CAS: 556-89-8; Nitrourea

化学文摘社编号556-89-8,其独特的结构特征是硝化物组(-NO2),附于尿素协会,通常看起来像是白色晶状固体,在水和各种有机溶剂中可溶解.硝酸尿在农业领域作为除草剂和在其他化学化合物合成中的潜在应用是众所周知的.硝酸胶组的存在有助于其再活性,使其成为各种化学反应的受体.此外,硝酸可以进行水解,导致在某些条件下形成尿素和硝酸.在处理硝酸时,安全考虑十分重要,因为如果浸入或吸入,可能会对健康造成危害,因此应当采取适当的预防措施,以尽量减少接触.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

uronium nitrate acetic anhydride nitric acid acetic acidmethylnitroamine methyl is°Cyanate 4-(2-hydroxy-ethyl)-piperazine-1-carboxylic acid amide 2-thiazolin2-Ureido-Δ2-thiazolin

合成工艺路线路线简述

    Potassium Nitrocyanamide置于硫酸体系中,用5.8 G的收率获得产物硝基脲
    参考文献:强无机酸中硝基氰的形成与分解
    标题:强无机酸中硝基氰的形成与分解
    摘要:Nitrourea Is The Major Product Of Acid-Catalyzed Decomposition Of Nitrocyanamide. Study Of The Kinetics Of This Process In Aqueous Sulfuric And Nitric Acid Unexpectedly Revealed A Fairly High Resistance Of Nitrocyanamide To Acids,So That It Can Be Synthesized Not Only In Alkaline But Also In Strongly Acid Media.
    DOI:10.1023/a:1021639410066

    专利信息


    专利号:US-5183903-A
    优先权日:1991-11-26
    标题:Urea fusion process for the synthesis of 3-phenoxy-1-azetidinecarboxamides
    发明人:WELSTEAD JR WILLIAM J; LO YOUNG S
    权利人:ROBINS CO INC A H
    摘要:This invention relates to an improved process for the preparation of 3-phenoxy-1-azetidinecarboxamides of Formula I which are useful ##STR1## in the treatment of epileptic seizures. Under Formula I, n is 1 to 3, X is H, halogen, trifluoromethyl, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, acetyl, or aminocarbonyl, and R is H or methyl. This process involves heating a 3-phenoxyazetidine with urea to obtain the Formula I compound. Urea is inexpensive and easily removed by washing the solid Formula I product with water.

    专利号:US-2022161250-A1
    优先权日:2019-04-01
    标题:Co-deflagration synthesis of metallic, ceramic, and mixed ceramic-metallic particles
    发明人:ROSEN BRIAN ASHLEY; GOZIN MICHAEL; KOMARALA ESWARA VARA PRASADARAO; FADEEV LUDMILA
    权利人:TECH INNOVATION MOMENTUM FUND ISRAEL LIMITED PARTNERSHIP
    摘要:A co-deflagration process for the preparation of metallic, ceramic, or mixed ceramic-metallic particles optionally impregnated within or attached to a metallic, ceramic, or mixed ceramic-metallic support material includes mixing at least two components. Each of the components can be any of a nitrogen-rich ligand or a salt thereof, a complex or coordination polymer of the nitrogen-rich ligand or salt thereof with one of the at least one metal, and a cluster of the at least one metal, and optionally an organic or inorganic oxidant, gas generator, pyrotechnic, propellant, and/or explosive.

    专利号:US-6667406-B1
    优先权日:1999-03-10
    标题 :Methods for the synthesis of complex reduced isoindole, isooxyindole and isooxyquinoline libraries
    发明人:SUN SENGEN; MURRAY WILLIAM V
    权利人:ORTHO MCNEIL PHARM INC
    摘要:Disclosed are methods of synthesizing libraries of diverse complex hexahydroisoindole, hexahydroisooxyindole and octahydroisooxyquinoline compounds through the use of a facile intramolecular Diels Alder reaction. The invention is further directed to methods for synthesizing the libraries on solid supports. The invention is further directed to methods for identifying and isolating such hexahydroisoindole, hexahydroisooxyindole and octahydroisooxyquinoline compounds with useful and diverse activities from such libraries.

    专利号:EP-0019223-A1
    优先权日:1979-05-09
    标 题 :Optically active hydantoin derivatives, their synthesis, pharmaceutical formulations containing them, and intermediates
    发明人:WHITTAKER NORMAN
    权利人:WELLCOME FOUND
    摘要:Compounds of formula (I)n having only two optically active centres, may exist as four isomers, each of which may be prepared by resolving a racemic amino-diester intermediate in the preparation thereof. The racemic amino-diester is selectively hydrolysed to the corresponding mono-ester which is acylated and subsequently selectively deacylated to produce the resolved mono-ester. n Isomers of compounds of formula (I) having a particular configuration are biologically more active than the corresponding isomers having other configurations and are useful in medicine, either as the raw compound or in a pharmaceutical formulation, for example in inhibiting platelet aggregation.

    专利号:RU-2030396-C1
    优先权日:1990-10-22
    标 题:Method of synthesis of 5-chloro-2-amino-substituted benzhydrylureas

    专利号:CN-118159296-A
    优先权日:2021-09-30
    标题:Automated Synthesis of Polymeric Double Drugs
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    合成参考文献


    摘要:2024 Emergency Response Guidebook,
    摘要:Li, W-R., Science of Synthesis, (2005) 21, 189.
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