CAS: 446-48-0; 1-(Bromomethyl)-2-Fluorobenzene

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CAS号95-52-3 邻氟甲苯 | CAS号446-52-6 邻氟苯甲醛 | CAS号446-51-5 2-氟苄醇 | CAS号10035-10-6 氢溴酸 | CAS号71-43-2 苯 | CAS号506-68-3 溴化氰 | CAS号368-06-9 (2-fluoro-benzy... | CAS号401-35-4 N-Benzyl-2-fluo... | CAS号7726-95-6 溴素 | CAS号326-62-5 邻氟氰苄 | CAS号346640-52-6 1-(2-氟苄基)-1H-吲哚... | CAS号3794-15-8 1-苄基-2-1-苄基-2-氟苯氟苯 | CAS号517920-60-4 2-氟苄基硼酸频哪醇酯 | CAS号446-52-6 邻氟苯甲醛 | CAS号446-51-5 2-氟苄醇 | CAS号89-99-6 邻氟苄胺 | CAS号399-30-4 N-甲基-2-氟苄胺 | CAS号192997-17-4 1-(2-Fluoro-ben... | CAS号95-52-3 邻氟甲苯

2-氟苄醇置于三溴化磷体系中,用 乙醚 作为反应溶剂,化学反应 0.5H,反应生成 2-氟溴苄
参考文献:新型间乙酰氨基酚嵌入 [1,2,3]-三唑衍生物的合成,对接和生物活性
标题:新型间乙酰氨基酚嵌入 [1,2,3]-三唑衍生物的合成,对接和生物活性
摘要:Erα控制乳腺癌的乳腺组织发育和进展.在我们寻找靶向雌激素受体 α 配体结合域的新型化合物时,我们确定了"n-(3-((1H-1,2,3-Triazol-4-yl)Methoxy)Phenyl)乙酰胺"衍生物作为先导化合物. 对接研究表明,当对接至 1Xp6 时,间乙酰氨基酚衍生物的对接得分非常好.已经合成,表征和评估了一系列间乙酰氨基酚衍生物的细胞毒性,抗细菌和抗氧化活性.在测试的 12 种杂化化合物中," 7A,7G,7H和7I"衍生物显示出非常好的细胞毒性,对 Mcf-7 细胞系的ic 50值为 <22 µg/ml.化合物" 7A,7D,7E,7F,7H,7I,7J,7K和7L"显示出出色的抗氧化活性,Ic 50值 < 30 µm,而化合物" 7A,7B,7C,7D,7G,7J,7K和7L"显示中等抗菌活性,Mic 值 <300 µm.
DOI:10.1016/j.Molstruc.2021.130786

专利信息

专利号:US-7468375-B2
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人：DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; WANG HAI; YANG ANLE; YIN CHUNFENG; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:US-8329686-B2
优先权日:2006-08-29
标题:Isatin analogues and uses therefor
发明人：MACH ROBERT H; WELCH MICHAEL; CHU WENHUA; ROTHFUSS JUSTIN
权利人:MACH ROBERT H; WELCH MICHAEL; CHU WENHUA; ROTHFUSS JUSTIN; UNIV WASHINGTON
摘要:Novel isatin analogues, including isatin analogues comprising Michael Acceptors (IMAs) are disclosed. Further disclosed are methods of synthesis of the isatin analogues, and uses of the analogues, including inhibition of caspase-3 and caspase-7, and in vivo imaging of apoptosis by Positron emission tomography (PET) or Single Photon Emission Computed Tomography (SPECT).

专利号:WO-9323388-A1
优先权日:1992-05-20
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors

专利号:PL-240596-B1
优先权日:2018-12-06
标 题 :Synthesis of pyridin-2-yl-vinylpyridinyl (PvP) derivatives

专利号:US-6861523-B2
优先权日:2002-02-08
标 题 :1,3,5- trisubstituted-1,3,5-triazine-2,4,6-trione compounds and libraries
发明人：YU YONGPING; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:The solid-phase synthesis of individual 1,3-disubstituted and 1,3,5-trisubstituted-1,3,5-triazine-2,4,6-triones and libraries thereof from a resin is described. Reaction of resin-bound amino acids with isocyanates yields resin-bound ureas, which further react with chlorocarbonyl isocyanate to selectively afford the resin-bound 1,3-disubstituted-1,3,5-triazine-2,4,6-triones. Selective alkylation at the N-5 position of the resin-bound 1,3-disubstituted-1,3,5-triazine-2,4,6-triones produces a trisubstituted triazinetrione. The products are cleaved from their solid support and obtained in good yield and purity.

专利号:EP-0641333-A1
优先权日:1992-05-20
标 题:METHOD FOR PRODUCING INTERMEDIATES IN THE SYNTHESIS OF RETROVIRAL PROTEASE INHIBITORS.