CAS: 3934-84-7; 3,4-Dihydroxy-5-Methoxy-Benzoic Acid

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3-formyl-4-hydroxy-5-methoxybenzoic acid 3-amino-4-hydroxy-5-methoxy-benzoic acid methyl 3-methoxy-4,5-diphenylmethylenedioxybenzoate 3,4,5-trihydroxybenzoic acid methyl 3,4-dihydroxy-5-methoxybenzoate 3-meth°Cycatechol 5-methoxy-3,4-methylenedioxybenzoic acid 3,4-diacetoxy-5-methoxy-benzoic acid

📜没食子酸甲酯置于氢氧化钾,Potassium Carbonate,溶剂黄146体系中,用 甲醇,乙醚,丙酮 用作溶剂,化学反应 41.17H,反应生成3-O-甲基没食子酸
参考文献:没食子酸代谢物是人类摄入红茶的标志.
标题:没食子酸代谢物是人类摄入红茶的标志.
摘要:没食子酸是红茶的主要酚类成分之一.这项研究的目的是确定尿中没食子酸代谢物有可能用作红茶摄入的标志物.在初步研究中,发现3种红茶经过3小时后,通过气相色谱-质谱法评估的9种化合物尿液中的浓度增加.随后的研究采用了受控交叉设计,其中10名受试者随机顺序每天饮用5杯红茶或水达4周.在每个阶段结束时收集二十四小时尿液样本.在初始研究中确定的9种候选化合物中,与饮水时期相比,饮茶期间所有10位受试者的尿液中只有3种以较高的浓度存在.这些化合物被鉴定为4-O-甲基没食子酸,3-O-甲基没食子酸和3,4-O-二甲基没食子酸,都是没食子酸的甲基醚衍生物.建议这些化合物具有用作红茶摄入量标记的潜力.
Doi:10.1021/jf000089S

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:US-5569786-A
优先权日:1987-01-06
标 题 :Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated 'combretastatins'
发明人：PETTIT GEORGE R; SINGH SHEO B
权利人:UNIV ARIZONA
摘要:New antineoplastic substances have been isolated, structurally elucidated and synthesized having a general structural formula of: (I) or H or OCH3; or R1R2 is -OCH2O-; R3 is H or OH; and R4 is OH or OCH3. These substances have been denominated 'combretastatin A-1, -A-2, -A-3, -B-1, -B-2, -B-3 and -B-4'. preparation containing the substances and methods of treating a host inflicted with a neoplastic growth with the preparation is described.