Trans-5,6-Dibromo-7-Oxabicyclo{2.2.1}Heptane-2-Exo,3-Cis-Dicarboxylic Acid Anhydride置于氢氧化钾体系中,化学反应生成3-溴呋喃 参考文献:Process For Preparing 3-Halofuran 标题:Process For Preparing 3-Halofuran
专利信息
专利号:US-4749806-A 优先权日:1984-12-28 标题:Process for the synthesis of isocyanates and of isocyanate derivatives 发明人:TKATCHENKO IGOR; JAOUHARI RABIH; BONNET MICHEL; DAWKINS GORDON; LECOLIER SERGE 权利人:POUDRES & EXPLOSIFS STE NALE 摘要:The present invention relates to a process for the synthesis of isocyanates and of isocyanate derivatives. Isocyanates are obtained by reacting an organic halide with a metal cyanate in an organic medium in the presence of a catalyst consisting of a complex of nickel with at least one organic ligand, in which complex the nickel is in the zero oxidation state. A carbamate or a urea, respectively, are obtained by a subsequent reaction with a hydroxy compound or a primary or secondary amine. Isocyanates and their derivatives are used especially either as refined synthesis agents for the production of pesticides and medications, or as monomers or comonomers for the preparation of many macromolecular compounds.
专利号:US-6172205-B1 优先权日:1997-12-11 标题 :Synthetic process toward total synthesis of eleutherobin and its analogues and uses thereof 发明人:DANISHEFSKY SAMUEL J; CHEN XIAO-TAO; GUTTERIDGE CLARE E; BHATTACHARYA SAMIT K; ZHOU BISHAN 权利人:TRUSTEES OF COLUMBIA IN THE CI 摘要:This invention provides a process for the preparation of a Eleutherobin derivative of the formula: n wherein R 1 is a hydrogen, ester, nitrile or C 2 H 4 —R wherein R 4 is a carbohydrate, an alcohol an amine, an amide, an alkyne, or, R 2 is a linear or branched alkyl moiety, R 3 is an ester, an amide, a carbamate, an acetal compound,an ether or a urethane, R 4 is a hydrogen or CH 2 ,position C 2 and C 3 is cis or trans,position C 8 is α or β and a compound is produced having the structures: n Additionally, this experiment provides a method for inhibiting growth of cancerous cells comprising contracting an amount of Eleutherobin derivative effective to inhibit the growth of said cells. Further provided is a method for treating cancer in a subject which comprises administering to the subject a therapeutically effective amount of the Eleutherobin derivative.
专利号:US-9034439-B2 优先权日:2008-03-04 标题:Synthesis and applications of soluble pentacene precursors and related compounds 发明人:CHOW TAHSIN J; WU CHUNG-CHIH; CHUANG TA-HSIEN; HSIEH HSING-HUNG; HUANG HSIN-HUI 权利人:CHOW TAHSIN J; WU CHUNG-CHIH; CHUANG TA-HSIEN; HSIEH HSING-HUNG; HUANG HSIN-HUI; ACADEMIA SINICA 摘要:The present disclosure relates to methods and systems for synthesis of bridged-hydropentacene, hydroanthracene and hydrotetracene from the precursor compounds pentacene derivatives, tetracene derivatives, and anthracene derivatives. The invention further relates to methods and systems for forming thin films for use in electrically conductive assemblies, such as semiconductors or photovoltaic devices.
专利号:US-11512075-B2 优先权日:2017-06-14 标 题:Synthesis of 20-nor-salvinorin A 发明人:SHENVI RYAN; ROACH JEREMY; SASANO YUSUKE; BOHN LAURA; SCHMID CULLEN 权利人:SCRIPPS RESEARCH INST 摘要:The invention provides 20-nor-salvinorin A, an analog of the kappa-opioid agonist salvinorin A. The 20-nor-salvinorin A is an active kappa-opioid modulator and can be used for treatment of medical conditions wherein modulation of the kappa-opioid receptor is medically indicated, such as pain, pruritis, depression, or inflammation, or conditions implicating perception and consciousness. 20-nor-salvinorin A can be less additive when used in treatment compared to a mu-opioid receptor agonist, and 20-nor-salvinorin A is more stable in vivo than is parent compound salvinorin A. The invention further provides synthetic intermediates and procedures for preparation of 20-nor-salvinorin A.
专利号:US-2008280855-A1 优先权日:2005-06-22 标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles 发明人:CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO 权利人:NYCOMED GMBH 摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.
专利号:US-4259240-A 优先权日:1979-09-28 标 题:Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom 发明人:WIESNER KAREL; TSAI THOMAS Y R 权利人:ADVANCE BIOFACTURES CORP 摘要:The invention relates to furyl intermediates and the preparation thereof, said intermediates being particularly useful in the preparation of synthetic cardenolides and their isomers. The process provides for the reaction of an unsaturated steroidal 17 ketone with a β-furyl compound to produce an allylic alcohol which is subjected to acetylation and allylic rearrangement. The resulting material is then hydrogenated to produce the furyl intermediate. Cardenolides are formed therefrom by oxidation of the furyl intermediates.
[参考文献]: Adam Mccluskey, Et Al. Cantharidin Analogues: Synthesis And Evaluation Of Growth Inhibition In A Panel Of Selected Tumour Cell Lines. Bioorg Chem. 2003 Feb;31(1):68-79.
合成参考文献
摘要:Hou, X.-L.; Peng, X.-S.; Yeung, K.-S.; Wong, H. N. C., Science of Synthesis Knowledge Updates, (2011) 2, 349. 摘要:Ihmels, H., Science of Synthesis Knowledge Updates, (2011) 1, 85. 摘要:Rudzinski, D. M.; Leadbeater, N. E., Science of Synthesis Knowledge Updates, (2012) 1, 403. 摘要:Kawęcki, R., Science of Synthesis Knowledge Updates, (2018) 4, 366. 摘要:Wang, K.; Wang, J., Science of Synthesis, (2022) , 30.