CAS: 40546-94-9; 6-Methyl-4-Phenylchroman-2-One

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CAS号106-44-5 对甲酚 | CAS号621-82-9 肉桂酸 | CAS号16299-22-2 6-甲基-4-苯基香豆素 | CAS号140-10-3 肉桂酸 | CAS号3262-89-3 苯硼酸酐 | CAS号102-92-1 β-苯基丙烯酰氯 | CAS号103-26-4 肉桂酸甲酯 | CAS号851789-43-0 2-(3-羟基-1-苯基丙基)... | CAS号124937-51-5 托特罗定 | CAS号209747-04-6 6-methyl-4-phen... | CAS号207679-81-0 (R)-5-羟甲基托特罗定 | CAS号286930-02-7 弗斯特罗定 | CAS号109089-77-2 3-(2-甲氧基-5-甲苯基)... | CAS号124936-74-9 2-[3-(二异丙胺基)-1-... | CAS号124937-73-1 3-(2-甲氧基-5-甲基苯基... | CAS号16299-22-2 6-甲基-4-苯基香豆素 | CAS号854306-71-1 4-methyl-2-[3-[...

4-Methylphenyl Cinnamate置于对甲苯磺酸一水合物体系中,化学反应 4.0H,以83%的收率获得产物6-甲基-4-苯基色满-2-酮
参考文献:Selective Synthesis Of 3,4-Dihydrocoumarins And Chalcones From Substituted Aryl Cinnamic Esters
标题:Selective Synthesis Of 3,4-Dihydrocoumarins And Chalcones From Substituted Aryl Cinnamic Esters
摘要:香豆素广泛存在于植物王国中,并已被用作抗癌剂,抗真菌剂,抗凝血剂和杀虫剂.查尔酮也在植物王国中广泛分布,并且已知具有多种生物活性,包括抗菌,抗真菌,抗癌和抗炎等.由于它们被认为是重要的天然产物,迄今为止已经报道了许多合成方法.我们设计了一种新的选择性方法,通过选择试剂,从芳基肉桂酸制备二氢香豆素和查尔酮.通过使用对甲苯磺酸催化的分子内环化反应,选择性地制备了二氢香豆素衍生物.此外,还通过三氯化钛催化的fries重排反应制备了查尔酮.这种方法可以用于制备各种香豆素和查尔酮化合物.
DOI:10.5012/bkcs.2011.32.1.65

专利信息

专利号:WO-2017137955-A1
优先权日:2016-02-14
标题:Novel (r) and rac 3-(2-(allyloxy)-5-methylphenyl)-n,n-diisopropyl-3- phenylpropan-1-amine and its use for synthesis of (r) and rac-2-(3- (diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol
发明人：THOMBARE PRAVIN SAHADEV
权利人:CELESTIS PHARMACEUTICALS PVT LTD
摘要:The present invention relates to novel chiral 3-(2-(allyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine (5) and racemic 3-(2-(allyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine () and its use in improved and industrially advantageous process for preparation of chiral and racemic form of 2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol. Further, present invention relates to preparation of the same.

专利号:US-2007010691-A1
优先权日:2003-07-02
标 题:Enantioselective synthesis of enantiomerically enriched compounds
发明人：PICCOLO ORESS; ULGHERI FAUSTA; MARCHETTI MAURO
权利人:CONSIGLIO NAZIONALE RICERCHE
摘要:Method of preparing an enantiomerically enriched compound of formula (II) comprising enantioselective hydrogenation of a compound of general formula (I): where W, X and Z have the meanings indicated in the description, to give a compound of general formula (II): where W, Y, T and C* have the meanings indicated in the description, in the presence of a catalyst or its suitable precursor based on Rh, Ru or Ir, having an oxidation state of 0, +1 or +2, and containing at least one enantiomerically enriched chiral ligand.

专利号:US-7119212-B2
优先权日:2004-03-30
标 题 :Process for the preparation of tolterodine and intermediates thereof
发明人：COLOMBO LINO; ROSSI ROBERTO; ALLEGRINI PIETRO; CASTALDI GRAZIANO
权利人:DIPHARMA SPA
摘要:A process for the preparation of 6-methyl-4-(R)-phenyl-chroman-2-one and 6-methyl-4-(S)-phenyl-chroman-2-one, intermediates for the synthesis of tolterodine and its (S) enantiomer, by reaction of 6-methyl-coumarin with phenylboronic acids, esters and derivatives thereof, in the presence of chiral catalysts.

专利号:WO-2005005356-A2
优先权日:2003-07-02
标 题 :Enantioselective synthesis of enantiomerically enriched compounds

专利号:EP-1644311-A2
优先权日:2003-07-02
标题:Enantioselective synthesis of enantiomerically enriched compounds