CAS: 156-57-0; 2-Aminoethanethiol Hydrochloride

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2-氯乙胺盐酸盐置于sodium Tetrathiocarbonate,盐酸体系中,用 水 用作溶剂,以95%的收率获得半胱胺盐酸盐
参考文献:制备半胱胺盐酸盐的方法
标题:制备半胱胺盐酸盐的方法
摘要:本发明涉及一种制备半胱胺盐酸盐的方法,包括以下步骤:步骤一,将二硫化碳与硫化钠在酒精中反应得到硫代碳酸钠;步骤二,将2‑氨基乙基硫酸酯钠盐或2‑氯乙胺盐酸盐与步骤一制备得到的硫代碳酸钠充分反应;步骤三,继续加入盐酸进行反应,得到半胱胺盐酸盐一段母液;步骤四,将步骤三所得半胱胺盐酸盐母液冷却析晶,使步骤二反应产生的硫酸钠和/或氯化钠析晶,析晶后过滤,所得滤液为半胱胺盐酸盐二段母液;步骤五,将步骤四得到的半胱胺盐酸盐二段母液减压蒸馏,冷却析晶得到半胱胺盐酸盐固体;所述2‑氨基乙基硫酸酯钠盐或2‑氯乙胺盐酸盐1:1.本发明通过进一步优化,进一步提高了收率,以硫化钠计,其质量收率可达95%.

专利信息

专利号:US-2016075680-A1
优先权日:2013-04-30
标题:Modified solid support for the synthesis of oligonucleotides
发明人：SOMOZA CALATRAVA ALVARO; LATORRE LOZANO ALFONSO
权利人:FUNDACIÓN IMDEA NANOCIENCIA; FUNDACION IMDEA NANOCIENCIA
摘要:The present invention refers to a new solid support for the synthesis of oligonucleotides, to a method for its preparation and to its use in the solid phase synthesis of oligonucleotides.

专利号:US-2024024489-A1
优先权日:2020-11-20
标 题:Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof
发明人：MULARD LAURENCE; DHARA DEBASHIS; PFISTER HELENE; PAOLETTI JULIE; PHALIPON ARMELLE; GUERREIRO-INVERNO CATHERINE
权利人:PASTEUR INSTITUT
摘要:The present invention provides zwitterionic oligosaccharides, in particular fragments of the surface polysaccharides from Shigella sonnei and Shigella sonnei conjugates comprising them. The present invention also provides protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof, the disaccharide repeating unit of Shigella sonnei being: (I)

专利号:US-5919971-A
优先权日:1996-11-22
标题:Process for the synthesis of 3-mercaptopropionic acid esters
发明人：ARRETZ EMMANUEL
权利人:ELF AQUITAINE EXPLORATION PROD
摘要:This process for the synthesis of 3-mercaptopropionic acid esters by addition reaction of H2S to the corresponding acrylic acid ester is carried out in the presence of a solid-support functionalized with basic guanidine functional groups, on condition that these groups are free of hydrogen that is directly attached to a nitrogen atom.

专利号:US-12060315-B2
优先权日:2019-02-14
标 题:Production processes of S- and O-diacylated gamma-glutamyl-cysteamine prodrugs
发明人：ANDERSON ROSALEEN JOY; FROST LISA; BARNWELL NEIL; LEVICK MATTHEW; HALES IVAN; DUNN MICHAEL
权利人:UNIV OF SUNDERLAND
摘要:Methods are provided for the synthesis of a compound of formula (X). R 2 is selected from —H, —C 1 -C 4 -alkyl, —C 2 -C 4 -alkenyl and C 1 -C 4 -aryl; R 3 is selected from —C(O)H and —C(O)C 1 -C 4 -alkyl; and A is a pharmaceutically acceptable anion (e.g. a halide). Also provided are intermediate compounds formed during the synthesis.

专利号:EP-2231627-B1
优先权日:2007-12-03
标题 :New process for the synthesis of moguisteine
发明人：VIGANO' ENRICO; ARRIGHI MASSIMILIANO; MOLTENI RENATO; LANFRANCONI SIMONA; LANDONIO ERNESTO
权利人:A M S A ANONIMA MATERIE SINT E AFFINI S P A
摘要:The invention relates to a process for the synthesis of moguisteine that is ethyl ester of (R,S)-3-[2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidin-3-yl]-3-oxypropanoic acid which comprises the steps of forming a new cyclic intermediate of formula 2-[(2-methoxyphenoxy)methyl]-1,3-dioxolane (4), forming (R,S)-2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidine (6) and reacting this latter with monoethylmalonic acid (7) or a salt thereof. The moguisteine of the invention is obtained in high yield and purity.

专利号:US-5849878-A
优先权日:1993-08-13
标 题 :Design and synthesis of bispecific reagents: use of double stranded DNAs as chemically and spatially defined cross-linkers
发明人：CANTOR CHARLES R; CHUCK ROY S; TSE DORIS B
权利人:UNIV CALIFORNIA
摘要:The invention relates to bis-protein-DNA conjugates. A protein having a specific ligand binding activity is covalently linked to each end of a derivatized DNA molecule. These bis-protein-DNA conjugates can be used for immunoassays, PCR assays and measuring distances between proteins at up to 3.4 A resolution. The invention also relates to methods of synthesizing these bis-protein-DNA conjugates. Synthesis of the conjugates entails derivatizing the 5' or 3' end of a DNA oligonucleotide and covalently linking that DNA to a protein. The DNA can be conjugated to the proteins, including antibodies or Fab' fragments, using disulfide bond linkage.