CAS: 42718-15-0; Methyl 2-Amino-2-(4-Bromophenyl)Acetate

上下游产品

CAS号67-56-1 甲醇 | CAS号119397-06-7 2-氨基-2-(4-溴苯基)乙酸 | CAS号709665-73-6 (4-溴苯基)-叔丁氧羰基氨基乙酸甲酯

📜2-(4-溴苯基)-2-氧代乙酸置于氯化亚砜,(S)-2-氯苯甘氨酸体系中,用 水,乙腈 作为反应溶剂,化学反应 41.0H,反应生成 Dl-4-溴苯甘氨酸
参考文献:多组分自由基交叉偶联非天然α-叔氨基酸衍生物的模块化构建
标题:多组分自由基交叉偶联非天然α-叔氨基酸衍生物的模块化构建
摘要:本文报道了一种用于在温和条件下模块化合成 α-叔氨基酸 (Ataa) 的高选择性自由基级联交叉偶联反应.机理研究揭示了原位反应生成的恶唑酮烯醇化物的激发态是一种关键的中间体,它既可以作为自由基前体,也可以作为有效的还原剂.
DOI:10.1002/anie.202210755

专利信息

专利号:US-2024018144-A1
优先权日:2020-10-12
标题:Synthesis of EGFR Modulators
发明人：RECH JASON CHRISTOPHER; NYATI MUKESH K; FANG FAN; ZHANG LEI; HENSCHKE JULIAN PAUL
权利人:UNIV MICHIGAN REGENTS
摘要:Provided herein are processes for synthesizing compounds useful as EGFR modulators. In particular, provided herein are processes for synthesizing Compound A:

专利号:WO-2022077154-A1
优先权日:2020-10-12
标 题:Synthesis of egfr modulators
发明人：RECH JASON CHRISTOPHER; NYATI MUKESH K; FANG FAN; ZHANG LEI; HENSCHKE JULIAN PAUL
权利人:UNIV MICHIGAN REGENTS; RECH JASON CHRISTOPHER; NYATI MUKESH K; FANG FAN; ZHANG LEI; HENSCHKE JULIAN PAUL
摘要:Provided herein are processes for synthesizing compounds useful as EGFR modulators. In particular, provided herein are processes for synthesizing Compound A:

专利号:WO-2022081514-A1
优先权日:2020-10-12
标题:Synthesis of egfr modulators

专利号:US-9795613-B2
优先权日:2014-12-10
标题 :GLP-1 receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM R; BRAHMACHARY ENUGURTHI; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; KNAGGS MICHAEL; GLYNN DANIEL; MILLS MARK
权利人:CELGENE INT II SÀRL
摘要:Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ â€? represents either or both the R and S form of the compound): n nwhere A, B, C, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , W 1 , n, p and q are as defined herein.

专利号:US-9187522-B2
优先权日:2011-12-12
标题 :GLP-1 receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM R; BRAHMACHARY ENUGURTHI; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; KNAGGS MICHAEL
权利人:RECEPTOS INC
摘要:The invention relates to compounds that modulate the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds are act as modulators or potentiators of GLP-1 receptor on their own, or with receptor ligands including GLP-1 peptides GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ â€? represents either or both the R and S form of the compound): n nwhere A, B, C, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , W 1 , n, p and q are as defined herein.

专利号:US-9598430-B2
优先权日:2013-06-11
标 题 :GLP-1 receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM R; BRAHMACHARY ENUGURTHI; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; KNAGGS MICHAEL
权利人:RECEPTOS INC; CELGENE INT II SÀRL
摘要:Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ â€? represents either or both the R and S form of the compound): n nwhere A, B, C, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , W 1 , n, p and q are as defined herein.