Solvents: Tetrahydrofuran; -20 °C; -20 °C -> Rt2.1 Reagents: (+)-Dibenzoyltartaric Acid Solvents: Methanol; Rt -> Reflux3.1 Reagents: Triethylamine,Trichlorosilane Solvents: Toluene; Rt -> Reflux3.2 Reagents: Sodium Hydroxide Solvents: Water
    标题:Method For Preparing Chiral 1,2-Bis [(2-Methoxyphenyl)Phenylphosphino]Ethane
    参考文献:China]

    55739-59-8 = 55739-58-7 + 97858-62-3
    反应条件:1.1 Reagents: Triethylamine,Trichlorosilane Solvents: Toluene; 10 H,100 °C1.2 Solvents: Water1.1 Reagents: Triethylamine,Trichlorosilane Solvents: Toluene; Rt -> Reflux1.2 Reagents: Sodium Hydroxide Solvents: Water
    标题:Preparation Method Of Chiral 1,2-Bis((R)-(2-Methoxyphenyl)(Phenyl)Phosphino)Ethanemethod For Preparing Chiral 1,2-Bis [(2-Methoxyphenyl)Phenylphosphino]Ethane
    参考文献:China]

    63589-61-7 = 55739-58-7 + 97858-62-3 [标题:Reaction Conditions
    标题:Comparative Hplc Enantioseparation Of Thirty-Six Aromatic Compounds On Four Columns Of The Lux Series: Impact Of Substituents,Shapes And Electronic Properties
    作者:Peluso,Paola; Et Al
    参考文献:Chirality 日期:2013 卷标:25(11) 页码:709-718]

    74713-67-0 = 55739-58-7 + 97858-62-3
    反应条件:1.1 Reagents: (+)-Dibenzoyltartaric Acid Solvents: Methanol,Dichloromethane; Rt; 12 H,40 °C1.2 Reagents: Sodium Hydroxide Solvents: Dichloromethane,Water; 40 °C2.1 Reagents: Triethylamine,Trichlorosilane Solvents: Toluene; 10 H,100 °C2.2 Solvents: Water1.1 Reagents: (+)-Dibenzoyltartaric Acid Solvents: Methanol; Rt -> Reflux2.1 Reagents: Triethylamine,Trichlorosilane Solvents: Toluene; Rt -> Reflux2.2 Reagents: Sodium Hydroxide Solvents: Water
    标题:Preparation Method Of Chiral 1,2-Bis((R)-(2-Methoxyphenyl)(Phenyl)Phosphino)Ethanemethod For Preparing Chiral 1,2-Bis [(2-Methoxyphenyl)Phenylphosphino]Ethane
    参考文献:China]

    106-93-4 + 107541-67-3 = 55739-58-7 + 97858-62-3
    反应条件:1.1 Reagents: Lithium Solvents: Tetrahydrofuran; 10 H,50 °C; 50 °C -> 0 °C1.2 0 °C1.3 Reagents: Water2.1 Reagents: (+)-Dibenzoyltartaric Acid Solvents: Methanol,Dichloromethane; Rt; 12 H,40 °C2.2 Reagents: Sodium Hydroxide Solvents: Dichloromethane,Water; 40 °C3.1 Reagents: Triethylamine,Trichlorosilane Solvents: Toluene; 10 H,100 °C3.2 Solvents: Water
    标题:Preparation Method Of Chiral 1,2-Bis((R)-(2-Methoxyphenyl)(Phenyl)Phosphino)Ethane
    参考文献:China
📜1,2-Ethanediylbis[(O-Anisylphenyl)Phenylphosphane Borane]置于碳酸氢钠,Tetrafluoroboric Acid Dimethyl Ether Complex体系中,化学反应生成 1,2-乙烷二基二[(2-甲氧基苯基)(苯基)膦]
参考文献:合成含有手性主链的富电子双膦的有效方法
标题:合成含有手性主链的富电子双膦的有效方法
摘要:描述了合成高手性双膦的一种非常实用的方法.该方法需要高手性二甲苯磺酸酯与适当的二烷基膦-硼烷阴离子进行顺序反应,然后由hbf 4 .ome 2介导的bh 3分解.
DOI:10.1016/s0040-4039(00)78531-5

海关参考信息

专利信息


专利号:US-4727146-A
优先权日:1980-07-03
标题 :Synthesis of chiral 1-benzyl-1,2,3,4-tetra-hydroisoquinolines by asymmetric reduction
发明人：RICE KENNER C
权利人:US HEALTH
摘要:In a short total synthesis of morphinan compounds, derivatives of 1-benzyl-1,2,3,4-tetrahydroisoquinoline are produced. Certain of these compounds, although highly aromatic and functionalized, can be optically resolved. The optically active enantiomers can serve as important intermediates for both natural and unnatural opioids. As a special function of this invention, certain of the derivatives, namely 4'-6' and 7'-9', may be hydrogenated to 1'-3' derivative by asymmetric reduction either of the catalytic or chemical type.

专利号:US-12378196-B2
优先权日:2018-12-11
标 题 :Synthesis of (S)-6-hydroxytryptophan and derivatives thereof
发明人：SIMON WERNER; WERNER-SIMON SUSANNE; MüLLER CHRISTOPH
权利人:HEIDELBERG PHARMA RES GMBH
摘要:The present invention relates to novel methods and compounds for synthesizing amanitin derivatives. The invention in particular relates to methods for synthesizing (S)-6-hydroxy-tryptophan derivatives which can be used as building blocks for synthesizing amanitin derivatives or amatoxin drug conjugates. The invention further relates to intermediate compounds of said synthesis pathways for use in amanitin derivative and amatoxin drug conjugate synthesis, and to the use of particular catalysts suited for mediating said synthesis pathways.

专利号:US-8729306-B2
优先权日:2010-02-05
标 题:Process for the preparation of nitrogen substituted aminotetralins derivatives
发明人：VASSELIN DAVID; CARLY NICOLAS; ATES CELAL
权利人:VASSELIN DAVID; CARLY NICOLAS; ATES CELAL; UCB PHARMA GMBH
摘要:The present invention provides an alternative synthesis of N-substituted aminotetralines which synthesis comprises catalytic asymmetric hydrogenation of compounds of general formula (A).

专利号:WO-2010048138-A1
优先权日:2008-10-21
标 题 :Synthesis of intermediates useful for the production of certain cgrp inhibitors and intermediates used in such synthesis
发明人：HADDAD NIZAR; KRISHNAMURTHY DHILEEPKUMAR; REEVES DIANA C; SENANAYAKE CHRIS H; TANG WENJUN; YEE NATHAN K
权利人:BOEHRINGER INGELHEIM INT; HADDAD NIZAR; KRISHNAMURTHY DHILEEPKUMAR; REEVES DIANA C; SENANAYAKE CHRIS H; TANG WENJUN; YEE NATHAN K
摘要:A method for making the compound of the formula (I), (IV), (VI), (VII) and (VIII), wherein R 1 is C -1-5 -alkyl, C(O)-O benzyl, C(O)-O- tert .butyl or benzyl; and R 2 is C 1 -C 6 alkyl.

专利号:US-2023220001-A1
优先权日:2020-06-09
标 题:Method for synthesis of thioether-containing peptides
发明人：GRUSS HENDRIK; LUTZ CHRISTIAN; SÃœSSMUTH RODERICH; Yao guiyang; KNITTEL CAROLINE; KOSOL SIMONE; MAINZ ANDI
权利人:HEIDELBERG PHARMA RES GMBH
摘要:The present invention relates to a method of formation of a sulphur bridge between tryptophan and cysteine in solid phase peptide synthesis under iodine treatment. The invention also relates to the resulting compounds of the method and their respective use.

专利号:US-6380416-B2
优先权日:1997-06-13
标题:Asymmetric synthesis catalyzed by transition metal complexes with rigid chiral ligands
发明人：ZHANG XUMU
权利人:PENN STATE RES FOUND
摘要:This invention is to develop novel transition metal catalysts for the practical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity.

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摘要:Fan, Y. C.; Kwon, O., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 766.
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