CAS: 295349-62-1; Tert-Butyl 2-Chloroisonicotinate

相似化合物

6313-54-8 75308-46-2 54453-93-9

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CAS号6313-54-8 2-氯异烟酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号36805-97-7 N,N-二甲基甲酰胺二叔丁基缩醛 | CAS号65287-34-5 2-氯吡啶-4-甲酰氯 | CAS号865-47-4 叔丁醇钾 | CAS号67098-46-8 tert-butyl N,N-... | CAS号295349-63-2 2-(4-吗啉基)-吡啶-4-羧酸叔丁酯 | CAS号887579-37-5 tert-butyl 2-cy...

📜2-氯吡啶-4-甲酰氯置于potassium Tert-Butylate体系中,用 四氢呋喃 用作溶剂,化学反应生成2-氯异烟酸叔丁酯
参考文献:Amide Derivatives
标题:Amide Derivatives
摘要:该发明涉及formula I的酰胺衍生物 其中x为ch或n;Y为ch或n;M为0-3;R1为羟基,卤素,三氟甲基,氰基,巯基,硝基,氨基,羧基和氨甲酰等基团;N为0-3;R2为羟基,卤素,三氟甲基,氰基,巯基,硝基,氨基,羧基和(1-6C)烷氧羰基等基团;R3为氢,卤素,(1-6C)烷基或(1-6C)烷氧基;Q为0-4;Q为芳基,芳氧基,芳基-(1-6C)烷氧基,芳基氨基,N-(1-6C)烷基-芳基氨基和芳基-(1-6C)烷基氨基等基团;或其药学上可接受的盐或体内可水解酯;它们的制备方法,含有它们的药物组合物以及它们在治疗由细胞因子介导的疾病或医疗状况中的用途.

专利信息

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:US-2008058528-A1
优先权日:2006-07-20
标题 :Synthesis of (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile

专利号:EP-2057145-B1
优先权日:2006-07-20
标 题:Synthesis of (2s,5r)-5-ethynyl-1-{n-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile

专利号:US-2016152600-A1
优先权日:2006-07-20
标题 :Synthesis of (2s,5r)-5-ethynyl-1-pyrrolidine-2-carbonitrile

专利号:CN-101516872-A
优先权日:2006-07-20
标 题 :(2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2 -Synthesis of forminonitrile

专利号:US-9260411-B2
优先权日:2006-07-20
标 题 :Synthesis of (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile
发明人：MCDERMOTT TODD S; WAGAW SEBLE H; ENGSTROM KENNETH M; GANDARILLA JORGE; KRUGER ALBERT; ROZEMA MICHAEL J; FICKES MICHAEL G; WITTENBERGER STEVEN J; BHAGAVATULA LAKSHMI; BORCHARDT THOMAS B
权利人:MCDERMOTT TODD S; WAGAW SEBLE H; ENGSTROM KENNETH M; GANDARILLA JORGE; KRUGER ALBERT; ROZEMA MICHAEL J; FICKES MICHAEL G; WITTENBERGER STEVEN J; BHAGAVATULA LAKSHMI; BORCHARDT THOMAS B; ABBVIE INC
摘要:A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, and intermediates used in the process are disclosed.