CAS: 511-28-4; Vitamin D4 (Impurity)

相似化合物

65445-14-9 511-28-4 116559-84-3

上下游产品

CAS号71805-76-0 (1R,3aR,4R,5R,7... | CAS号71805-88-4 (1R,3aR,4R,7aR)... | CAS号71805-86-2 (S,Z)-4-methyle... | CAS号71830-70-1 (1R,3aR,4S,7aR)...

📜(1R,3Ar,4S,7Ar)-4-Benzenesulfonyl-7A-Methyl-1-[(1R,4S)-1,4,5-Trimethyl-Hexyl]-octahydroindene置于sodium Amalgam体系中,化学反应生成 维生素d4
参考文献:Kocienski,P.J. Et Al.,Journal Of The Chemical Society. Perkin Transactions I,1979,P. 1290-1293
标题:Kocienski,P.J. Et Al.,Journal Of The Chemical Society. Perkin Transactions I,1979,P. 1290-1293

专利信息

专利号:US-5869472-A
优先权日:1994-07-18
标 题 :Synthesis of 1α-hydroxy vitamin D
发明人：MORIARTY ROBERT M; GUO LIANG; PENMASTA RAJU A
权利人:BONE CARE INT INC
摘要:A method for 1α-hydroxylation of vitamin D compounds using the appropriate vitamin D as the starting material. The method requires no separatory procedures prior to the actual hydroxylation step.

专利号:US-9212137-B2
优先权日:2012-05-30
标题:Crystallization of (20R,22R)-2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 and related precursors
发明人：DELUCA HECTOR F; GRZYWACZ PAWEL; PLUM LORI A; FLORES AGNIESZKA; THODEN JAMES B; HOLDEN HAZEL M
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Disclosed are methods of purifying the compound (20R,22R)-2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D 3 to obtain the compound in crystalline form. The methods typically include the steps of dissolving a product containing the compound in a solvent comprising hexane and 2-propanol, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of crystals, and recovering the crystals. Certain diol precursors formed during the synthesis of the compound and its diasteromers also may be obtained in crystalline form using ethyl acetate as a solvent.

专利号:AU-7364094-A
优先权日:1994-07-18
标题 :Synthesis of 1alpha-hydroxy vitamin d

专利号:CA-2195414-A1
优先权日:1994-07-18
标 题 :Synthesis of 1.alpha.-hydroxy vitamin d

专利号:US-6281249-B1
优先权日:1997-07-21
标题:18-substituted-19-nor-vitamin D compounds
发明人：DELUCA HECTOR F; CAI ZU Y
权利人:WISCONSIN ALUMNI RES FOUND
摘要:This invention provides a novel class of vitamin D compounds, namely, 13-ethyl and 13-vinyl-18,19-dinor-vitamin D derivatives, as well as a general method for their chemical synthesis. The compounds have the formula: n where Y 1 and Y 2 , which may be the same or different, are each selected from the group consisting of hydrogen and a hydroxy-protecting group, R 6 is selected from the group consisting of an ethyl or vinyl radical, and where the group R represents any of the typical side chains known for vitamin D type compounds. These 18-substituted compounds are characterized by minimal intestinal calcium transport activity and minimal bone calcium mobilization activity resulting in novel therapeutic agents for the treatment of secondary hyperparathyroidism. These compounds also exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as anti-cancer agents and for the treatment of diseases such as psoriasis.

专利号:US-6359152-B2
优先权日:1997-07-21
标 题 :18-substituted-19-nor-vitamin D compounds
发明人：DELUCA HECTOR F; CAI ZU Y
权利人:WISCONSIN ALUMNI RES FOUND
摘要:This invention provides a novel class of vitamin D compounds, namely, 13-ethyl and 13-vinyl-18,19-dinor-vitamin D derivatives, as well as a general method for their chemical synthesis. The compounds have the formula: n where Y 1 and Y 2 , which may be the same or different, are each selected from the group consisting of hydrogen and a hydroxy-protecting group, R 6 is selected from the group consisting of an ethyl or vinyl radical, and where the group R represents any of the typical side chains known for vitamin D type compounds. These 18-substituted compounds are characterized by minimal intestinal calcium transport activity and minimal bone calcium mobilization activity resulting in novel therapeutic agents for the treatment of secondary hyperparathyroidism. These compounds also exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as anti-cancer agents and for the treatment of diseases such as psoriasis.