CAS: 61270-71-1; (6R,7R)-7-Amino-8-Oxo-3-[[1-(Sulfomethyl)Tetrazol-5-Yl]Sulfanylmethyl]-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid

主要参考文献

参考标题:Influence Of Substrate Structure On Pga-Catalyzed Acylations. Evaluation Of Different Approaches For The Enzymatic Synthesis Of Cefonicid
作者:Marco Terreni,Joseph Gapesie Tchamkam,Umberto Sarnataro,Silvia Rocchietti,Roberto Fernández-Lafuente,José M. Guisán |发布日期:2005.1
摘要:Centre Of Pga. The Enzymatic Acylation Of These Nuclei With R-Methyl Mandelate Has Been Studied In Order To Evaluate Different Approaches For The Enzymatic Synthesis Of Cefonicid. The Best Results Have Been Obtained In The Acylation Of 7-Saca. Cefonicid (8) Was Recovered From The Reaction Mixture As The Disodium Salt In 65% Yield And About 95% Of Purity. Furthermore, Through Acylation Of 7-Aca, A "One-Pot"