CAS: 37859-24-8; 2-(4-Bromophenyl)Acetyl Chloride

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CAS号1878-68-8 对溴苯乙酸 | CAS号1197-55-3 对氨基苯乙酸 | CAS号7719-09-7 氧氯化硫 | CAS号106554-02-3 4-[2-(4-hydroxy... | CAS号41841-16-1 4-溴苯乙酸甲酯 | CAS号502685-91-8 5-(4-溴苄基)-4H-1,... | CAS号4133-35-1 6-溴-3,4-二氢-1H-2-萘酮 | CAS号295318-80-8 2-(4-bromopheny... | CAS号19078-72-9 Α-溴苯乙酰氯 | CAS号99070-18-5 2-(4-溴苯基)丁酸 | CAS号7713-76-0 2-(4-溴苯基)-N-甲基乙酰胺 | CAS号6186-22-7 4-溴苯基丙酮 | CAS号736991-39-2 4-(4-溴苯乙基)吗啉

📜4-溴苯乙酸甲酯置于草酰氯,N,N-二甲基甲酰胺,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,二氯甲烷,水 作为反应溶剂,化学反应 14.0H,反应生成 4-溴苯乙酰氯
参考文献:通过奎宁和奎尼丁的硼酸盐酯解析拱顶联芳基配体.
标题:通过奎宁和奎尼丁的硼酸盐酯解析拱顶联芳基配体.
摘要:考虑到(+)-和(-)-天冬氨酸成本的突然和无法解释的增长,已经开发了用于解决拱形联芳的替代方法.该方法涉及外消旋拱形联芳基配体与一当量的bh 3 .sme 2和一当量的奎宁或奎尼丁反应.由于溶解度不同,然后从所得非对映体硼酸盐的混合物中形成沉淀.在奎宁和(r的情况下,沉淀物的水解会释放(S)-配体(对于奎尼丁而言)-配体,其ee均> 99%.该方法已应用于16种不同的拱形联芳基配体,其中包括10种,其制备方法首次在此进行了描述.另外,已经证明了该方法结合可外消旋配体的非手性铜(II)配合物用于拱形联芳基配体的动态热力学拆分的原理证明.
DOI:10.1021/acs.Joc.0C00494

专利信息

专利号:US-5623068-A
优先权日:1994-03-07
标 题:Synthesis of DNA using substituted phenylacetyl-protected nucleotides
发明人：REDDY M PARAMESWARA; FAROOQUI FIRDOUS; HANNA NAEEM B
权利人:BECKMAN INSTRUMENTS INC
摘要:Deoxyribonucleotide and ribonucleotide derivatives of the general formula I I wherein R1 represents -CR'R''-Ar, in which Ar is substituted aryl (as hereinafter defined) and R' and R'' are independently selected from the group consisting of hydrogen and lower alkyl; one of -R2 and R3 is a hydroxyl-protecting group and the other is a group suitable for synthesis of polynucleotides or for attachment of the nucleotide to a solid support; R4 is selected from the group consisting of hydrogen, -OH and protected hydroxyl; and B represents a divalent radical corresponding to a purine or pyrimidine base. When synthesis is carried out using these derivatives, the deprotection procedure is reduced to an essentially instantaneous process. The derivatives have acceptable shelf life and are very stable to conventional DNA synthesis conditions. Particularly preferred are those compounds wherein Ar is mono- and dihalo-substituted phenyl.

专利号:US-5464762-A
优先权日:1994-06-24
标题:Asymmetric bioreduction of 6-bromo-2-tetralone to (s)-6-bromo-2 tetraol by trichosporon capitatum
发明人：CHARTRAIN MICHEL M; REDDY JAYANTHI; TSCHAEN DAVID M
权利人:MERCK & CO INC
摘要:Stereospecific (S)-6-bromo-2-tetraol is a key intermediate in the chemical synthesis of the chiral drug candidate, MK499, a ventricular arrythmias suppressant. The yeast strain Trichosporon capitatum (MY 1890) was employed for the bioconversion of 6-bromo-2-tetralone to the corresponding alcohol.

专利号:US-7479575-B2
优先权日:2003-10-13
标 题:Method for preparing para-phenyl alkynyl benzaldehydes
发明人：SWINNEN DOMINIQUE; POHIN DANIG
权利人:SERONO LAB
摘要:The present invention is related to a new synthesis for preparing para-phenyl alkynyl benzaldehyde of general formula (I). The compounds of formula (I) are useful building blocks, in particular in the synthesis of electrically conducting polymers. R is selected from the group consisting of C 1 -C 12 -alkyl, C 1 -C 12 -alkyl aryl, C 1 -C 12 -alkyl heteroaryl, C 2 -C 12 -alkenyl, C 2 C 12 -alkenyl aryl, C 2 -C 12 -alkenyl heteroaryl, C 2 -C 12 -alkynyl, C 2 -C 12 -alkynyl aryl, C 2 -C 12 -alkynyl heteroaryl, C 3 -C 8 -cycloalkylC 1 -C 12 -alkyl-C 3 -C 8 -cycloalkyl, C 1 -C 12 -alkoxy, aryl, heteroaryl, halides.

专利号:JP-H09510206-A
优先权日:1994-03-07
标 题 :Compositions and methods used in the synthesis of oligonucleotides

专利号:WO-9524413-A1
优先权日:1994-03-07
标 题 :Compositions and methods for use in the synthesis of oligonucleotides

专利号:WO-9965878-A1
优先权日:1998-06-18
标题 :Synthesis of benzo[f]quinolinones
发明人：HEATH PERRY CLARK
权利人:LILLY CO ELI; HEATH PERRY CLARK
摘要:A process for preparing intermediates and benzoquinolin-3-one pharmaceuticals, such pharmaceuticals are effective in treating conditions consequent on 5α-reductase.