CAS: 247564-71-2; 2,3,6-Trifluorophenylboronic Acid

专利信息

专利号:WO-2014202765-A1
优先权日:2013-06-21
标题 :Preparation of chiral 1-methyl-2,3,4,5-1h-benzodiazepines via asymmetric reduction of alpha-substituted styrenes
发明人：STAVBER GAJ; GAZIC SMILOVIC IVANA; CLUZEAU JEROME; RICHTER FRANK
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides an asymmetric and economic synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine via novel intermediates applying an asymmetric enzymatic, biomimetic or catalytic reduction. The present invention also provides a novel green asymmetric catalytic reduction adapted for an aqueous medium to be applied in the synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine or novel intermediates.

专利号:WO-2014173928-A1
优先权日:2013-04-23
标题 :Novel synthetic process to 8-chloro-1-methyl-benzo[d]azepine, novel intermediates and the production thereof
发明人：GAJ STAVBER; CLUZEAU JEROME; RICHTER FRANK; LAUS GERHARD; GAZIC SMILOVIC IVANA
权利人:LEK PHARMACEUTICALS
摘要:The present invention is directed to a simple and economical process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H -benzo[ d ]azepine via novel intermediates and a highly selective asymmetric synthesis leading to enantiopure ( R )-8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H -benzo[ d ] azepine or its ( S )-enantiomer, in order to avoid or overcome chemical optical resolution.