CAS: 3006-60-8; (2S,3R,4R,5R,6R)-3-Acetamido-6-(Acetoxymethyl)Tetrahydro-2H-Pyran-2,4,5-Triyl Triacetate

上下游产品

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D-(+)-Galactosamine Hydrochloride置于吡啶体系中,用 乙酸酐 作为反应溶剂,化学反应 2.0H,以93%的收率获得产物beta-D-2-乙酰氨基-2-脱氧半乳糖 1,3,4,6-四乙酸酯
参考文献: Polynucleotide Constructs[fr] Constructions Polynucléotidiques
标题: Polynucleotide Constructs[fr] Constructions Polynucléotidiques
摘要:揭示了具有与携带一个或多个辅助基团的基团相连的多核苷酸构造.还披露了被糖类似物中断的多核苷酸构造,以及具有立体化学富集的磷酸硫酸酯的多核苷酸构造.这些多核苷酸构造可以作为杂交多核苷酸构造提供.还包括将多核苷酸构造传递给细胞的方法,以及通过将细胞与披露的多核苷酸构造或杂交多核苷酸构造接触来减少细胞中蛋白质表达的方法.

专利信息

专利号:US-10751419-B2
优先权日:2014-05-01
标题:Method for synthesis of reactive conjugate clusters
发明人：MIGAWA MICHAEL T; YU JINGHUA; WAN W BRAD; PATEL SAYTEN P; VASQUEZ GUILLERMO; KINBERGER GARTH A; PRAKASH THAZHA P; SETH PUNIT P; SWAYZE ERIC E
权利人:IONIS PHARMACEUTICALS INC
摘要:Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.

专利号:US-2019209694-A1
优先权日:2014-05-01
标 题 :Method for synthesis of reactive conjugate clusters

专利号:EP-3137115-B1
优先权日:2014-05-01
标题:Method for synthesis of reactive conjugate clusters

专利号:EP-4223315-A2
优先权日:2014-05-01
标 题:Method for synthesis of reactive conjugate clusters

专利号:US-2017043025-A1
优先权日:2014-05-01
标题:Method for synthesis of reactive conjugate clusters

专利号:US-10098959-B2
优先权日:2014-05-01
标 题 :Method for synthesis of reactive conjugate clusters