CAS: 4930-98-7; 2-Hydrazinylpyridine

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2-氯吡啶置于hydrazine Hydrate体系中,用 丙醇 作为反应溶剂,化学反应 20.0H,以93%的收率获得产物2-肼吡啶
参考文献:通过亲核芳香取代合成肼基吡啶并进一步转化为带有两个n-氨基琥珀酰亚胺部分的双环[2.2.2]辛烯
标题:通过亲核芳香取代合成肼基吡啶并进一步转化为带有两个n-氨基琥珀酰亚胺部分的双环[2.2.2]辛烯
摘要:摘要 提出了通过在不同的氯吡啶中氯取代基的亲核取代,在厚壁ace管中高效可靠地合成取代的肼基吡啶的方法.水合肼和烷基肼被用作亲核试剂,简单的醇和乙醚是唯一必需的有机溶剂,使该方法对环境和用户友好,有可能达到100%的原子效率.在下一步中,通过氧的亲核取代,将与双环[2.2.2]辛烯骨架融合的琥珀酸酐部分转化为琥珀酰亚胺部分.作为亲核试剂,使用了两种合成的肼基吡啶(2-肼基-3-硝基吡啶和2-肼基-5-硝基吡啶)以及水合肼,苯肼和4-硝基苯肼.再次在ace管中进行反应,仅需要简单的醇,二乙醚和丙酮作作为反应溶剂.制备的双环[2.2.2]辛烯加合物之一显示出水溶性,因此作为水溶液中各种金属阳离子的新型双齿配体或作为前所未有的卤素键受体,是未来研究的有希望的候选者. 出版历史 收到:2020年7月21日 修订后接受:2020年9月4日 发布日期: 2020年10月12日(在线) ©2020年.thieme.版权所有
DOI:10.1055/s-0040-1706481

专利信息

专利号:US-9221821-B2
优先权日:2012-06-05
标题:Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds
发明人：DIEP NHUT; KALYAN YURIY B
权利人:FOREST LAB HOLDINGS LTD; FOREST LAB HOLDINGS LTD
摘要:Methods for the synthesis of disubstituted aminouracils and xanthine and/or xanthine-related compounds are provided.

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-2023018429-A1
优先权日:2019-11-22
标 题 :Process for synthesis of (3-chloro-2-pyridyl)hydrazine
发明人：CHOCKALINGAM DEVARAJAN; DUDHAT VIPUL; KHARATKAR RAJU MAHADEV; MAO JIANHUA; VEKARIYA PANKAJKUMAR; BHATT DHARMESH BALVANTRAI
权利人:FMC CORP; FMC AGRO SINGAPORE PTE LTD
摘要:Described herein are novel methods of synthesizing (3-chloro-2-pyridyl)hydrazine. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.

专利号:US-9469603-B2
优先权日:2012-03-12
标 题 :Reaction product of hydrazine derivatives and carbon dioxide
发明人：HUR NAM HWI; LEE BYEONG NO
权利人:UNIV SOGANG RES FOUNDATION
摘要:The present invention relates to the synthesis of a novel compound, in which liquid hydrazine and the derivatives thereof react with excess carbon dioxide to enable the carbon dioxide to chemically bond to the hydrazine and the derivatives thereof. To this end, high-pressure carbon dioxide is used to synthesize hydrazine and the derivatives thereof to which the carbon dioxide is bonded in a pure form with no water and no by-product. Furthermore, the present invention provides a method for utilizing the above-described compounds by reacting the compounds with carbonyl compounds.

专利号:US-8895747-B2
优先权日:2009-07-27
标 题 :Method and substances for preparation of N-substituted pyridinium compounds
发明人：HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL
权利人:HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL; ROCHE DIAGNOSTICS OPERATIONS
摘要:Methods for the synthesis of N-substituted pyridinium compounds by using an N-heteroaryl substituted pyridinium salt (Zincke salt) and reacting it with a nucleophilic amine are provided. Novel purine-substituted pyridyl compounds, which may be useful reagents in the above reaction, are also disclosed.

专利号:US-11053243-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.