Potassium Nitrocyanamide置于硫酸体系中,用5.8 G的收率获得产物硝基脲 参考文献:强无机酸中硝基氰的形成与分解 标题:强无机酸中硝基氰的形成与分解 摘要:Nitrourea Is The Major Product Of Acid-Catalyzed Decomposition Of Nitrocyanamide. Study Of The Kinetics Of This Process In Aqueous Sulfuric And Nitric Acid Unexpectedly Revealed A Fairly High Resistance Of Nitrocyanamide To Acids,So That It Can Be Synthesized Not Only In Alkaline But Also In Strongly Acid Media. DOI:10.1023/a:1021639410066
专利信息
专利号:US-5183903-A 优先权日:1991-11-26 标题:Urea fusion process for the synthesis of 3-phenoxy-1-azetidinecarboxamides 发明人:WELSTEAD JR WILLIAM J; LO YOUNG S 权利人:ROBINS CO INC A H 摘要:This invention relates to an improved process for the preparation of 3-phenoxy-1-azetidinecarboxamides of Formula I which are useful ##STR1## in the treatment of epileptic seizures. Under Formula I, n is 1 to 3, X is H, halogen, trifluoromethyl, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, acetyl, or aminocarbonyl, and R is H or methyl. This process involves heating a 3-phenoxyazetidine with urea to obtain the Formula I compound. Urea is inexpensive and easily removed by washing the solid Formula I product with water.
专利号:US-2022161250-A1 优先权日:2019-04-01 标题:Co-deflagration synthesis of metallic, ceramic, and mixed ceramic-metallic particles 发明人:ROSEN BRIAN ASHLEY; GOZIN MICHAEL; KOMARALA ESWARA VARA PRASADARAO; FADEEV LUDMILA 权利人:TECH INNOVATION MOMENTUM FUND ISRAEL LIMITED PARTNERSHIP 摘要:A co-deflagration process for the preparation of metallic, ceramic, or mixed ceramic-metallic particles optionally impregnated within or attached to a metallic, ceramic, or mixed ceramic-metallic support material includes mixing at least two components. Each of the components can be any of a nitrogen-rich ligand or a salt thereof, a complex or coordination polymer of the nitrogen-rich ligand or salt thereof with one of the at least one metal, and a cluster of the at least one metal, and optionally an organic or inorganic oxidant, gas generator, pyrotechnic, propellant, and/or explosive.
专利号:US-6667406-B1 优先权日:1999-03-10 标题 :Methods for the synthesis of complex reduced isoindole, isooxyindole and isooxyquinoline libraries 发明人:SUN SENGEN; MURRAY WILLIAM V 权利人:ORTHO MCNEIL PHARM INC 摘要:Disclosed are methods of synthesizing libraries of diverse complex hexahydroisoindole, hexahydroisooxyindole and octahydroisooxyquinoline compounds through the use of a facile intramolecular Diels Alder reaction. The invention is further directed to methods for synthesizing the libraries on solid supports. The invention is further directed to methods for identifying and isolating such hexahydroisoindole, hexahydroisooxyindole and octahydroisooxyquinoline compounds with useful and diverse activities from such libraries.
专利号:EP-0019223-A1 优先权日:1979-05-09 标 题 :Optically active hydantoin derivatives, their synthesis, pharmaceutical formulations containing them, and intermediates 发明人:WHITTAKER NORMAN 权利人:WELLCOME FOUND 摘要:Compounds of formula (I)n having only two optically active centres, may exist as four isomers, each of which may be prepared by resolving a racemic amino-diester intermediate in the preparation thereof. The racemic amino-diester is selectively hydrolysed to the corresponding mono-ester which is acylated and subsequently selectively deacylated to produce the resolved mono-ester. n Isomers of compounds of formula (I) having a particular configuration are biologically more active than the corresponding isomers having other configurations and are useful in medicine, either as the raw compound or in a pharmaceutical formulation, for example in inhibiting platelet aggregation.
专利号:RU-2030396-C1 优先权日:1990-10-22 标 题:Method of synthesis of 5-chloro-2-amino-substituted benzhydrylureas
专利号:CN-118159296-A 优先权日:2021-09-30 标题:Automated Synthesis of Polymeric Double Drugs