CAS: 14208-10-7; 1,1'-(1,4-Phenylenebis(Methylene))Bis(Pyridin-1-Ium) Bromide

该化合物是一种四化合物,其特征是硬性p-xyle 空间仪,将两个间元素连接在一起,每个元素都与溴反作用作用.这一结构具有显著的稳定性和回动性,在有机合成,催化和材料科学等应用中很有用.该化合物的双功能性使得其高效交叉或分子识别,而其离子特性则提高了极溶剂的溶解性.其硬性芳烃骨有助于控制超分子组件的空间方向.该溴的肛门进一步促进了核分裂替代或聚合工艺中的金枪鱼再活动.该化合物在设计功能性材料或中间体时的结构精确性和多功能性得到了评价.

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1102-19-8 2589-31-3 2876-13-3

物理性质

MSDS等安全信息

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ECHA物质C&L通报

上下游产品

pyridine 1,4-bis(bromomethyl)benzene 1,1'-bis(phenylmethyl)-4,4'bipyridinium bromideterephthalaldehyde,

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    专利信息


    专利号:US-5272079-A
    优先权日:1988-07-06
    标题 :Purification and administration of DNA repair enzymes
    发明人：YAROSH DANIEL B
    权利人:APPLIED GENETICS INC
    摘要:Methods for purifying DNA repair enzymes are provided in which an aqueous solution of a DNA repair enzyme in an impure state is applied to a molecular sieve column having an exclusion limit which will retard the DNA repair enzyme but will not retard contaminants larger than the DNA repair enzyme. The DNA repair enzyme in an enhanced state of purity is eluted isocratically from the molecular sieve column in an elution buffer and applied directly to a DNA affinity column in the same buffer without intermediate dialysis, ultrafiltration, or other procedures. The DNA repair enzyme is eluted from the DNA affinity column using, for example, a salt gradient. The method is rapid, inexpensive, simple to perform, and has been found to produce a homogeneous final product. In accordance with other aspects of the invention, the purified DNA repair enzymes are encapsulated in liposomes and administered to living cells in situ. This form of administration has been found to be non-toxic to the cells and to result in increased incision of damaged DNA, enhanced DNA repair synthesis, and increased cell survival after exposure to ultraviolet light. In certain preferred embodiments, DNA repair enzymes are administered in pH sensitive liposomes.

    专利号:US-5296231-A
    优先权日:1988-07-06
    标题:Purification and administration of DNA repair enzymes
    发明人：YAROSH DANIEL B
    权利人:APPLIED GENETICS INC
    摘要:PCT No. PCT/US89/02873 Sec. 371 Date Dec. 26, 1990 Sec. 102(e) Date Dec. 26, 1990 PCT Filed Jun. 27, 1989.Methods for purifying DNA repair enzymes are provided in which an aqueous solution of a DNA repair enzyme in an impure state is applied to a molecular sieve column having an exclusion limit which will retard the DNA repair enzyme but will not retard contaminants larger than the DNA repair enzyme. The DNA repair enzyme in an enhanced state of purity is eluted isocratically from the molecular sieve column in an elution buffer and applied directly to a DNA affinity column in the same buffer without intermediate dialysis, ultrafiltration, or other procedures. The DNA repair enzyme is eluted from the DNA affinity column using, for example, a salt gradient. The method is rapid, inexpensive, simple to perform, and has been found to produce a homogeneous final product. In accordance with other aspects of the invention, the purified DNA repair enzymes are encapsulated in liposomes and administered to living cells in situ. This form of administration has been found to be non-toxic to the cells and to result in increased incision of damaged DNA, enhanced DNA repair synthesis, and increased cell survival after exposure to ultraviolet light. In certain preferred embodiments, DNA repair enzymes are administered in pH sensitive liposomes.

    专利号:US-2018371138-A1
    优先权日:2015-12-17
    标题 :Aqueous synthesis and in-situ rapid screening of amphiphilic polymers

    专利号:EP-3390471-A1
    优先权日:2015-12-17
    标 题:Aqueous synthesis and in-situ rapid screening of amphiphilic polymers

    专利号:ES-2618373-B1
    优先权日:2015-12-17
    标 题 :Aqueous synthesis and rapid in situ screening of amphiphilic polymers

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    主要参考文献

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    合成参考文献


    参考文献:10.1007/s002490050225
    摘要:Curtain C, Separovic F, Nielsen K, Craik D, Zhong Y, Kirkpatrick A. The interactions of the N-terminal fusogenic peptide of HIV-1 gp41 with neutral phospholipids. European Biophysics Journal. 1999 Jun 09;28(5):427–36. doi: 10.1007/s002490050225.
    参考文献:10.1016/j.bmcl.2010.01.034
    摘要:Musilek K, Komloova M, Zavadova V, Holas O, Hrabinova M, Pohanka M, Dohnal V, Nachon F, Dolezal M, Kuca K, Jung Y. Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage—initial study for Myasthenia gravis implications. Bioorganic & Medicinal Chemistry Letters. 2010 Mar;20(5):1763–6. doi: 10.1016/j.bmcl.2010.01.034.
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