CAS: 890652-03-6; 1-(4-Fluorophenyl)-1H-Pyrazole-4-Carbaldehyde

该化合物是有机化合物,其特点是有五人组成的环形结构,含有两个氮原子的七环形化合物,含两种氮原子;含氟苯基组的存在表明,苯基环上替换了氟原子,这可能影响该化合物的电子特性和再活性;在丙烯酸环的4个位置上,甲醛功能组(CHO)有助于其再活动,使它有可能成为各种化学反应,包括凝聚和核生殖添加的候选体;该化合物可能展示生物活动,使其对医药化学和药物开发感兴趣;其独特的结构允许与生物目标的潜在互动,而氟代用可增强脂性性和代谢稳定性;与许多有机化合物一样,由于潜在的毒性或再活性的缘故,应当观察到适当的处理和安全措施.总体而言,1-(4-氟联)-1-丙诺醇-4-丙烯二甲酰胺基甲醚是一种多种化合物,在化学和药理学领域的研发中应用.

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138907-81-0 1152719-74-8 54605-72-0

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1-(4-Fluorophenyl)-1H-Pyrazole 81329-32-0

合成工艺路线路线简述

  • 81329-32-0 = 890652-03-6
    反应条件:1.1 Reagents: Trifluoroacetic Acid; 12 H,Reflux
    标题:New Pyrazole Derivative 5-[1-(4-Fluorophenyl)-1H-Pyrazol-4-Yl]-2H-Tetrazole: Synthesis And Assessment Of Some Biological Activities
    作者:Porfiro De Oliveira,Lanussy; Bueno Da Silva,Daiany Priscilla; Florentino,Iziara Ferreira; Fajemiroye,James Oluwagbamigbe; Sardinha De Oliveira,Thiago; Et Al
    参考文献:Chemical Biology & Drug Design 日期:2017 卷标:89(1) 页码:124-135]

    35344-95-7 = 890652-03-6 + 936940-82-8 + 1015845-52-9
    反应条件:1.1 Reagents: Acetic Acid,Lithium Perchlorate Catalysts: Cyclopropenylium,1,2,3-Tris[(2R,6S)-2,6-Dimethyl-1-Piperidinyl]-,Rel-,Perchlo... Solvents: Acetonitrile; 60 H,Rt
    标题:Electrophotocatalysis With A Trisaminocyclopropenium Radical Dication
    作者:Huang,He; Strater,Zack M.; Rauch,Michael; Shee,James; Sisto,Thomas J.; Et Al
    参考文献:Angewandte Chemie 日期:2019 卷标:58(38) 页码:13318-13322]

    81329-32-0 = 890652-03-6
    反应条件:1.1 Reagents: Trifluoroacetic Acid; 12 H,Reflux1.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized
    标题:Chemoselective And Regiospecific Formylation Of 1-Phenyl-1H-Pyrazoles Through The Duff Reaction
    作者:De Oliveira,C. H. A.; Mairink,L. M.; Pazini,F.; Liao,L. M.; De Oliveira,A. L.; Et Al
    参考文献:Synthetic Communications 日期:2013 卷标:43(12) 页码:1633-1639]

    35344-95-7 = 890652-03-6
    反应条件:1.1 Reagents: Acetic Acid,Tetrabutylammonium Tetrafluoroborate Catalysts: 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone Solvents: Acetonitrile; 36 H,Rt
    标题:Electrophotocatalytic Snar Reactions Of Unactivated Aryl Fluorides At Ambient Temperature And Without Base
    作者:Huang,He; Lambert,Tristan H.
    参考文献:Angewandte Chemie 日期:2020 卷标:59(2) 页码:658-662]

    81329-32-0 = 890652-03-6
    反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Dimethylformamide; -5 °C; 1 H,-5 °C; -5 °C -> 80 °C1.2 80 °C; 5 H,80 °C1.3 Reagents: Water; Overnight,Cooled1.4 Reagents: Sodium Bicarbonate Solvents: Water; Ph 5 - 6
    标题:Synthesis And Characterization Of Novel Arylformoylpyrazole
    作者:Liu,Shu-Yun; Ren,Tie-Gang; Chen,Hong-Bin; Li,Gui-Hui
    参考文献:Henan Daxue Xuebao 日期:2012 卷标:42(2) 页码:154-158]

    35344-95-7 = 890652-03-6
    反应条件:1.1 Catalysts: Antimony Pentachloride,1820760-34-6 Solvents: Acetonitrile; 16 H
    标题:Oxidative Con-Pet Catalysis For Arene Functionalization
    作者:Bieszczad,Bartosz; Karl,Tobias A.; Rolka,Alessa B.; Nuernberger,Patrick; Kutta,Roger J.; Et Al
    参考文献:Chemrxiv 日期:2022 卷标:1 页码:1-49
📜1,4-二氟苯,1H-吡唑-4-甲醛置于tetrabutylammonium Tetrafluoroborate,溶剂黄146,2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 乙腈 作为反应溶剂,化学反应 36.0H,以90%的收率获得产物1-(4-氟苯基)-1H-吡咯-4-甲醛
参考文献:未活化的芳基氟化物在常温和无碱条件下的电光催化sn Ar反应.
标题:未活化的芳基氟化物在常温和无碱条件下的电光催化sn Ar反应.
摘要:证明了在室温下没有强碱的未活化芳基氟化物的电光催化sn Ar反应.
DOI:10.1002/anie.201909983

海关参考信息

专利信息


专利号:US-2011152313-A1
优先权日:2008-06-20
标题 :Synthesis of ageladine a and analogs thereof
发明人：KARUSO PETER HELMUTH; SHENGULE SUDHIR RAMNATHRAO
权利人:UNIV MACQUARIE
摘要:The invention describes a one pot process for synthesizing a compound of structure (I), or a tautomer thereof. A compound of structure (II), or a tautomer thereof, and an aldehyde of structure R d CHO are condensed to form a condensation product. The resulting condensation product is then oxidized in the same reaction mixture to produce the compound of structure (I) or a tautomer thereof.

专利号:WO-2009152584-A1
优先权日:2008-06-20
标题 :Synthesis of ageladine a and analogs thereof

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主要参考文献

参考标题: Synthesis Of Ageladine A And Analogs Thereof Synthèse D'Agéladine A Et D'Analogues De Celle-Ci
摘要:The Invention Describes A One Pot Process For Synthesizing A Compound Of Structure (I), Or A Tautomer Thereof. A Compound Of Structure (II), Or A Tautomer Thereof, And An Aldehyde Of Structure Rdcho Are Condensed To Form A Condensation Product. The Resulting Condensation Product Is Then Oxidized In The Same Reaction Mixture To Produce The Compound Of Structure (I) Or A Tautomer Thereof.

合成参考文献


摘要:Galczynski, J.; Huang, H.; Lambert, T. H., Science of Synthesis: Special Topics, (2021) 1, 325.
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