CAS: 3506-23-8; Puromycin Dihydrochloride
- 英文名称Puromycin Dihydrochloride
- 中文名称嘌呤霉素二盐酸盐水合物
- IUPAC名称(S)-2-amino-N-((2S,3S,4R,5R)-5-(6-(dimethylamino)-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)-3-(4-methoxyphenyl)propanamide hydrochloride
- CAS编号3506-23-8
- MFCD编号:MFCD00012691
- FDA UNII编号:6512V828QH
- 分子式:C22H31Cl2N7O5分子量:544.43
- 产品CID: 1355512
- 同类组份化合物CAS53-79-2 (free base)58-58-2 (2HCl)3506-23-8 (HCl)
- 产品分类原料药 → 抗生素类药物 → 其它抗生素类药
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海关参考信息
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2905122000-异丙醇
2905310000-1,2-乙二醇
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专利信息
专利号:EP-0635577-B1
优先权日:1993-07-23
标 题 :Screen for inhibitors of melanin biosynthesis
发明人：BRINDLE FRANCES HARRIET ELIZAB; FROELIGER EUNICE HARRIET
权利人:BASF AG
摘要:A method for the identification of agents that inhibit melanin biosynthesis involves the incubation of test samples in cultures of a fungus that produces melanin. Observation of altered pigmentation in the culture or culture area containing test sample indicates inhibition of melanin biosynthesis. Preferred cultures for the screen contain a fungus that pigments in the light or the dark such as Cladosporium cucumerinum. Preferred embodiments employ test samples on disks or in wells in solidified cultures and a known melanin synthesis inhibitor as a positive control which is compared to the test sample by simple visual inspection.
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合成参考文献
参考文献:10.1016/j.bbrc.2023.08.050
摘要:Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and Biophysical Research Communications. 2023 Oct;679():116–21. doi: 10.1016/j.bbrc.2023.08.050.
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