CAS: 20357-20-4; 5-Bromo-2-Nitrobenzaldehyde

该化合物是一种黄到橙色晶状的固体,并因其再活动而闻名,因为存在藻类和硝基功能组,它们都可参与各种化学反应,包括核脑生物学替代和减少.它经常用于有机合成,特别是用于制作更复杂的分子和作为生产药品和农用化学品的一种中间体.此外,5-Bromo-2-nitrobenzalthyde 5的物性特性,例如有机溶剂中的中溶性和在标准实验室条件下的稳定性,尽管应注意其潜在的毒性和环境影响.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

m-bromobenzoic aldehyde 2,4-dibromonitrobenzene N,N-dimethyl-formamide [(E)-2-(5-bromo-2-nitro-phenyl)-vinyl]-dimethyl-amine trans-cinnamic acid5-bromo-2-nitro-trans-cinnamic acid 5-bromo-2-nitro-mandelonitrile 5-bromo-2-nitro-cinnamic acid H,1'H-[2,2']biindolylidene-3,3'-dione5,5'-dibromo-1H,1'H-[2,2']biindolylidene-3,3'-dione

合成工艺路线路线简述

  • 3132-99-8 = 20357-20-4 + 882772-99-8
    反应条件:1.1 Reagents: Sulfuric Acid,Potassium Nitrate Solvents: Water; < 30 °C; 16 H,23 °C
    标题:New Octahydropyrido[3,4-B]Acridine Scaffolds For Combinatorial Chemistry
    作者:Diedrich,Claas Lueder; Et Al
    参考文献:Synthesis 日期:2008 卷标:(14) 页码:2199-2210]

    552-89-6 = 20357-20-4 + 56990-05-7 + 1559060-83-1 + 882772-99-8 + 5551-12-2 + 20357-21-5 + 213382-42-4
    反应条件:1.1 Reagents: N-Bromosuccinimide,Sulfuric Acid; 3 H,Rt1.2 Reagents: Water; Cooled
    标题:Reexamination Of The Bromination Of 2-Nitrobenzaldehyde With Nbs Or Nabr-Naio4 In Sulfuric Acid
    作者:Cummings,Matthew M.; Et Al
    参考文献:Synthetic Communications 日期:2014 卷标:44(7) 页码:954-958
📜[(E)-2-(5-Bromo-2-Nitro-Phenyl)-Vinyl]-Dimethyl-Amine置于sodium Periodate体系中,用 四氢呋喃,水 用作溶剂,化学反应 1.0H,以71%的收率获得5-溴-2-硝基苯甲醛
参考文献:6-Membered Aryl And Heteroaryl Derivatives For Treating Viruses
标题:6-Membered Aryl And Heteroaryl Derivatives For Treating Viruses
摘要:公开了用于治疗黄病毒科病毒感染的化合物,组合物和方法.

海关参考信息

专利信息


专利号:US-9243002-B2
优先权日:2013-02-07
标题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C
发明人：DAI XING; LIU HONG; PALANI ANANDAN; HE SHUWEN; BROCKUNIER LINDA L; NARGUND RAVI; MARCANTONIO KAREN; ZORN NICOLAS; XIAO DONG; PENG XUANJIA; LI PENG; GUO TAO
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9205087-B1
优先权日:2014-02-19
标题:6-Piperazinyl-3,4-dihydroquinazolin-2(1H)-ones
发明人：ULLAH NISAR
权利人:UNIV KING FAHD PET & MINERALS; KING ABDULAZIZ CITY SCI & TECH
摘要:A series of new 6-piperazinyl-3,4-dihydroquinazolin-2(1H)-ones have been synthesized. The compounds are structurally related to adoprazine, a potential atypical antipsychotics bearing potent D 2 receptor antagonist and 5-HT 1A receptor agonist properties. Buchwald-Hartwig coupling of suitably modified aryl bromides with tert-butyl piperazine-1-carboxylate afforded the advanced intermediate piperazinyl-3,4-dihydroquinazolin-2(1H)-one. The reductive amination of the latter with appropriately designed biarylaldehydes accomplished the synthesis of these compounds.

专利号:CN-101638371-A
优先权日:2009-08-28
标 题 :Synthesis of 5-(N-secondary amino)-2-nitrobenzaldehyde

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主要参考文献

参考标题:Synthesis Of 2-Substituted Quinolines From 2-Aminostyryl Ketones Using Iodide As A Catalyst
作者:So Young Lee,Jiye Jeon,Cheol-Hong Cheon |发布日期:2018.5.4
摘要:A New Protocol For The Synthesis Of 2-Substituted Quinolines From 2-Aminostyryl Ketones Has Been Developed Using Iodide As A Nucleophilic Catalyst. Conjugate Addition Of Iodide To 2-Aminostyryl Ketones Yielded The Corresponding β-Iodoketones, Which Could Have A Conformation Where The Amino And Carbonyl Groups Are Proximal Through Free Rotation About The Cα-Cβ Single Bond. Subsequent Condensation Between

合成参考文献


摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 345.
摘要:Schiltz, P.; Gosmini, C., Science of Synthesis: Special Topics, (2021) 1, 86.
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