CAS: 1722-26-5; Borane-Triethylamine Complex

上下游产品

triethylamine sodium tetrahydroborate aziridine borane lithium aluminium tetrahydride1-butyl-piperidine 4-(piperidin-1-yl)butan-2-ol 4-piperidin-1-yl-butan-1-ol 1-(1-piperidyl)-2-butanol

三乙胺置于nickel Boride,三乙胺体系中,用 二氯甲烷 用作溶剂,-78.0~130.0 °C,6.0 Mpa 条件下,反应 16.67H,反应生成三乙胺-硼烷
参考文献:无定形硼化镍催化 Et3Nbcl3 加氢脱氯--一种机理方法
标题:无定形硼化镍催化 Et3Nbcl3 加氢脱氯--一种机理方法
摘要:在叔胺存在下,Bcl3 与分子氢的催化加氢脱氯是一种可行的策略,可以高效地生成有价值的 B-H 键.提出了基于分离中间体实验和氘标记实验的机理研究.来自不溶性 Et3Nhcl 加合物的限速逆反应的发生被确定为 Et3Nbh3 产率低的主要原因.此外,具有 Nch2 单元的胺,在相应的情况下也用作溶剂,对反应动力学有很大的影响;它们直接参与高温下的氢转移并承担助催化剂的作用.提出了在硼化镍催化剂上反应的催化循环.
Doi:10.1002/ejic.201301253

专利信息

专利号:US-2008032964-A1
优先权日:2006-04-10
标题:Process for the synthesis of azetidinone
发明人：KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
权利人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
摘要:Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.

专利号:US-10059599-B2
优先权日:2014-02-03
标 题 :Synthesis of borane compounds
发明人：SAFRONOV ALEXANDER VALENTINOVICH; JALISATGI SATISH SUBRAY; HAWTHORNE MARION FREDERICK
权利人:SAFRONOV ALEXANDER VALENTINOVICH; JALISATGI SATISH SUBRAY; HAWTHORNE MARION FREDERICK; UNIV MISSOURI
摘要:The present invention is directed to a process for the synthesis of alkali metal tetrahydroborates- 10 B and amine borane- 10 B precursors, such as sodium tetrahydroborate- 10 B and triethylamine borane- 10 B.

专利号:US-6875866-B2
优先权日:2002-02-21
标题:Process for synthesis of D1 receptor antagonists
发明人：DAHANUKAR VILAS H; ECKERT JEFFREY M; GALA DINESH; LUCAS BRIAN; SCHUMACHER DORIS P; ZAVIALOV ILIA
权利人:SCHERING CORP
摘要:In one embodiment, the present invention describes the synthesis of a compound of formula n n nand intermediates therefor.

专利号:US-9802934-B2
优先权日:2013-10-17
标 题 :Process for the synthesis of (R)-praziquantel
发明人：QIAN MINGXIN
权利人:TONGLI BIOMEDICAL CO LTD
摘要:The present disclosure relates to a process and new intermediates for the synthesis of (R)-praziquantel, which is obtained through four steps in proper order, that is, condensation reaction, reduction reaction, acylation reaction and ring-closing reaction, using (1R)-2-substituted-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid as starting material. Overall, the present disclosure provides a (R)-praziquantel product with higher optical purity through a process route that is more cost effective and environmentally friendly.

专利号:US-10179795-B2
优先权日:2014-02-03
标题 :Synthesis of amine boranes and polyhedral boranes
发明人：SAFRONOV ALEXANDER VALENTINOVICH; JALISATGI SATISH SUBRAY; HAWTHORNE MARION FREDERICK
权利人:SAFRONOV ALEXANDER VALENTINOVICH; JALISATGI SATISH SUBRAY; HAWTHORNE MARION FREDERICK; UNIV MISSOURI
摘要:The present invention relates in general to a method for the synthesis and purification of 1) the polyhedral borane decahydrodecaborate and dodecahydrododecaborate anions and their salts and 2) amines and amine boranes. The organoammonium halide is combined with alkali metal tetrahydroborate to form organoammonium tetrahydroborate, which upon pyrolysis provides organoammonium decahydrodecaborate and organoammonium dodecahydrododecaborate.

专利号:US-6204405-B1
优先权日:1999-12-22
标 题:Economical and convenient procedures for the synthesis of catecholborane
发明人：BROWN HERBERT C
权利人:SIGMA ALDRICH CO
摘要:New, economical and convenient procedures for the preparation of catecholborane in high chemically pure form using tri-O-phenylene bis borate readily prepared from the reaction of catechol with boric acid, and diborane or borane-Lewis base complexes.