专利号:US-2021220331-A1 优先权日:2016-05-03 标题:Inhibitors of ires-mediated protein synthesis 发明人:GERA JOSEPH F; LICHTENSTEIN ALAN; JUNG MICHAEL E; LEE JIHYE; HOLMES BRENT; BENAVIDES-SERRATO ANGELICA 权利人:UNIV CALIFORNIA; THE UNITED STATE GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS 摘要:This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors.
专利号:US-6465693-B2 优先权日:1998-02-26 标 题 :Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates 发明人:BUCHWALD STEPHEN L; WAGAW SEBLE; GEIS O 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.
专利号:EP-1058678-B1 优先权日:1998-02-26 标 题:Metal-catalyzed arylations and vinylations of hydrazines, hydrazones, hydroxylamines and oximes 发明人:BUCHWALD STEPHEN L; WAGAW SEBLE; GEIS OLIVER 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.
专利号:CN-117285453-A 优先权日:2023-10-10 标 题 :A method for catalyzing the synthesis of N-substituted-3-methyl indole compounds using nitrogen heterocyclic carbene oxazoline palladium compounds
专利号:WO-2017192665-A1 优先权日:2016-05-03 标题 :Inhibitors of ires-mediated protein synthesis
专利号:EP-3452447-A1 优先权日:2016-05-03 标题:Inhibitors of ires-mediated protein synthesis
[参考文献]: H Nikaido, Et Al. Oxidation Of 1,1-Diphenylhydrazine To N-Nitrosodiphenylamine By Superoxide Radical In The Eye. Jpn J Ophthalmol. 1992;36(1):103-7. [参考文献]: K Tatsumi, Et Al. Reduction Of N-Nitrosodiphenylamine To The Corresponding Hydrazine By Guinea Pig Liver Preparations. Chem Pharm Bull (Tokyo). 1982 Oct;30(10):3842-5.
合成参考文献
摘要:Merck Index - O'Neil MJ, Heckelman PE, Dobbelaar PH, Roman KJ (eds). The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals, 15th Ed. Cambridge, UK: The Royal Society of Chemistry, 2013.