CAS: 110-51-0; Borane-Pyridine Complex

上下游产品

CAS号110-86-1 吡啶 | CAS号16940-66-2 硼氢化钠 | CAS号628-13-7 吡啶盐酸盐 | CAS号19287-45-7 乙硼烷 | CAS号42976-02-3 hexamethylene t... | CAS号10544-50-0 1,2,3,4,5,6,7,8... | CAS号61289-01-8 [(EtH2N)B8H11NHEt] | CAS号1333-74-0 氢 | CAS号10294-34-5 三氯化硼 | CAS号244761-17-9 lithium tetrahy... | CAS号14289-74-8 tris(2,4,4-trim... | CAS号446065-11-8 环己基三氟硼酸钾 | CAS号1883-35-8 tris(2-phenylet... | CAS号23985-40-2 tricyclopentylborane | CAS号110-86-1 吡啶 | CAS号121-43-7 硼酸三甲酯 | CAS号1333-74-0 氢 | CAS号10043-11-5 氮化硼 | CAS号688-71-1 硼酸三丙酯 | CAS号150-46-9 硼酸三乙酯

Diborane(6)置于吡啶体系中,用 Neat (No Solvent) 用作溶剂,化学反应生成吡啶硼烷
参考文献:Brown,Herbert C.; Murray,Leo T.,Inorganic Chemistry,1984,Vol. 23,# 18,P. 2746-2753
标题:Brown,Herbert C.; Murray,Leo T.,Inorganic Chemistry,1984,Vol. 23,# 18,P. 2746-2753

专利信息

专利号:US-2008032964-A1
优先权日:2006-04-10
标题:Process for the synthesis of azetidinone
发明人：KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
权利人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
摘要:Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.

专利号:US-7767826-B2
优先权日:2007-10-05
标题 :Process for the synthesis of L-(+)-ergothioneine
发明人：TRAMPOTA MIROSLAV
权利人:PHARMATECH INTERNATIONAL INC
摘要:This invention relates to a novel process for the preparation of optically pure L-(+)-ergothioneine. The process for the chemical synthesis of L-ergothioneine comprises steps which consist of reacting L-histidine alkyl ester with an acid halide, chloroformate or pyrocarbonate in the presence of a base, hydrolysis of the alkyl-(S,Z)-2,4,5-triamidopent-4-enoate to obtain a (S)-alkyl 2,5-diamido-4-oxopentanoate, acid catalyzed hydrolysis of the (S)-alkyl 2,5-diamido-4-oxopentanoate followed by reaction with a metal thiocyanate to obtain the thiohistidine, protection of the sulfur of thiohistidine as the tert-butyl thioether, dialkylation of the primary amine to obtain a tertiary amine, quaternization of the tertiary amine, and removal of the protecting group to obtain the desired (S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trialkylammonio)propanoate (I). This process affords a better yield and is capable of practical application at large scale.

专利号:US-10370403-B2
优先权日:2015-04-22
标题 :Methods for the synthesis of ceragenins
发明人：SAVAGE PAUL B; JACKS THOMAS E; MILLER ROSS A; THOMPSON ANDREW S; RANDALL JARED LYNN
权利人:SAVAGE PAUL B; JACKS THOMAS E; MILLER ROSS A; THOMPSON ANDREW S; RANDALL JARED LYNN; UNIV BRIGHAM YOUNG
摘要:Disclosed herein are methods of making ceragnenin compounds for treating, preventing, or diagnosing diseases, disorders, or conditions associated with bacterial or viral infections, cancer, inflammation, and osteogenesis. Ceragenin compounds display broad-spectrum antibacterial activity utilizing a mode of action similar to antimicrobial peptides, but without the high synthesis costs and susceptibility to proteolytic degradation. Ceragenin compounds reproduce the amphiphilic morphology found in many antimicrobial peptides and display potent and diverse biological activities, including anti-bacterial, anti-cancer, anti-inflammatory, bone growth promotion, and wound healing promotion.

专利号:US-2006241298-A1
优先权日:2005-04-21
标 题:Methods for synthesis of dicarbamate compounds and intermediates in the formation thereof
发明人：MORTKO HENRY; HE WEIXUAN; ANDERSEN MARC W; DOTSE ANTHONY K; LI JIE
权利人:MORTKO HENRY; HE WEIXUAN; ANDERSEN MARC W; DOTSE ANTHONY K; LI JIE
摘要:Disclosed is a method of making 2-substituted-2-halo-1,3-propanediols via reduction of corresponding malonate compounds. Also disclosed is a method of making 2-substituted-2-halo-1,3-dicarbamate compounds (such as halo derivatives of felbamate, including fluorofelbamate) via reduction of malonate compounds, followed by carbamoylation. Reduction of the malonate compounds is carried out using an electrophilic hydride reagent.

专利号:US-9125880-B2
优先权日:2002-12-26
标 题:Polymer conjugates of interferon-beta with enhanced biological potency
发明人：SAIFER MARK G P; MARTINEZ ALEXA L; WILLIAMS L DAVID; SHERMAN MERRY R
权利人:SAIFER MARK G P; MARTINEZ ALEXA L; WILLIAMS L DAVID; SHERMAN MERRY R; MOUNTAIN VIEW PHARMACEUTICALS
摘要:Methods are provided for the synthesis of polymer conjugates of cytokines and receptor-binding antagonists thereof, especially a non-glycosylated interferon-beta, which conjugates retain unusually high biological potency. Preparation of polymer conjugates according to the methods of the present invention diminishes or avoids steric inhibition of receptor-ligand interactions that commonly results from the attachment of polymers to receptor-binding regions of cytokines, as well as to agonistic and antagonistic analogs thereof. The invention also provides conjugates and compositions produced by such methods. The conjugates of the present invention retain a high level of biological potency compared to those produced by traditional polymer coupling methods that are not targeted to avoid receptor-binding domains of cytokines. In assays in vitro, the biological potency of the conjugates of non-glycosylated interferon-beta of the present invention is substantially higher than that of unconjugated interferon-beta and is similar to that of interferon-beta-1a that is glycosylated. The conjugates of the present invention also exhibit an extended half-life in vivo compared to the corresponding unconjugated cytokine. The present invention also provides kits comprising such conjugates and/or compositions, and methods of use of such conjugates and compositions in a variety of diagnostic, prophylactic and therapeutic applications, including treatment of multiple sclerosis.

专利号:US-5663368-A
优先权日:1993-07-14
标 题:Synthesis of acid addition salts of hydroxylamines
发明人：FLISAK JOSEPH R; ROSS STEPHEN TOREY
权利人:SMITHKLINE BEECHAM CORP
摘要:This invention relates to novel diastereomeric acid addition salts of homochiral hydroxylamines, to processes for obtaining such, to processes for the conversion thereof to the corresponding homochiral hydroxylamines, to certain novel homochiral hydroxylamines and the processes for using these as intermediates.