专利号:US-6255092-B1 优先权日:1993-09-24 标题:Stereospecific alcohol dehydrogenase isolated from Candida parapsilosis, amino acid and DNA sequences therefor, and method of preparation thereof 发明人:KOJIMA TOMOKO; YAMAMOTO HIROAKI; KAWADA NAOKI; MATSUYAMA AKINOBU 权利人:DAICEL CHEM 摘要:The present invention provides a novel secondary alcohol dehydrogenase useful for the synthesis of optically active alcohol and DNA encoding said enzyme. A microorganism belonging to genus Candida was found to produce a novel secondary alcohol dehydrogenase with a high stereochemical specificity. Using said enzyme, optically active alcohols were prepared, and by cloning of DNA encoding said enzyme, the base sequence of said DNA was determined. By providing a novel secondary alcohol dehydrogenase with a high stereochemical specificity and the gene encoding said enzyme, an efficient production of optically active alcohols became possible.
专利号:WO-9931506-A9 优先权日:1997-12-18 标题:Parallel solution phase synthesis of lactams 发明人:CWI CYNTHIA LYNN; SCOTT WILLIAM LEONARD 权利人:LILLY CO ELI; CWI CYNTHIA LYNN; SCOTT WILLIAM LEONARD 摘要:The present invention provides a parallel solution phase process for making combinatorial arrays of lactam derivatives which are useful for screening for therapeutically useful compounds.
专利号:US-2021379557-A1 优先权日:2018-10-23 标题 :A system and method for promoting chemical reactions 发明人:NAAMAN RON; FONTANESI CLAUDIO; TASSINARI FRANCESCO; MISHRA SURYAKANT; CAPUA EYAL; PALTIEL YOSSEF; YOCHELIS SHIRA; METZGER TZURIEL 权利人:YEDA RES & DEV; YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD 摘要:A system and method for use in synthesis and promoting interactions of chiral molecules. The system can include: a container configured for containing fluid mixture comprising one or more reactant molecules and at least one surface comprising ferromagnetic or paramagnetic material located to be in at least partial contact with reactants in said container. The ferromagnetic of paramagnetic material can be magnetizable with magnetization direction perpendicular to said at least one surface, thereby providing chiral selective synthesis from said one or more reactant molecules. The technique can enable selective interactions of enantiomers of selected handedness of chiral molecules or formation of selected enantiomers from achiral molecule reactants.
专利号:US-2023119463-A1 优先权日:2019-12-27 标题 :1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases 发明人:CHEN YI 权利人:NEWAVE PHARMACEUTICAL INC 摘要:The present invention relates to 1H-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).
专利号:CN-109897810-A 优先权日:2017-12-08 标 题 :Escherichia coli recombinant bacteria for de novo synthesis of vitamin B12 and its construction method and application
专利号:WO-9931506-A1 优先权日:1997-12-18 标题 :Parallel solution phase synthesis of lactams
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