CAS: 35453-19-1; 5-Amino-2,4,6-Triiodoisophthalic Acid

相似化合物

35453-19-1 51411-81-5 154921-11-6

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CAS号99-31-0 5-氨基间苯二甲酸 | CAS号37441-29-5 5-氨基-2,4,6-三碘异酞酰氯 | CAS号60166-93-0 碘帕醇 | CAS号76801-93-9 5-氨基-2,4,6-三碘-N... | CAS号148051-08-5 N,N'-双[2-(乙酰氧基)... | CAS号40976-89-4 2,4,6-triiodo-5...

5-硝基异酞酸置于一氯化碘体系中,化学反应 5.0H,反应生成 5-氨基-2,4,6-三碘间苯二甲酸
参考文献:一种碘帕醇的合成及其合成中间体的制备
标题:一种碘帕醇的合成及其合成中间体的制备
摘要:本发明涉及化工合成工艺技术领域,尤其是一种碘帕醇的合成及其合成中间体的制备,本发明制备工艺通过调整投料重量比例,优化反应条件,改善碘帕醇的合成路线,对化合物反应的条件要求更低,对反应的控制十分简单,在提高收率的同时大大提高了中间体产品的质量,从而碘帕醇在生产过程中工艺控制的难度,提高了碘帕醇的质量和合格率,此制备工艺各步骤操作方法简单,溶剂及工艺条件安全易行,实现了环保绿色生产,具有广阔的应用前景.

专利信息

专利号:US-5817861-A
优先权日:1996-03-29
标题 :Process for the preparation of an intermediate useful in the synthesis of iodinated contrast media
发明人：VILLA MARCO; NARDI ANTONIO; PAIOCCHI MAURIZIO
权利人:BRACCO INT BV
摘要:A process for the preparation of (S)-N,N'-bis 2-hydroxy-1-(hydroxymethyl)ethyl!-5-(2-acetoxy-propionylamino)-2,4,6-triiodo-isophthalamide, an intermediate useful for the synthesis of iopamidol, by reaction between L-5-(2-acetoxy-propionylamino)-2,4,6-triiiodoisophthaloyl dichloride and 2-amino-1 ,3-propanediol in N-methylpyrrolidone and in the presence of a base, is described.

专利号:US-9157156-B2
优先权日:2009-07-07
标题 :Process for the preparation of a iodinating agent
发明人：ANELLI PIER LUCIO; VISCARDI CARLO FELICE; DELOGU PIETRO; GOFFREDI FABRIZIO; NARDELLI ALFONSO; GIOVENZANA GIOVANNI BATTISTA
权利人:ANELLI PIER LUCIO; VISCARDI CARLO FELICE; DELOGU PIETRO; GOFFREDI FABRIZIO; NARDELLI ALFONSO; GIOVENZANA GIOVANNI BATTISTA; BRACCO IMAGING SPA
摘要:The present invention describes a process for the synthesis of a iodinating agent, being said iodinating agent iodine chloride (ICI.) In particular, the present invention relates to a process for the electrochemical preparation of ICI, as a useful iodinating agent in the preparation of iodinated organic compounds for use as contrast agents or their precursors in the synthesis of the same.

专利号:US-10836711-B2
优先权日:2017-02-10
标 题 :Method for the one-pot production of organo-iodinated compounds
发明人：PETTA MYRIAM; PELLINGHELLI STEPHAN
权利人:GUERBET SA
摘要:The present invention concerns a process for the preparation of organo-iodized compounds, as well as their preparation intermediates. More particularly, the present invention concerns a process for the preparation of organo-iodized compounds which can be used as preparation intermediates in the synthesis of iodized contrast agents.

专利号:US-5663432-A
优先权日:1995-05-18
标 题:Process for the preparation of 5-amino-2,4,6-Triiodoisophthalic acid dichloride by chlorination with thionyl chloride in the presence of a catalyst
发明人：VILLA MARCO; POZZOLI CLAUDIO; RUSSO LAURA; CASTALDI GRAZIANO
权利人:ZAMBON SPA
摘要:A process for the preparation of 5-amino-2,4,6-triiodoisophthalic acid dichloride by chlorination of 5-amino-2,4,6-triiodoisophthalic acid with thionyl chloride in the presence of a suitable solvent characterized in that the reaction is carried out in the presence of catalytic amounts of a tetraalkylammonium salt of formula R1R2R3R4NX (I) wherein X is halogen, mesylate or tosylate; R1, R2, R3 and R4, the same or different, are C1-C20 alkyl groups so that the total number of carbon atoms of the groups R1, R2, R3 and R4 is higher than 16. The 5-amino-2,4,6-triiodoisophthalic acid dichloride obtained according to the process of the present invention is useful as intermediate in the synthesis of iodinated contrast media.

专利号:US-11472767-B2
优先权日:2018-08-02
标 题 :Process for the monotopic preparation of intermediate organo-iodinated compounds for the synthesis of ioversol
发明人：STÉPHAN PELLINGHELLI; PETTA MYRIAM
权利人:GUERBET SA
摘要:A process for preparing an organo-iodinated compound, comprising the following steps:a) acylating 2,4,6-triiodo-5-aminoisophthalic acid of formula (A) below:to obtain an intermediate compound Ya;b) chlorinating the intermediate compound Ya to obtain an organo-iodinated intermediate compound Yb;c) amidating the organo-iodinated intermediate compound Yb to obtain an intermediate compound Yc; andd) deprotecting the intermediate compound Yc, the steps a), b), c) and d) being carried out without isolation of at least one intermediate compound chosen from Ya and Yc.

专利号:US-5849953-A
优先权日:1996-06-13
标 题:Process for the purification of an intermediate
发明人：DESANTIS NICOLA
权利人:FRUCTAMINE SPA
摘要:This invention refers to a new process for the synthesis of (S)-N,N'-bis (2-hydroxy-1-(hydroxymethyl)ethyl!-5- (2-hydroxy-1-oxopropyl!amino!-2,4,6-triiodo-1,3-benzendicarboxamide, of formula (III), ##STR1## starting from 5-amino-2,4,6-triiodo-1,3-benzendicarboxylic acid dichloride characterized by a new step of chromatographic purification through resins of (S)-5- 2-(acetyloxy)-1-oxopropyl!amino!-2,4,6-triiodo-1,3-benzendicarboxylic acid dichloride, which enables the direct conversion to the compound of formula (III), without preventive isolation.