CAS: 63812-15-7; 2-Fluoro-2-Methylpropanoic Acid

相似化合物

3109-99-7 338-76-1 6087-13-4

上下游产品

CAS号55816-69-8 2-氟异丁酸乙酯 | CAS号57-09-0 十六烷基三甲基溴化铵

2-氟异丁酸乙酯置于水,Sodium Hydroxide,盐酸体系中,用 乙醇,水 作为反应溶剂,化学反应 24.0H,以56%的收率获得产物2-氟异丁酸
参考文献:通过可见光诱导的烯烃与 α-氟代羧酸的氢单和二氟烷基化直接合成烷基氟化物
标题:通过可见光诱导的烯烃与 α-氟代羧酸的氢单和二氟烷基化直接合成烷基氟化物
摘要:我们在此报告了第一个可见光诱导的烯烃与廉价且易于获得的 α-氟代羧酸的氢单和二氟烷基化反应.这种无金属协议表现出温和的条件,高效率和出色的官能团耐受性,为单氟烷基化烷烃和二氟烷基化烷烃提供了一种直接的方法.此外,详细讨论了氟对氢氟烷基化反应的影响.
DOI:10.1021/acs.Joc.2C00965

专利信息

专利号:US-4273947-A
优先权日:1979-01-31
标 题:Hydrogenation of fluorine-containing carboxylic acids
发明人：NOVOTNY MIROSLAV
权利人:ALLIED CHEM
摘要:A process is described for the heterogeneous hydrogenation of fluorine-containing alkyl, cycloalkyl, and benzene carboxylic acids to the corresponding primary alcohols. The hydrogenation can be carried out in the liquid or vapor phase in the presence of a solid rhodium or iridium catalyst, employed as the metal, metallic oxide, or mixture thereof. In the liquid phase, the hydrogenation can be carried out batchwise under mild conditions of temperature and pressure, preferably at about 50°-150° C. and about 5-15 atmospheres, in an atmosphere containing hydrogen gas. A preferred embodiment is the hydrogenation of trifluoroacetic acid in the liquid phase to 2,2,2-trifluoroethanol, said alcohol being useful as an intermediate in the synthesis of the anesthetic, isoflurane, CF 3 CHClOCHF 2 .

专利号:US-8093421-B2
优先权日:2006-10-27
标题 :Stereoselective one step fluorination process for the preparation of 2-flouropropionate
发明人：LUI NORBERT; PAZENOK SERGII
权利人:LUI NORBERT; PAZENOK SERGII; BAYER CROPSCIENCE AG
摘要:The current invention describes a one-step process for the synthesis of 2-fluoropropionates from lactic acid ester derivatives using TFEDMA.

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:DK-2725028-T3
优先权日:2008-10-22
标题:Substituted pyrazolo [1,5-a] pyrimidine compounds as intermediates in the synthesis of kinase inhibitors TRK

专利号:EP-2231679-B1
优先权日:2007-12-14
标 题 :Synthesis of biguanidines and triazines, and biguanidino-aluminium complexes as intermediates

专利号:EP-2725028-A1
优先权日:2008-10-22
标题 :Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors