CAS: 67776-06-1; S-Nitroso-N-Acetyl-D,L-Penicillamine

该化合物是一种在生物化学和药理研究中广泛使用的氮氧化物(NO)捐献化合物,其稳定的硝基索比醇结构允许在生理条件下有控制的无释放,使其成为研究无源中介信号路径的宝贵工具. SNAP展示了一致和可复制的动能,为精确的实验条件提供了便利.由于它能够模仿本土的NO生产,它对于血管和...

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相似化合物

15537-71-0 2510-38-5 110763-40-1

物理性质

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欧盟法规

ECHA物质C&L通报

上下游产品

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合成工艺路线路线简述

    📜Dl-青霉胺置于盐酸,氢溴酸,Sodium Acetate,Sodium Nitrite体系中,用 甲醇 作为反应溶剂,化学反应 4.5H,反应生成 S-亚硝基-N-乙酰-Dl-青霉胺
    参考文献:Moynihan,Humphrey A.; Roberts,Stanley M.,Journal Of The Chemical Society. Perkin Transactions I,1994,# 7,P. 797-806
    标题:Moynihan,Humphrey A.; Roberts,Stanley M.,Journal Of The Chemical Society. Perkin Transactions I,1994,# 7,P. 797-806

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    专利信息


    专利号:US-12312376-B2
    优先权日:2020-01-24
    标 题:Therapeutic double stranded RNA and methods for producing the same
    发明人：EQUELS THOMAS K; ATODARIA VISHWAJEETSINH M; SCOTT VICTORIA G; STRAYER DAVID R; RODINO PETER W
    权利人:AIM IMMUNOTECH INC
    摘要:Disclosed is a method for the synthesis of a therapeutic double-stranded RNA (tdsRNA), comprising: a) synthesizing a first single-stranded RNA (first ssRNA) in a first synthesis reaction with PNPase as the only RNA polymerase; b) synthesizing a second single-stranded RNA (second ssRNA) in a second synthesis reaction with PNPase as the only RNA polymerase; and c) hybridizing the first ssRNA with the second ssRNA to form the tdsRNA; wherein step a) and step b) are performed in any order. Also disclosed is a product produced by the method.

    专利号:US-9474749-B2
    优先权日:2004-10-01
    标 题 :Morphine and morphine precursors
    发明人：STEFANO GEORGE B; CADET PATRICK; MANTIONE KIRK J; ZHU WEI
    权利人:UNIV NEW YORK STATE RES FOUND
    摘要:Methods and materials related to the use of morphine, morphine precursors (e.g., reticuline), and inhibitors of morphine synthesis or activity to treat diseases, to reduce inflammation, or to restore normal function are provided.

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    合成参考文献


    参考文献:10.1007/s002100100464
    摘要:Müllenheim J, Müller S, Laber U, Thämer V, Meyer W, Bassenge E, Fink B, Kojda G. The effect of high-dose pentaerythritol tetranitrate on the development of nitrate tolerance in rabbits. Naunyn Schmiedebergs Arch Pharmacol. 2001 Sep;364(3):269–75. doi: 10.1007/s002100100464.
    参考文献:10.1016/s0002-9440(10)65121-8
    摘要:Chen F, Lu Y, Castranova V, Rojanasakul Y, Miyahara K, Shizuta Y, Vallyathan V, Shi X, Demers LM. Nitric Oxide Inhibits HIV Tat-Induced NF-κB Activation. The American Journal of Pathology. 1999 Jul;155(1):275–84. doi: 10.1016/s0002-9440(10)65121-8.
    参考文献:10.1007/s00018-002-8449-z
    摘要:Mantione K, Zhu W, Rialas C, Casares F, Cadet P, Franklin AL, Tonnesen J, Stefano GB. Morphine 6 glucuronide stimulates nitric oxide release in mussel neural tissues: evidence for a morphine 6 glucuronide opiate receptor subtype. Cellular and Molecular Life Sciences (CMLS). 2002 Mar 01;59(3):570–4. doi: 10.1007/s00018-002-8449-z.
    参考文献:10.1042/cs20040104
    摘要:Chenevier-Gobeaux C, Morin-Robinet S, Lemarechal H, Poiraudeau S, Ekindjian JC, Borderie D. Effects of pro- and anti-inflammatory cytokines and nitric oxide donors on hyaluronic acid synthesis by synovial cells from patients with rheumatoid arthritis. Clin Sci (Lond). 2004 Sep;107(3):291–6. doi: 10.1042/cs20040104.
    参考文献:10.1080/10611860600648494
    摘要:Fetih G, Fausia H, Okada N, Fujita T, Attia M, Yamamoto A. Colon-specific delivery and enhanced colonic absorption of [Asu1,7]-eel calcitonin using chitosan capsules containing various additives in rats. Journal of Drug Targeting. 2006 Jan;14(3):165–72. doi: 10.1080/10611860600648494.
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