CAS: 5792-36-9; 2,4-Dihydroxypropiophenone

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📜1,3-苯二醇单乙酸酯置于咪唑,Acyltransferase From Bacterium Pseudomonas Sp.Ygj3体系中,用 Aq. Phosphate Buffer,二甲基亚砜 作为反应溶剂,化学反应 42.0H,反应生成 2,4-二羟基苯丙酮
参考文献:生物催化弗里德尔-克来福特酰化和弗里斯反应.
标题:生物催化弗里德尔-克来福特酰化和弗里斯反应.
摘要:弗里德尔-克来福特酰化通常用于芳基酮的合成,并且尚未引入可能受益于酶的化学和区域选择性的生物催化版本.这里描述的是一种细菌酰基转移酶,它可以催化缓冲液中酚类底物的 Friedel-Crafts C-酰化,而不需要 Coa 激活试剂.转化率高达 >99%,并且该酶接受各种 C-或 O-酰基供体,例如 Dapg 或乙酸异丙烯酯.此外,该酶能够使间苯二酚衍生物发生类似弗里斯重排的反应.这些发现为开发替代性和选择性 Cc 键形成方法开辟了道路.
DOI:10.1002/anie.201703270

专利信息

专利号:US-2006129002-A1
优先权日:2004-12-15
标 题:Process for the synthesis of alkylresorcinols
发明人：WASSMANN-WILKEN SUZANNE; SCHMIDT HANS-JURGEN; WILKEN JORG; KANSCHIK-CONRADSEN ANDREAS
权利人:HONEYWELL INT INC
摘要:The invention provides a process for the production of 4-(C 2 -C 16 )alkylresorcinol. 4-(C 2 -C 16 )alkylresorcinol is produced by reacting resorcinol with a (C 2 -C 16 )alkyloic acid in the presence of a zinc chloride catalyst to produce an intermediate comprising a 4-(C 2 -C 16 )acylresorcinol and zinc ions. Then the intermediate is adjusted such that the zinc ion content is from about 0.1 to about 150 parts per million based on the weight of the intermediate to form an adjusted intermediate. Then the produced 4-(C 2 -C 16 )acylresorcinol is hydrogenated in the presence of the zinc ions and a base metal hydrogenation catalyst to produce a crude product comprising 4-(C 2 -C 16 )alkylresorcinol, which may thereafter be isolated.

专利号:US-7405310-B2
优先权日:2001-03-05
标 题:Non-nucleoside reverse transcriptase inhibitors
发明人：LINDSTROM STEFAN; SAHLBERG CHRISTER; WALLBERG HANS; KALYANOV GENAIDY; ODEN LOURDES SALVADOR; NAESLUND LOTTA
权利人:MEDIVIR AB
摘要:This invention relates to non-nucleoside reverse transcriptase inhibitors active against HIV-1 and having an improved resistance and pharmacokinetic profile. The invention further relates to novel intermediates in the synthesis of such compounds and the use of the compounds in antiviral methods and compositions.

专利号:US-9782363-B2
优先权日:2012-10-12
标 题 :Anti-virulance compositions and methods
发明人：SHOHAM MENACHEM; VISWANATHAN RAJESH; YU GUANPING
权利人:UNIV CASE WESTERN RESERVE
摘要:A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) or an ortholog of AgrA includes administering to the bacterium an amount of a pharmaceutical composition effective to inhibit the synthesis of one or more virulence factors by the bacterium, the pharmaceutical composition including an AgrA antagonist.

专利号:US-7427690-B2
优先权日:2004-06-05
标 题 :Multifunction “crown complexesâ€? from amino acids and peptides for skin and hair restoration
发明人：GUPTA SHYAM K
权利人:BIODERM RESEARCH
摘要:This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2 . The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.