CAS: 4385-75-5; 4-Pyridin-3-Yl-Benzoic Acid

相似化合物

294648-03-6 127406-55-7 4385-77-7

上下游产品

3-Bromopyridine 4-carboxyphenylboronic acid 4-(pyridin-3-yl)benzaldehyde 4-formylphenylboronic acid, (2R,3R)-2-(3-Cyano-benzyl)-3-(4-pyridin-3-yl-benzoylamino)-butyric acid methyl ester tert-butyl 4-(5-((tert-butyldiphenylsilyloxy)methyl)thiophen-2-yl)-2-(4-(pyridin-3-yl)benzamido)phenylcarbamate 4-(1-oxido-3-pyridinyl)benzoic acid

📜对溴甲苯置于potassium Permanganate,四(三苯基膦)钯,四丁基溴化铵,碘,Caesium Carbonate,Magnesium,Sodium Hydroxide体系中,用 四氢呋喃,水,乙腈 作为反应溶剂,化学反应 54.0H,反应生成 4-吡啶-3-基-苯甲酸
参考文献:Synthesis And Biological Evaluation Of Novel Aromatic-Heterocyclic Biphenyls As Potent Anti-Leukemia Agents
标题:Synthesis And Biological Evaluation Of Novel Aromatic-Heterocyclic Biphenyls As Potent Anti-Leukemia Agents
摘要:As A Continuation To Our Previous Research,Twenty-Eight Aromatic-Heterocyclic Biphenyls Were Designed And Synthesized As Novel Bcr-Abl Inhibitors. The Title Compounds Were Investigated For Their Anti-Proliferative Activities Against Wild K562 Cells And Imatinib-Resistant K562 Cells (K562R). The Results Indicated That Most Of Them Exhibited Potent Bcr-Abl Inhibition And Moderate Antiproliferative Potency Against K562 Cells. Furthermore,Three Compounds 3,7 And 21 Displayed Moderate Antiproliferative Activities Against K562R Cells. Molecular Docking Indicated That 3 Bound More Tightly With Bcr-Abl(T315I) Compared To Bcr-Abl(Wt). The Higher Affinity Was Consistent With Its Relatively Promising K562R Cell Growth Inhibition. These Aromatic-Heterocyclic Biphenyls Could Be Considered As Novel Lead Compound For Optimized As Bcr-Abl(T315I) Inhibitors. They Provide A Good Starting Point For The Further Development Of Novel Anti-Leukemia Agents Capable Of Dealing With Clinical Acquired Resistance Against Imatinib. (C) 2015 Elsevier Masson Sas. All Rights Reserved.
DOI:10.1016/j.Ejmech.2015.07.015