CAS: 6959-48-4; 3-(Chloromethyl)Pyridine Hydrochloride

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1007089-84-0 106651-81-4 847610-86-0

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CAS号100-55-0 3-吡啶甲醇 | CAS号500-22-1 吡啶-3-甲醛 | CAS号5654-97-7 7-氮杂-吲哚-2-酮 | CAS号142979-88-2 5,5-bis(pyridin... | CAS号39891-09-3 2-氯-5-吡啶乙腈 | CAS号39244-80-9 1-(3-吡啶甲基)哌嗪 | CAS号42732-49-0 5-甲基-3-羟基吡啶 | CAS号41661-57-8 1-((吡啶-3-基)甲基)-4-哌啶酮 | CAS号2682-86-2 Diethyl (3-pyri... | CAS号79455-30-4 烟拉文 | CAS号3099-31-8 3-氯甲基吡啶 | CAS号864754-21-2 1-(吡啶-3-基甲基)-1H...

3-吡啶甲醇置于氯化亚砜体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 3-氯甲基吡啶盐酸盐
参考文献:Development Of A Reproducible And Scalable Method For The Synthesis Of Biologically Active Pyrazolo[1,5-A]Pyrimidine Derivatives
标题:Development Of A Reproducible And Scalable Method For The Synthesis Of Biologically Active Pyrazolo[1,5-A]Pyrimidine Derivatives
摘要:摘要 为合成一系列 3,6 取代的吡唑并[1,5-A]嘧啶开发了一种可重复和可扩展的方法,该方法是合理设计 Amp 活化蛋白激酶选择性抑制剂的基础.关于新型碳骨架的形成,利用布赫瓦尔德配体在 5,7 二甲基取代的吡唑并[1,5-A]嘧啶的立体受阻位置 6 上形成 C-C 键的 Suzukii-Miyaura 交叉偶联的适用性已经得到证明.
DOI:10.1134/s1070363223050043

专利信息

专利号:US-5434262-A
优先权日:1989-11-09
标题:Process for the synthesis of cyclic polynitrogenated compounds
发明人：GUILARD ROGER; MEUNIER ISABELLE; JEAN CHRISTOPHE; BOISSELIER-COCOLIOS BRIGITTE
权利人:AIR LIQUIDE
摘要:A method for the synthesis of cyclic polyamines preceeds by reaction of a diamine with the acrylonitrile wherein the reduction steps are carried out with Raney alloy instead of using hydrogen under pressure in the presence of Raney nickel. Compounds so prepared have the formula: ##STR1## wherein A and B are: an alkyl chain --(CH 2 )-- in which x is an integer of 2 to 4, substituted or not by an alkyl group of 1 to 5 carbon atoms, which may be substituted or not by an aromatic ring, heterocyclic ring, amine ketone, carboxylic acid, amide, cyano, alkyl, alkoxy, hydroxy, nitro or halogen and R 1 and R 2 are the same moieties as those substituting the alkyl claim above.

专利号:US-6906046-B2
优先权日:2000-12-22
标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes
发明人：JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY
权利人:CELLTECH R & D INC
摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.

专利号:US-4021436-A
优先权日:1974-03-15
标题 :Derivatives of nicotinic acid with amines variously substituted
发明人：CAVAZZA CLAUDIO
权利人:CAVAZZA CLAUDIO
摘要:A novel thionicotinate of nicotinamide is disclosed having the formula: ##STR1## The compound has the useful pharmacological activity of lowering cholesterol, free fatty acid and triglyceride plasma levels. In cases of liver injury, administration of the compound has modified toward normal the injury-induced malfunction of the liver. A synthesis of the compound from nicotinoyl chloride hydrochloride is described as well as modes for the administration of the compound.

专利号:US-4021433-A
优先权日:1973-03-08
标 题:Derivative of nicotinic acid with amides
发明人：CAVAZZA CLAUDIO
权利人:SIGMA TAU IND FARMACEUTI
摘要:A novel cysteine thiolactone of nicotinamide is disclosed having the formula: ##STR1## The compounds, homo-cysteine thiolactone of nicotinamide, and its pharmacologically acceptable salts have the useful pharmacological activity of lowering cholesterol, free fatty acid and triglyceride plasma level in the case of altered lipid metabolism and improving BSP clearance ratio in cases of liver injury. n A synthesis of the compound from nicotinoyl chloride, hydrochloride or nicotinic acid esters is described as well as modes for the administration of the compound.

专利号:US-4100289-A
优先权日:1973-03-08
标 题 :Amidic derivatives of nicotinic acid as therapeutics
发明人：CAVAZZA CLAUDIO
权利人:SIGMA TAU IND FARMACEUTI
摘要:A novel cysteine thiolactone of nicotinamide is disclosed having the formula: ##STR1## The compounds, homo-cysteine thiolactone of nicotinamide, and its pharmacologically acceptable salts have the useful pharmacological activity of lowering cholesterol, free fatty acid and triglyceride plasma level in the case of altered lipid metabolism and improving BSP clearance ratio in cases of liver injury. n A synthesis of the compound from nicotinoyl chloride, hydrochloride or nicotinic acid esters is described as well as modes for the administration of the compound.

专利号:US-4021435-A
优先权日:1974-03-15
标 题 :Derivative of nicotinic acid with amines
发明人：CAVAZZA CLAUDIO
权利人:SIGMA TAU IND FARMACEUTI
摘要:A novel thiazolidide ester of nicotinic acid is disclosed having the formula: ##STR1## The compound has the useful pharmacological activity of lowering cholesterol, free fatty acid and triglyceride plasma levels in cases of malfunctioning lipid metabolism. n A synthesis of the compound from nicotinoyl chloride hydrochloride or nicotinic acid is described as well as modes for the administration of the compound.