CAS: 2444-37-3; 2-(Methylthio)Acetic Acid

相似化合物

16630-66-3 4455-13-4 5271-38-5

上下游产品

potassium methyl sulfate mercaptoacetic acid dimethyl sulfate methyl iodide Glyoxilic acid dimethylsulfonioacetate -2-(methylthio)acetamideN-methyl-N--2-(methylthio)acetamide N-(o-ethenylphenyl)-N-methyl-2-(methylthio)acetamide

(甲硫基)乙酸乙酯置于potassium Hydroxide,盐酸体系中,用 水 用作溶剂,化学反应 16.0H,反应生成(甲硫基)乙酸
参考文献:3-硫代2-氮杂环丁酮:合成及体外抗菌和抗真菌活性
标题:3-硫代2-氮杂环丁酮:合成及体外抗菌和抗真菌活性
摘要:通过[2 + 2]乙烯酮-亚胺环加成反应,由s-取代的巯基乙酸和席夫碱合成了一系列3-硫醇化的β-内酰胺.然后,某些3-甲硫β内酰胺转化成3-(甲基亚磺酰基),使用β内酰胺和3-(甲磺酰基)β内酰胺米-Cpba不同的反应条件下.所有化合物均通过光谱数据和元素分析进行了表征,并评估了它们对包括金黄色葡萄球菌(耐甲氧西林的菌株)在内的致病菌株的体外抗菌和抗真菌活性.初步筛选结果表明,其中一些化合物具有中等至非常好的抗菌和抗真菌活性.
Doi:10.1016/j.Tet.2011.05.043

专利信息

专利号:US-9376461-B2
优先权日:2011-06-06
标 题:Non-enzymatic synthesis of O-acetyl-ADP-ribose and analogues thereof
发明人：KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B
权利人:KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B; GLAXOSMITHKLINE LLC
摘要:Provided herein is a simple, one-step, non-enzymatic synthesis of O-Acetyl-ADP-ribose (OAADPR) from NAD and sodium acetate in acetic acid. The extension of this reaction to other carboxylic acids, demonstrates that the reaction between NAD, and NAD analogs produces mixtures of the corresponding 2′- and 3′-carboxylic esters. Included are O-carboxyl-ADP-ribose compounds and corresponding methods of synthesis (e.g., O-propionyl-ADP-ribose, O-succinyl-ADP-ribose, O-malonyl-ADP-ribose), as well as non-adenosine nucleoside compounds.

专利号:WO-2024084491-A1
优先权日:2022-10-21
标题:Process for synthesis of res metirom and its intermediates thereof
发明人：MEHTA NILESH VIPINCHANDRA
权利人:MEHTA NILESH VIPINCHANDRA
摘要:The present invention discloses a process for synthesis of Res metirom and its intermediates thereof. More particularly, the invention discloses process for synthesis of a key intermediate, 6-(4-amino, 2,6-dichlorophenoxy)4- isopropylpyridazin-3(2H)-one, of Res metirom via novel intermediate compounds of formula A. Wherein, R is selected from methyl, ethyl and propyl.

专利号:WO-2023021529-A1
优先权日:2021-08-17
标题:Improved enzymatic synthesis of sitagliptin or its salts thereof
发明人：DATLA ANUPAMA; NAGRE PRASHANT; TAMORE JAGDISH; WADHAVANE SACHIN; MURALIDHARAN KRISHNA; TRIVIKRAM SREENATH
权利人:FERMENTA BIOTECH LTD
摘要:The present invention discloses an improved enzymatic synthesis of Sitalgiptin or its pharmaceutically acceptable salts in good yield and purity. The present invention provides novel intermediate (R)- 3-Acetamido-4-(2,4,5-Trifluorophenyl) butanoic acid (5).

专利号:US-5693848-A
优先权日:1994-10-21
标题:α, ω-polymethacrylate dicarboxylic acids, their synthesis and use as dicarboxylic acid components for the synthesis or modification of polyesters, polyurethanes or polyepoxides
发明人：ESSELBORN EBERHARD; FOCK JUERGEN
权利人:GOLDSCHMIDT AG TH
摘要:alpha , omega -polymethacrylate dicarboxylic acids of the general formula wherein R1is an optionally halogenated alkyl group with 1 to 22 carbon atoms, wherein the R1 group can assume different meanings in the polymer molecule, R2 is the group of a known chain transfer agent, which has a terminal -COOH croup and a has a value not less than 4. The invention furthermore relates to the synthesis of these compounds and their use as sole or partial components for the synthesis or modification of polyepoxides, polyesters, polyamides, alkyd resins or polyurethanes.

专利号:US-2009197311-A1
优先权日:2006-06-20
标题:Method for the production of simvastatin
发明人：BERG MARCO ALEXANDER VAN DEN; HANS MARCUS; STREEKSTRA HUGO
权利人:BERG MARCO ALEXANDER VAN DEN; HANS MARCUS; STREEKSTRA HUGO
摘要:The present invention provides a fermentative process for the synthesis of simvastatin by providing a host capable of incorporating the 2,2-dimethylbutyrate side chain into simvastatin, i.e. by customizing a polyketide synthase gene optimized for synthesis and/or incorporation of 2,2-dimethylbutyrate; optionally feeding said host with the appropriate substrate for 2,2-dimethylbutyrate synthesis; fermenting said host to obtain simvastatin or analogues or derivatives thereof, i.e. by producing simvastatin on an industrial scale by a fed-batch process.

专利号:US-2025091989-A1
优先权日:2023-09-19
标 题 :Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.