CAS: 703-95-7; 5-Fluoro-2,6-Dioxo-1,2,3,6-Tetrahydropyrimidine-4-Carboxylic Acid

上下游产品

2-ethylsulfanyl-5-fluoro-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid ethyl ester ethyl 2-(methylmercapto)-4-hydroxy-5-fluoro-6-pyrimidinecarboxylate 5-fluorouracil

在 盐酸体系中,用 水 作为反应溶剂,化学反应 4.0H,以79%的收率获得产物5-氟乳清酸
参考文献:一种絮凝剂添加物5-氟乳清酸的合成工艺
标题:一种絮凝剂添加物5-氟乳清酸的合成工艺
摘要:本发明公开的属于精细化工技术领域,具体为一种絮凝剂添加物5‑氟乳清酸的合成工艺,该絮凝剂添加物5‑氟乳清酸的合成工艺的具体步骤如下:S1:氟乙酸酯与草酸酯在碱性条件下发生缩合反应,缩合反应温度为0~50°C,反应时间为1~10小时;s2:步骤s1中缩合反应后的产物再与o‑甲基异脲盐发生环合反应得到2‑二甲氧基‑4‑羟基‑5‑氟‑6‑甲酸酯嘧啶;s3:2‑二甲氧基‑4‑羟基‑5‑氟‑6‑甲酸酯嘧啶与盐酸发生水解反应,得到5‑氟乳清酸.本方案提供了化合物5‑氟清乳酸的合成工艺路线,此工艺路线步骤短,操作简单,原料易得,成本低,易于纯化,适合工业化生产.

专利信息

专利号:US-7230101-B1
优先权日:2002-08-28
标 题:Synthesis of methotrexate-containing heterodimeric molecules
发明人：MURTHI KRISHNA K; SMITH CHASE C
权利人:GPC BIOTECH INC
摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

专利号:US-6818633-B2
优先权日:2001-06-29
标题:Antiviral compounds and methods for synthesis and therapy
发明人：BALZARINI JAN M R; DE CLERCQ ERIK D A; HOLY ANTONIN
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:Novel compounds are provided having formula (I)whereR1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).

专利号:WO-2022080234-A1
优先权日:2020-10-12
标 题 :Method for modifying genome of algae belonging to genus galdieria
发明人：KOKUBUN Yume; YAMASAKI HIROAKI; MIYAGISHIMA SHIN-YA; HIROOKA Shunsuke; FUJIWARA TAKAYUKI
权利人:DAINIPPON INK & CHEMICALS; INTER UNIV RESEARCH INSTITUTE CORPORATION RESEARCH ORGANIZATION OF INFORMATION AND SYSTEMS
摘要:Provided are: a method for modifying the genome of algae belonging to the genus Galdieria, comprising a step for carrying out genome modification on a haploid form of algae belonging to the genus Galdieria; a method for producing genome-modified algae belonging to the genus Galdieria, comprising a step for carrying out genome modification of algae belonging to the genus Galdieria using the genome modification method; a method for producing a desired substance or food, which uses algae belonging to the genus Galdieria obtained using the production method; and algae belonging to the genus Galdieria, that has a mutation in a gene that participates in the synthesis of a nutrient component and that has a requirement for the nutrient component.

专利号:US-2025263763-A1
优先权日:2020-08-27
标 题 :Production of oxygenated diterpenoid compounds
发明人：ANDERSEN-RANBERG JOHAN; HANSEN NIKOLAJ; FORMAN VICTOR
权利人:UNIV COPENHAGEN
摘要:Disclosed is a method for production of oxygenated diterpenoid compounds, such as triptophenolide, triptonide and triptolide, by inserting genes encoding particular cytochrome P450 enzymes and expressing the genes in selected host cells for synthesis of the compounds. Further disclosed are particular cytochrome P450 enzymes suitable for this synthesis.

专利号:WO-2023164985-A1
优先权日:2022-03-02
标题 :Genetically engineered bacterium for synthesizing p-coumaric acid and derivative thereof, method for constructing same and use thereof
发明人：YU TAO; LUO WEI; GUO SHUYUAN
权利人:SHENZHEN INST OF ADV TECH CAS
摘要:A genetically engineered bacterium for synthesizing p-coumaric acid and derivatives thereof, a method for constructing same and use thereof. The genetically engineered bacterium for synthesizing p-coumaric acid comprises a chassis strain into which a p-coumaric acid synthesis gene has been introduced, and the chassis strain has also been subjected to any one of or a combination of at least two of the following genetic modifications: (1) deleting aro8 and aro9; (2) deleting tdh1, tdh2, tdh3, and overexpressing GAPB; (3) deleting idh1 or idh2, and simultaneously overexpressing YHM2 and IDP2; (4) deleting pgi1, pfk1, or pfk2, and simultaneously overexpressing ZWF1, GND1, RPE1, RKI1, TKL1, and TAL1; (5) overexpressing POS5; or (6) deleting gdh2. Efficient synthesis of p-coumaric acid and derivatives thereof is realized.

专利号:WO-2022043461-A1
优先权日:2020-08-27
标 题 :Production of oxygenated diterpenoid compounds
发明人：ANDERSEN-RANBERG JOHAN; HANSEN NIKOLAJ; FORMAN VICTOR
权利人:UNIV COPENHAGEN
摘要:Disclosed is a method for production of oxygenated diterpenoid compounds, such as triptophenolide, triptonide and triptolide, by inserting genes encoding particular cytochrome P450 enzymes and expressing the genes in selected host cells for synthesis of the compounds. Further disclosed are particular cytochrome P450 enzymes suitable for this synthesis.