CAS: 4920-80-3; 3-Methoxy-2-Nitrobenzoic Acid

该化合物是一种有机化合物,其特点是芳香结构,包括一个混合体组(-OCH)和一个附属于苯并硫框架的硝酸组(-NO),这些功能组的存在具有独特的化学特性,例如,由于盒状酸组和电益替代反应的可能性而增加酸性,这种化合物在室内温度上一般是固体,可溶于有机溶剂,而其溶解于水的溶解性可能因芳香环的疏水性而受到限制.硝酸组是一个强大的电排层组,可以影响化合物在各种化学反应中的再活动,包括核聚变换和减少.此外,3-Methoxy-2-notrobenzoic酸可能展示生物活动,从而引起对制药和农用化学研究的兴趣.应参考安全数据来处理,因为硝酸化合物可能具有危险性.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号5345-42-6 3-甲基-2-硝基苯甲醚 | CAS号4920-77-8 2-硝基间甲酚 | CAS号108-39-4 间甲酚 | CAS号53055-05-3 3-甲氧基-2-硝基苯甲醛 | CAS号586-38-9 3-甲氧基苯甲酸 | CAS号591-31-1 3-甲氧基苯甲醛 | CAS号4900-66-7 2-甲氧基-1-硝基萘 | CAS号99-06-9 3-羟基苯甲酸 | CAS号108-24-7 乙酸酐 | CAS号7697-37-2 硝酸 | CAS号37466-89-0 1,2-二氨基-3-甲氧基苯 | CAS号3177-80-8 2-氨基-3-甲氧基苯甲酸 | CAS号42465-54-3 1-(2-氨基-3-甲氧基-苯基)-乙酮 | CAS号446-61-7 2-氟-6-甲氧基苯胺 | CAS号20876-31-7 3-甲氧基-2-硝基苯乙酸 | CAS号99595-85-4 3-甲氧基-2-硝基苯甲酰胺 | CAS号88377-31-5 5-甲氧基-9-氧代-9,10... | CAS号602-00-6 3-羟基-2-硝基苯甲酸 | CAS号1426317-26-1 3-hydroxy-6-iod... | CAS号5472-99-1 1-氯-3-甲氧基-2-硝基苯

合成工艺路线路线简述

    📜3-甲氧基-2-硝基苯甲醛置于potassium Permanganate体系中,化学反应生成 3-甲氧基-2-硝基苯甲酸
    参考文献:Rieche,Chemische Berichte,1889,Vol. 22,P. 2354
    标题:Rieche,Chemische Berichte,1889,Vol. 22,P. 2354

    海关参考信息

    专利信息


    专利号:US-10889574-B2
    优先权日:2016-06-17
    标 题 :Method for producing diphenylmethane derivative
    发明人：YOON HEE-KYOON; PARK SE-HWAN; YOON JI-SUNG; CHOI SOONGYU; SEO HEE JEONG; PARK EUN-JUNG; KONG YOUNGGYU; SONG KWANG-SEOP; KIM MIN JU; PARK SO OK
    权利人:DAE WOONG PHARMA; GREEN CROSS CORP
    摘要:The present invention relates to an improved method for producing a diphenylmethane derivative which is effective as a sodium-dependent glucose cotransporter (SGLT) inhibitor, the method being carried out by means of a convergent synthesis method in which each major group is separately synthesized and then coupled. As such, in comparison to a linear synthesis method disclosed in existing documents, the synthesis pathway is compact and yield can be increased, and risk factors inherent in the linear synthesis pathway can be reduced. Furthermore, the crystal form of the compound produced according to the method has superb physicochemical characteristics, and thus can be effectively utilized in fields such as pharmaceutical manufacturing.

    专利号:CN-111138398-A
    优先权日:2019-12-31
    标题:Synthesis process of 2- (2-amino-3-methoxyphenyl) chromone

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    主要参考文献

    参考标题:New Methods And Reagents In Organic Synthesis. 92. A Stereoselective Synthesis Of Tilivalline And Its Analogs
    作者:Shigehiro Mori,Tomoyasu Ohno,Hiroshi Harada,Toyohiko Aoyama,Takayuki Shioiri
    摘要:Tilivalline (1A), A Metabolite From Klebsiella Pneumoniae Var. Oxytoca, And Its Derivatives 1 Have Been Efficiently And Stereoselectively Synthesized From Diphenyl Phosphorazidate, The 2-Oxazoline 2, The L-Proline Derivatives 5, And Indole; The Key Step Is A Mannich Type Intramolecular Cyclization Accompanied With Completely Stereoselective Introduction Of Indole. Furthermore, 11-Substituted 5H- Pyrrolo[2

    合成参考文献


    参考文献:10.1007/bf00579819
    摘要:D'yakonov AL, Telezhenetskaya MV, Yunusov LY. Synthetic analogues of Peganum alkaloids. III. Pentamethylenequinazolones. Chemistry of Natural Compounds. 1986 Jul;22(4):435–8. doi: 10.1007/bf00579819.
    参考文献:10.1007/s10847-014-0384-8
    摘要:Rapi Z, Bakó P, Keglevich G, Baranyai P, Kubinyi M, Varga O. Synthesis and recognition properties of α-d-glucose-based fluorescent crown ethers incorporating an acridine unit. Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2014 Feb 01;80(3-4):253–61. doi: 10.1007/s10847-014-0384-8.
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