CAS: 4836-13-9; N-(1-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-2-Oxo-1,2-Dihydropyrimidin-4-yl)Benzamide

相似化合物

51549-36-1 13089-48-0 52571-45-6

上下游产品

2'-deoxycytidine monohydr°Chloride benzoyl chloride 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 4-benzoylcytidineN4-benzoylcytidine4-N-benzoyl-5'-O-pixyl-2'-deoxycytidine 4-benzoyl-2'-deoxycytidine5'-O-dimethoxytrityl-N4-benzoyl-2'-deoxycytidine N-(1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide 4-benzoyl-O3',O5'-bis(tert-butyldimethylsilyl)-2'-deoxycytidineN4-benzoyl-O3',O5'-bis(tert-butyldimethylsilyl)-2'-deoxycytidine

2'-脱氧胞苷盐酸盐置于sodium Hydroxide体系中,用 四氢呋喃,吡啶,甲醇,水 作为反应溶剂,化学反应 1.17H,反应生成 N-苯甲酰-2'-脱氧胞苷
参考文献:四个十氧代核糖核苷酸的简化液相制备及其初步光谱表征
标题:四个十氧代核糖核苷酸的简化液相制备及其初步光谱表征
摘要:Daptpaptpaptpaptpapt,Daptpaptpcpgpaptpapt和dapapapapapapapapaptptptly化学合成了四个自互补的十氧杂核糖核苷酸daptpaptpaptpaptpapt,Daptpaptpcpgpcpaptpaptply.努力集中于使过程尽可能简单,同时在该过程的每个步骤中获得高纯度的产品.根据以下方案,从3'-末端以3'-O-苯甲酰化的单体开始精加工十聚体:单体+单体二聚体+二聚体四聚体+二聚六聚体+四聚体十聚体.中间体和完全封闭的十聚体的纯度通过色谱法和300Mhz 1 Hn M R.光谱法进行监测.解封闭的十氧杂核糖核苷酸的特征在于它们的uv,Cd和1 HNMR.光谱.
DOI:10.1002/hlca.19820650803

专利信息

专利号:WO-2024082545-A1
优先权日:2022-10-21
标 题:Method for enzymatic synthesis of nucleoside containing protecting group, and composition
发明人：HONG HAO; JAMES GAGE; XIAO YI; ZHANG NA; JIAO XUECHENG; LI MINGJI; LI RUI; DING SHIMAO
权利人:ASYMCHEM LIFE SCIENCE TIANJIN CO LTD
摘要:The present invention provides a method for enzymatic synthesis of a nucleoside containing a protecting group, and a composition. The method comprises: using pyrimidine nucleoside phosphorylase or uracil nucleoside phosphorylase and purine nucleoside phosphorylase to catalyze a substrate to synthesize a nucleoside containing a protecting group, wherein the substrate comprises a substrate nucleoside, a substrate base and a substrate phosphate, and the substrate base contains a protecting group; the pyrimidine nucleoside phosphorylase comprises a protein which has more than 80% homology with a protein PyNP shown in SEQ ID NO: 1; the uracil nucleoside phosphorylase comprises a protein which has more than 80% homology with a protein UP shown in SEQ ID NO: 2; and the purine nucleoside phosphorylase comprises a protein which has more than 80% homology with a protein PNP shown in SEQ ID NO: 3, 7 or 8. The present invention can solve the problem in the prior art that there is no biosynthesis method to produce a nucleoside containing a protecting group, and is suitable for the field of enzyme catalysis.

专利号:US-5859234-A
优先权日:1992-06-03
标 题:2'-O-methyl cytidine monomer useful in oligonucleotide synthesis
发明人：VAGHEFI MORTEZA M
权利人:GENTA INC
摘要:Methods of preparing N 4 -alkanoyl, aroyl and aralkanoyl 2'-O-methylcytidine derivatives are provided. Also provided are cytidine derivatives and nucleoside monomers comprising these cytidine derivatives which are useful in the synthesis of Oligomers, including oligonucleotides and methylphosphonate Oligomers.

专利号:WO-8203079-A1
优先权日:1981-03-10
标题 :Rapid solid phase synthesis of oligonucleotides using phosphorus oxychloride activation
发明人：VERLANDER MICHAEL S; FULLER WILLIAM DEAN; GOODMAN MURRAY
权利人:BIORESEARCH INC
摘要:Method for synthesizing oligonucleotides comprising the steps of filling a flow reactor with a supported nucleoside consisting of a first nucleoside attached in position (5 ') to an insoluble solid support, activating this support nucleoside by a treatment with phosphorus oxychloride in the presence of a basic catalyst in order to form a 3'-dichlorophosphoryl group on the first nucleoside, to couple a second analogous or different nucleoside, unprotected at positions 3 'and 5', to the first nucleoside by condensation with the dichlorophosphoryl group and to repeat this activation and coupling step until the desired oligonucleotide sequence is obtained. The oligonucleotide can then be cleaved from the support and purified, if necessary.

专利号:WO-0127126-A1
优先权日:1999-10-14
标题 :Process for the preparation of phosphorothioate triesters and oligonucleotides
发明人：DOUGLAS MARK EDWARD; SCOTT KEVIN GERARD
权利人:AVECIA LTD; DOUGLAS MARK EDWARD; SCOTT KEVIN GERARD
摘要:A process for the synthesis of a phosphorothioate triester is provided. The process comprises the reaction, in the presence of a coupling agent, of an H-phosphonate with a substrate comprising a free hydroxy group and bonded to a solid support, thereby forming a supported H-phosphonate diester, and subjecting the H-phosphonate diester to sulphur transfer with a sulphur transfer agent.

专利号:US-6677120-B2
优先权日:2001-03-30
标 题 :Building blocks for the solution phase synthesis of oligonucleotides
发明人：SANGHVI YOGESH S; GOTOR VICENTE; FERRERO MIGUEL; FERNANDEZ SUSANA; GARCIA JAVIER
权利人:ISIS PHARMACEUTICALS INC
摘要:The present invention is directed to methods for the preparation of 3′-O and 5′-O-levulinyl nucleosides from common precursors using an enzymatic approach.

专利号:US-4500707-A
优先权日:1980-02-29
标题:Nucleosides useful in the preparation of polynucleotides
发明人：CARUTHERS MARVIN H; MATTEUCCI MARK D
权利人:UNIVERSITY PATENTS INC
摘要:New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic acids (DNA).