CAS: 4753-04-2; 2'-Chloro-2'-Deoxyuridine

相似化合物

951-78-0 784-71-4 69123-94-0

上下游产品

CAS号3736-77-4 2,2'-脱水尿苷

📜2,2'-脱水尿苷置于三氯化铝体系中,用95%的收率获得产物2'-氯-2'-脱氧尿苷
参考文献:在bf 3 .et 2 O存在下2,2'-脱水尿苷与氰基乙基三甲基甲硅烷基醚的开环反应,轻松合成2'-O-氰基乙基尿苷
标题:在bf 3 .et 2 O存在下2,2'-脱水尿苷与氰基乙基三甲基甲硅烷基醚的开环反应,轻松合成2'-O-氰基乙基尿苷
摘要:在这种信,对于2'-合成的简便方法ô-Cyanoethyluridine,这是在充分的合成部分2'-O-氰乙基化寡核糖核苷酸以及未修饰的寡核糖核苷酸的关键中间体,并通过开环开发bf 3 .et 2 O存在下,在二甲基乙酰胺中,使2,2'-脱水尿苷与2-氰基乙基三甲基甲硅烷基醚反应.2'-ô-Cyanoethyluridine 3'-亚磷酰胺衍生物转化成2'-ø氰乙基-4-ñ由一系列涉及4-取代反应(1个-Acetylcytidine 3'-亚磷酰胺衍生物ħ-1,2,4-三唑-1-基)尿苷衍生物与氨的反应,然后进行乙酰化.
DOI:10.1016/j.Tetlet.2007.09.105

专利信息

专利号:US-3873516-A
优先权日:1973-05-29
标 题:Process for the preparation of 1-{8 {62 -D-2-substituted-2-deoxyribofuranosyl{9 -pyrimidines
发明人：KOTICK MICHAEL PAUL; POLAZZI JOSEPH ODO
权利人:MILES LAB
摘要:The synthesis of 1-( Beta -D-2''-halogeno-2''-deoxyribofuranosyl)- and 1-( Beta -D-2''-mercapto-2''-deoxyribofuranosyl)pyrimidine derivatives from corresponding 2,2''-anhydro-1-( Beta D-arabinofuranosyl)-pyrimidine precursors is improved by utilization of N,N-dimethylformamide as the reaction solvent.

专利号:EP-0513067-A1
优先权日:1990-01-19
标题 :A pratical synthesis of 2'-deoxynucleosides and 2',3'-dideoxy-2',3'-didehydronucleosides

专利号:WO-9110670-A1
优先权日:1990-01-19
标题:A pratical synthesis of 2'-deoxynucleosides and 2',3'-dideoxy-2',3'-didehydronucleosides

专利号:CA-2074184-A1
优先权日:1990-01-19
标 题:Practical synthesis of 2'-deoxynucleosides and 2',3'-dideoxy-2'3'-didehydronucleosides